The effects of levobupivacaine infiltration on post-tonsillectomy pain relief in adults: a single-blinded, randomized, and controlled clinical study

Abstract

The aim of this prospective single-blinded and controlled study is to evaluate the efficacy of levobupivacaine infiltration on post-tonsillectomy pain relief in adults. The study was conducted with 40 adult patients who underwent tonsillectomy. These patients were randomized in either study group (SG) who received levobupivacaine infiltration to peritonsillary fossae prior to surgery or control group (CG) with no medication. After surgery, all the patients were queried for pain scores by visual analog scale. In addition, the volume of intraoperative bleeding, the duration of operation, the severity of postoperative complications, and the amount of analgesic requirement were the other outcome measures of this study. There were significant differences between groups regarding pain scores for the first 24 h in favor of SG. The analgesic requirement was also significantly lower in SG (p = 0.009). Although there was a sustained decrement at pain score during first 24 h for SG, however, the change from baseline score (immediate score) for each time interval revealed no significance compared to CG. In addition, the duration of operation and the volume of intraoperative bleeding were similar (p = 0.64 and p = 0.165). In conclusion, preincisional infiltration of levobupivacaine is a safe and reliable method for post-tonsillectomy pain reduction in adults. However, more in-depth, double-blinded and placebo controlled studies are required to elucidate its long term benefits.

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Efficacy of Sucralfate in Alleviating Pain And Morbidity in Post-Tonsillectomy Patients- A Randomized Control Trial

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A Randomized Single‐Blinded Trial of Posttonsillectomy Liposomal Bupivacaine among Adult Patients

“…Recent studies, such as those by Erdogan et al in 2014 and Kaspoglu et al in 2013, demonstrated statistically significant reductions in pain scores among adult tonsillectomy patients treated with bupivacaine in comparison with placebo. 16,17 Alternatively, in 1993 Schoem et al executed a prospective randomized double-blind study with plain bupivacaine after adult tonsillectomy, looking at pain intensity scores, medication usage, and oral intake. 18 Their study showed no significant difference between the group receiving the bupivacaine injection and the group receiving a saline injection, and this has been seen in others' studies as well.…”