The effects of interstitial tissue pressure on the measured shear modulus in vivo

Weaver, John B.; Perríñez, Phillip R.; Bergeron, Jeffrey A.; Kennedy, Francis E.; Lollis, S. Scott; Doyley, Marvin M.; Hoopes, P. J.; Paulsen, Keith D.

doi:10.1117/12.713781

Cited by 11 publications

(10 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Qualitative inspection of Figs. 7 and 8 indicates that regions of higher predicted shear modulus correspond with regions of high nodal pressure and pressure gradient, in agreement with the observations reported by Weaver et al [21]. In addition, regions of high pressure gradient corresponded to areas where significant differences in volumetric strain occurred between the two models.…”

Section: Discussionsupporting

confidence: 90%

“…Recent studies by Franceschini et al [19], and Cheng and Bilston [20] have shown that incorporation of poroelastic constitutive relations into combined tissue models is better at capturing the total deformation behavior of brain. Further, Weaver et al [21] have investigated the relationship between reconstructed elastic parameters and brain interstitial fluid pressure (IFP) in porcine subjects. The average shear modulus over the brain was observed to decrease with time after anesthesia, following a general trend of decreasing arterial blood pressure.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Modeling of Soft Poroelastic Tissue in Time-Harmonic MR Elastography

Perríñez

Kennedy

Houten

et al. 2009

IEEE Trans. Biomed. Eng.

View full text Add to dashboard Cite

Elastography is an emerging imaging technique that focuses on assessing the resistance to deformation of soft biological tissues in vivo. Magnetic resonance elastography (MRE) uses measured displacement fields resulting from low-amplitude, low-frequency (10 Hz-1 kHz) timeharmonic vibration to recover images of the elastic property distribution of tissues including breast, liver, muscle, prostate, and brain. While many soft tissues display complex time-dependent behavior not described by linear elasticity, the models most commonly employed in MRE parameter reconstructions are based on elastic assumptions. Further, elasticity models fail to include the interstitial fluid phase present in vivo. Alternative continuum models, such as consolidation theory, are able to represent tissue and other materials comprising two distinct phases, generally consisting of a porous elastic solid and penetrating fluid. MRE reconstructions of simulated elastic and poroelastic phantoms were performed to investigate the limitations of current-elasticity-based methods in producing accurate elastic parameter estimates in poroelastic media. The results indicate that linearly elastic reconstructions of fluid-saturated porous media at amplitudes and frequencies relevant to steady-state MRE can yield misleading effective property distributions resulting from the complex interaction between their solid and fluid phases.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Modeling of Soft Poroelastic Tissue in Time-Harmonic MR Elastography

Perríñez

Kennedy

Houten

et al. 2009

IEEE Trans. Biomed. Eng.

View full text Add to dashboard Cite

show abstract

“…The stress relaxation testing and the KVFD modeling approaches provide the frequency-dependent storage and loss moduli, from which both elastic and viscous behavior can be extracted. For in-vitro conditions, the elastic contrast between cancer and normal appears to be 2.6:1 at 150 Hz, although the in-vivo contrast could be higher as a result of the additional effects of elevated interstitial pressure (Weaver et al 2007).…”

Section: Discussionmentioning

confidence: 93%

Quantitative Characterization of Viscoelastic Properties of Human Prostate Correlated with Histology

Zhang

Nigwekar

Castaneda

et al. 2008

Ultrasound in Medicine & Biology

182

135

View full text Add to dashboard Cite

“…Namely, although not for the spinal cord specifically, data from Weavee et al have suggested that perfusion pressure may have a dramatic effect on the shear modulus of biological tissues generally - Figure 6. Their results suggest that shear modulus may vary by as much as 0.1 -0.3 kPa/mmHg [86]. And, given that spinal cord perfusion pressure is normally in the region of 50 -140 mmHg [87,88], this means that there may be large discrepancies in modulus values between perfused (live) and non-perfused (dead) tissue.…”

Section: Current Understanding Of the Mechanical Properties Of Spinalmentioning

confidence: 99%

Biomechanical Properties of the Spinal Cord: Implications for Tissue Engineering and Clinical Translation

2016

View full text Add to dashboard Cite

Spinal cord injury is a severely debilitating condition which can leave individuals paralyzed and suffering from autonomic dysfunction. Regenerative medicine may offer a promising solution to this problem. Previous research has focused primarily on exploring the cellular and biological aspects of the spinal cord, yet relatively little remains known about the biomechanical properties of spinal cord tissue. Given that a number of regenerative strategies aim to deliver cells and materials in the form of tissue-engineered therapies, understanding the biomechanical properties of host spinal cord tissue is important. We review the relevant biomechanical properties of spinal cord tissue and provide the baseline knowledge required to apply these important physical concepts to spinal cord tissue engineering.

show abstract

The effects of interstitial tissue pressure on the measured shear modulus in vivo

Cited by 11 publications

References 24 publications

Modeling of Soft Poroelastic Tissue in Time-Harmonic MR Elastography

Modeling of Soft Poroelastic Tissue in Time-Harmonic MR Elastography

Quantitative Characterization of Viscoelastic Properties of Human Prostate Correlated with Histology

Biomechanical Properties of the Spinal Cord: Implications for Tissue Engineering and Clinical Translation

Contact Info

Product

Resources

About