The effects of ionizing radiation on biomembrane structure and function

Edwards, James; Chapman, D.; Cramp, W.A.; Yatvin, Milton B.

doi:10.1016/0079-6107(84)90004-x

Cited by 122 publications

(39 citation statements)

References 111 publications

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“…The reasoning which supports the hypothesis that the nuclear membrane in mammalian cells and the plasma membrane in bacteria are potential targets because of their close proximity to nuclear material can also be found in these references (6)(7)(8)(9)(10).…”

supporting

confidence: 50%

“…The effccts of ionising radiation on these membrane characteristics have been widely reported over the past four dccadcs and we have reviewed this area on two previous occasions (6,7). I n particular.…”

mentioning

confidence: 99%

“…The role and structure of cellular membranes have been described in some detail in the extensive review by Edwards et al (6), which is particularly relevant to radiation studies. As a brief reminder of the involvemcnt of cellular membranes, we list the following cellular functions.…”

mentioning

confidence: 99%

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Recent Developments in the Radiobiology of Cellular Membranes

Cramp¹,

Yatvin²,

Harms‐Ringdahl³

1994

Acta Oncologica

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supporting

confidence: 50%

mentioning

confidence: 99%

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Recent Developments in the Radiobiology of Cellular Membranes

Cramp¹,

Yatvin²,

Harms‐Ringdahl³

1994

Acta Oncologica

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“…Melatonin (N-acetyl-5-metoxytriptamine) is a known agent preventing oxidative damage of the toxins and radiotherapy with its free radical scavenging capacity (Martinez-Cayuela, 1955;Edwards et al, 1984;Verma and Sonwalker, 1991). In in vitro experiments it was shown that melatonine was 5 and 14-fold more potent than glutathione and mannitol, respectively, in scavenging hydroxyl radicals.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Melatonine Against Radiation Induced Nephrotoxicity in Rats

Küçüktülü¹,

Yavuz²,

Çobanoğlu³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Protective Effect of Melatonine Against Radiation Induced Nephrotoxicity in Rats 13, 4101-4105 IntroductionKidneys are frequently included into the therapy area during radiotherapy applications. The extent of radiation damage depends on both dose and volume of radiation (Perez et al., 2008). Renal tolerance dose is 20 Gy in bilateral irradiation, while in unilateral exposure renal dysfunction starts in 15 Gy and renal function is completely lost in doses of 25-30 Gy. Concomitant use of cisplatin some chemicals such as BCNU and actinomycin further lowers the tolerance dose. When renal tolerance dose is exceeded after a latent period of 6 mounts acute nephritis develops, after 18 mounts on chronic nephritis and hiperreninemic hypertension is observed. In histopathologic examination interstial edema secondary to increased capillary permeability is evident in acute phase, (Zaki et al., 2003).Rapid multiplication of the tumoral cell leaves hypoxia and necrotic areas at the center of the tumors. Since radiation is ineffective at these regions, higher radiation doses are usually required at the tumor center to control tumoral multiplication. The normal tissue surrounding the tumor is rich in blood vessels and well oxygenated, AbstractPurpose: The degree of radiation injury to kidneys which are located within the limits of radiotherapy area is determined by the volume and the dose of radiation to which the organ is exposed. When the tolerance dose of the kidney is exceeded after a latent period of 6 months acute nephritis develops and after 18 months chronic nephritis ensues. Melatonin is known to prevent the oxidative injury of toxins and radiotherapy with its free radical scavenging capacity. Methods and materials: In this study 8 weeks old 24 Sprague -Dawley rats were allocated into 4 groups: Control group; Radiotherapy group (20 Gy bilaterally in 5 fractions); Melatonin group (10 mg/kg intraperitoneally), and Melatonin+radiotherapy group (20 Gy Radiotherapy in 5 fractions+ melatonin 10 mg/kg intraperitoneally). After a follow-up period of 6 months BUN was determined in all groups. After rats were euthanized the kidneys were removed for histopathological examination under both light and electron microscopes. Results: After 6 months follow-up, both at light and electron microscopy levels, the radiotherapy group (p<0.05). Conclusion: It was shown in this experimental model that melatonin has protective effects against radiation injury to kidneys.

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“…The range of antioxidant defenses available within the cell and in the extracellular fluid should be adequate to protect against oxidative damage [1] . DNA, lipids and proteins are attacked by free radicals induced by ionizing radiation [3][4][5] . Oxidative stress clearly plays a crucial role in the development and pathogenesis of chronic renal failure [6] .…”

Section: Introductionmentioning

confidence: 99%

Effects of Two Different Dose Levels of Irradiation on Thioredoxin Reductase in the Kidney of Guinea Pigs

Güney¹,

Turkcu²,

Kılıç³

et al. 2006

American J. of Immunology

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Abstract:It is aimed to examine the state of the oxidant-antioxidant system in the liver of guinea pig caused by ionizing radiation at two different dose levels in the early period. The research was carried out on guinea pigs irradiated with the doses of 8 Gy (group 2) or 15 Gy (group 3) (single dose/whole body) in comparison with control group (group 1). The levels of thioredoxin reductase (TR) in the kidney was measured. The results obtained by non-irradiated and irradiated (8 Gy and 15 Gy) kidneys on guinea pigs indicated that; in 8-15 Gy irradiated animal kidneys TR activity elevated significantly (p<0.001) when compared to the controls, but there was no difference between 8 Gy and 15 Gy irradiated animal groups. The data have shown that gamma-irradiation results in significant increase in TR activity at two different dose levels.

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The effects of ionizing radiation on biomembrane structure and function

Cited by 122 publications

References 111 publications

Recent Developments in the Radiobiology of Cellular Membranes

Recent Developments in the Radiobiology of Cellular Membranes

Protective Effect of Melatonine Against Radiation Induced Nephrotoxicity in Rats

Effects of Two Different Dose Levels of Irradiation on Thioredoxin Reductase in the Kidney of Guinea Pigs

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