The effects of intravenous romifidine on intraocular pressure in clinically normal horses and horses with incidental ophthalmic findings

Abstract

Administration of romifidine significantly decreased the IOP from baseline at all time points measured. The greatest decline in IOP was noted at 15 min postsedation. Results are consistent with other studies noting a decline in IOP with administration of α-2 agonists.

Intraocular pressure reference intervals in eyes of clinically normal miniature donkeys (Equus africanus asinus)

“…Several studies have documented a decline in IOP following administration of α‐2 agonists. Intravenous administration of detomidine caused a decrease in IOP in clinically normal horses and romifidine significantly decreased IOP from baseline in clinically normal horses at two different doses, both given intravenously . Similarly, intravenous administration of xylazine in another study resulted in a significant decrease in IOP as well .…”

Effect of intravenous administration of romifidine on intraocular pressure in clinically normal horses

“…Nevertheless, information on effects of IV administration of romifidine on IOP is limited. A recent study in normal horses conducted using applanation tonometry reported that administration of IV romifidine at a 75 μg/kg dose causes a significant decrease in IOP . In that study, The IOP readings were only recorded at 5, 15, 30, 45 and, 60 min postsedation in both eyes.…”

“…A recent study in normal horses conducted using applanation tonometry reported that administration of IV romifidine at a 75 lg/kg dose causes a significant decrease in IOP. 18 In that study, The IOP readings were only recorded at 5, 15, 30, 45 and, 60 min postsedation in both eyes. As the sedative effects of romifidine at a dose of 40-80 lg/kg last for approximately 80 min, 11 this study did not determine whether this effect on IOP persists over the period of 80 min.…”

The investigation of xylazine, detomidine, isoflurane and sevoflurane anaesthetic combinations on clinical, laboratory and cardiovascular parameters and on intraocular pressure in horses

“…The reference range for horses using tonometry is reported as 15-37 mmHg (Komáromy et al, 2006;Monk et al, 2017). Several factors such as the time of day, sedation, anesthetic agents and head position influence the IOP (Hall et al, 2000;Stine et al, 2014;Arıcan et al, 2015;Monk et al, 2017). In the present study, there were no statistical differences seen in IOP values at the 0th, 5th, 15th, 30th and 60th minutes of anaesthesia between and within groups.…”