The Effects of<i>Rhodiola rosea</i>L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms

Cropley, Mark; Banks, Adrian P.; Boyle, Julia

doi:10.1002/ptr.5486

Cited by 66 publications

(45 citation statements)

References 22 publications

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“…Rhodiola ( Rhodiola rosea ) is a perennial plant used in traditional medicine in Asia and in Eastern Europe to improve physical endurance and mental performance. Results from studies of the root extract involving patients with anxiety (Cropley, Banks, & Boyle, ) and depression (Darbinyan et al, ) show that it can reduce symptoms when compared with placebo. In adults with stress‐related fatigue, an R .…”

Section: Resultsmentioning

confidence: 99%

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Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho‐oncologic relevance

Yeung

Hernandez

Mao

et al. 2018

Phytotherapy Research

158

100

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Anxiety and depression are prevalent among cancer patients, with significant negative impact. Many patients prefer herbs for symptom relief to conventional medications which have limited efficacy/side effects. We identified single-herb medicines that may warrant further study in cancer patients. Our search included PubMed, Allied and Complementary Medicine, Embase, and Cochrane databases, selecting only single-herb randomized controlled trials between 1996 and 2016 in any population for data extraction, excluding herbs with known potential for interactions with cancer treatments. One hundred articles involving 38 botanicals met our criteria. Among herbs most studied (≥6 randomized controlled trials each), lavender, passionflower, and saffron produced benefits comparable to standard anxiolytics and antidepressants. Black cohosh, chamomile, and chasteberry are also promising. Anxiety or depressive symptoms were measured in all studies, but not always as primary endpoints. Overall, 45% of studies reported positive findings with fewer adverse effects compared with conventional medications. Based on available data, black cohosh, chamomile, chasteberry, lavender, passionflower, and saffron appear useful in mitigating anxiety or depression with favorable risk-benefit profiles compared to standard treatments. These may benefit cancer patients by minimizing medication load and accompanying side effects. However, well-designed larger clinical trials are needed before these herbs can be recommended and to further assess their psycho-oncologic relevance.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho‐oncologic relevance

Yeung

Hernandez

Mao

et al. 2018

Phytotherapy Research

158

100

View full text Add to dashboard Cite

show abstract

“…Additionally, it has been widely used as an astringent in traditional herbal medicine. It has also been reported that Rhodiola infusion possesses a beneficial effects on mouth pain and kidney stones, swellings, back pain, as well as mood disorders (Panossian et al, 2010;;Cropley et al, 2015). In addition to these beneficial effects, it has been reported that Rhodiola infusion has significant effects on hair growth (Panossian et al, 2010;Zhu et al, 2014).…”

Section: Rhodiola Rosea L In Traditional Medicinementioning

confidence: 99%

Rhodiola rosea L. and Alzheimer's Disease: From Farm to Pharmacy

Nabavi

Braidy

Orhan

et al. 2016

Phytotherapy Research

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Rhodiola rosea L. (roseroot) is a common member of the family Crassulaceae, known as one of the most important popular medicinal plants in the northern region of Europe. The roots of R. rosea possess a wide range of pharmacological activities such as antioxidant, antiinflammatory, anticancer, cardioprotective, and neuroprotective effects that are because of the presence of different phytochemicals such as phenols and flavonoids. In addition, the presence of salidroside, rosavins, and p-tyrosol are responsible for its beneficial effects for the treatment of on depression, fatigue, and cognitive dysfunction. A plethora of studies report that R. rosea has potent neuroprotective effects through the suppression of oxidative stress, neuroinflammation, and excitotoxicity in brain tissues and antagonism of oncogenic p21-activated kinase. However, to our knowledge, no review articles have been published addressing the neuroprotective effects of R. rosea. Therefore, the present article aims at critically reviewing the available literature on the beneficial effects of R. rosea on as a therapeutic strategy for the treatment of Alzheimer's disease and other neurodegenerative diseases where oxidative stress plays a major role in disease development and progression. We also discuss the cultivation, phytochemistry, clinical impacts, and adverse effects of R. rosea to provide a broader insight on the therapeutic potential for this plant.

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“…rosea is system-stimulating serotonin-5 and the nervous treatment system with the process of oxidative deamination and peripheral tissue. The level of MAO A inhibitors has shown to be active and often associated with pharmacological treatment [61].…”

Section: Roserootmentioning

confidence: 99%

Medicinal Herbs and Phytochemicals Used in the Treatment of Depression: A Review

Mehdi

et al. 2019

Asian J Pharm Clin Res

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Depression is a condition of no mood and loss of interest in any activity that can diminish a person’s thinking, conduct, tendencies, emotional state, and a sense of well-being. Although there is a conventional class of medication which have been beneficial in the treatment of depression, current studies have reported having side effects which can be minimized by the intervention of herbs and phytochemicals. Most of the studies have proven the various mechanisms and have started to research a very ground-breaking method by glancing the ancient treatmen. Where this new approach of using the herbs and phytochemicals has shown better results alone and in combination with conventional drugs which has shown lesser adverse effects. The practice of phytomedicine is an additional option for the treatment of depression. In the various segments of treating the depression, the mainstream can be a breakthrough including phytoconstituents. In this aspect, there are many contributions for the treatment of the depression acting to the neuronal level signaling and the phytoconstituents also have shown some basic mechanisms in the treatment of depression as that of the conventional medications following some primary hypothesis and signaling pathways and life interactions that effects the brain in either way to treat the depression in all sort of way. Clinical evidence is required to provide backing to the safety and effectiveness of herbs and phytochemicals alone or in combination with currently available drugs to overcome the reported side effects during the treatment of depression.

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The Effects ofRhodiola roseaL. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms

Cited by 66 publications

References 22 publications

Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho‐oncologic relevance

Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho‐oncologic relevance

Rhodiola rosea L. and Alzheimer's Disease: From Farm to Pharmacy

Medicinal Herbs and Phytochemicals Used in the Treatment of Depression: A Review

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