Efficacy of Sucralfate in Alleviating Pain And Morbidity in Post-Tonsillectomy Patients- A Randomized Control Trial

Alexander, Arun

doi:10.19080/gjo.2018.17.555957

Cited by 1 publication

(3 citation statements)

References 8 publications

(21 reference statements)

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“…Sucralfate has been shown to have analgesic properties in various conditions. The primary action of sucralfate is idiopathic; meanwhile, several studies showed the effect of sucralfate 46,47 . Aside from the anti‐peptic effect, sucralfate increases angiogenesis and the bioavailability of growth factors, including fibroblast growth factor (FGF), epidermal growth factor (EGF), and tissue growth factor (TGF); thus, it enhances epithelialization and mucosal protection resulting in the reduction of pain and improving wound healing 36,48,49 .…”

Section: Discussionmentioning

confidence: 99%

“…The primary action of sucralfate is idiopathic; meanwhile, several studies showed the effect of sucralfate. 46 , 47 Aside from the anti‐peptic effect, sucralfate increases angiogenesis and the bioavailability of growth factors, including fibroblast growth factor (FGF), epidermal growth factor (EGF), and tissue growth factor (TGF); thus, it enhances epithelialization and mucosal protection resulting in the reduction of pain and improving wound healing. 36 , 48 , 49 In conjunction with the pharmacodynamics of sucralfate, this study demonstrated linear results in which sucralfate is beneficial and significantly improves pain and wound healing.…”

Section: Discussionmentioning

confidence: 99%

“…The primary action of sucralfate is idiopathic; meanwhile, several studies showed the effect of sucralfate. 46,47 Aside from the anti-peptic effect, sucralfate…”

Section: Funding Informationmentioning

confidence: 99%

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The efficacy of topical sucralfate in improving pain and wound healing after haemorrhoidectomy procedure: A systematic review, meta‐analysis, and meta‐regression of randomised clinical trials

Rudiman

Hanafi

Evan

et al. 2022

International Wound Journal

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Pain and wound after haemorrhoidectomy constantly bothered the patient's convenience. Recurrently, topical sucralfate is used to treat excoriations and burns. It is considered to enhance epidermal growth and tissue granulation, thus, alleviating patients' problems. This study evaluated topical sucralfate's feasibility, safety, and superiority after haemorrhoidectomy. We searched randomised controlled trial (RCT) studies in PubMed, Google Scholar, Europe PMC, and ClinicalTrials.gov until March 29th, 2022. We investigated the influence of topical sucralfate on pain score postoperatively (24 hours, 7 days, and 14 days), pethidine usage, diclofenac usage, and wound healing rate compared to placebo. This study was conducted following the PRISMA guidelines. This study sorted the final six studies with 439 patients underwent haemorrhoidectomy. Topical sucralfate demonstrated significant outcomes on VAS 24 hours post-operative [Std. Mean Difference À1.00 (95% CI À1.70, À0.31), P = .005], VAS 7 days post-operative [Std. Mean Difference À2.29 (95% CI À3.34, À1.25), P < .0001], VAS 14 days post-operative [Std. Mean Difference À1.88 (95% CI À2.74, À1.01), P < .0001], pethidine usage within 24 hours post-operative [Std. Mean Difference À0.62 (95% CI À0.96, À0.27), P = .0004], diclofenac usage 7 days post-operative [Std. Mean Difference À1.76 (95% CI À2.61, À0.92), P < .0001], diclofenac usage 14 days post-operative [Std. Mean Difference À1.64 (95% CI À2.38, À0.91), P < .0001], and wound healing rate at 28-day post-operative [RR 1.45 (95% CI 1.25-1.68), P < .00001]. Topical sucralfate alleviated pain, improved wound healing, and minimised the usage of pethidine and diclofenac compared to placebo.

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Section: Discussionmentioning

confidence: 99%