The effects of irradiation on controlled drug delivery/controlled drug release systems

Ražem, Dušan; Katušin-Ražem, Branka

doi:10.1016/j.radphyschem.2007.06.006

Cited by 50 publications

(29 citation statements)

References 181 publications

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“…Sterilization of all medical implants prior to implantation is important, 1 and sterilization procedures can have a significant effect on the polymers’ properties, including the release rate of an implantable drug delivery system. 2, 3 …”

Section: Introductionmentioning

confidence: 99%

Thermomechanical properties, antibiotic release, and bioactivity of a sterilized cyclodextrin drug delivery system

et al. 2014

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Various local drug delivery devices and coatings are being developed as slow, sustained release mechanism for drugs, yet the polymers are typically not evaluated after commercial sterilization techniques. We examine the effect that commercial sterilization techniques have on the physical, mechanical, and drug delivery properties of polyurethane polymers. Specifically we tested cyclodextrin-hexamethyl diisocyanate crosslinked polymers before and after autoclave, ethylene oxide, and gamma radiation sterilization processes. We found that there is no significant change in the properties of polymers sterilized by ethylene oxide and gamma radiation compared to non-sterilized polymers. Polymers sterilized by autoclave showed increased tensile strength (p<0.0001) compared to non-sterilized polymers . In the release of drugs, which were loaded after the autoclave sterilization process, we observed a prolonged release (p<0.05) and a prolonged therapeutic effect (p<0.05) but less drug loading (p<0.0001) compared to non-sterilized polymers. The change in the release profile and tensile strength in polymers sterilized by autoclave was interpreted as being caused by additional crosslinking from residual, unreacted, or partially-reacted crosslinker contained within the polymer. Autoclaving therefore represents additional thermo-processing to modify rate and dose from polyurethanes and other materials.

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Section: Introductionmentioning

confidence: 99%

Thermomechanical properties, antibiotic release, and bioactivity of a sterilized cyclodextrin drug delivery system

et al. 2014

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“…For instance, conventional 25-kGy γ-sterilization procedure can be applied to ALP enzyme-grafted biomaterials without noticeable loss of ALP activity [87]. Several other literature reports suggested that γ-irradiation is less detrimental for growth factor stability and, therefore, this method has already been applied to BMP-2 using an irradiation dose of 25 kGy [90][91][92][93]. Indeed, this dose is recommended by the European Medicines Agency [94].…”

Section: Sterilization By -Irradiationmentioning

confidence: 99%

Matrix‐Bound Presentation of Bone Morphogenetic Protein 2 by Multilayer Films: Fundamental Studies and Applicationsto Orthopedics

Gilde

Guillot

Fourel

et al. 2015

Layer‐by‐Layer Films for Biomedical Applications

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“…There have been several recent reviews concerned with the effect of sterilisation doses of radiation on polymeric carriers for drugs (Sintzel et al ., 1997;Bhattacharya, 2000;Clough, 2001;Edlund and Albertsson, 2002;Jain et al ., 2005;Razem and Katusin-Razem, 2008). The review by Razem and Katusin-Razem is a particularly detailed review of drug-loaded carrier systems studied since 1990.…”

Section: Sterilisation Of Drug-delivery Systems Using Radiationmentioning

confidence: 99%

Sterilisation of healthcare products by ionising radiation: sterilisation of drug-device products and tissue allografts

Parsons

2012

Sterilisation of Biomaterials and Medical Devices

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The effects of irradiation on controlled drug delivery/controlled drug release systems

Cited by 50 publications

References 181 publications

Thermomechanical properties, antibiotic release, and bioactivity of a sterilized cyclodextrin drug delivery system

Thermomechanical properties, antibiotic release, and bioactivity of a sterilized cyclodextrin drug delivery system

Matrix‐Bound Presentation of Bone Morphogenetic Protein 2 by Multilayer Films: Fundamental Studies and Applicationsto Orthopedics

Sterilisation of healthcare products by ionising radiation: sterilisation of drug-device products and tissue allografts

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