The effects of hypothyroidism on strength–duration properties of peripheral nerve

Yerdelen, Deniz; Ertorer, Melek Eda; Koç, Filiz

doi:10.1016/j.jns.2010.03.026

Cited by 17 publications

(12 citation statements)

References 15 publications

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“…Previous studies reported that hypothyroidism and subclinical hypothyroidism were strongly associated with peripheral neuropathy and neuromyopathy [11,14]. The strength- Article Thieme duration properties of peripheral nerve could be improved after the hormone replacement therapy in hypothyroid patients [12]. However, the results of multiple linear regression models in our study showed that amplitudes of several nerves in male and female were positively correlated with the serum levels of TSH.…”

Section: Discussioncontrasting

confidence: 69%

“…Previous studies revealed that subclinical hypothyroidism (SCH) and hypothyroidism were correlated with neuropathy or abnormal nerve conduction amplitude and velocity despite the indefinite pathophysiological mechanisms [11][12][13][14]. A cross-sectional study reported that the thyroid stimulating hormone (TSH) level, a sensitive indicator of SCH, was associated with clinical DPN and might be a clinical predictor for DPN in T2DM patients [15].…”

Section: Introductionmentioning

confidence: 99%

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The Association Between the Levels of Thyroid Hormones and Peripheral Nerve Conduction in Patients with Type 2 Diabetes Mellitus

Zhu

Yang

2018

Exp Clin Endocrinol Diabetes

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Section: Discussioncontrasting

confidence: 69%

Section: Introductionmentioning

confidence: 99%

The Association Between the Levels of Thyroid Hormones and Peripheral Nerve Conduction in Patients with Type 2 Diabetes Mellitus

Zhu

Yang

2018

Exp Clin Endocrinol Diabetes

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“…The patients with hypothyroidism have complaint such as paresthesia, myalgia and muscle weakness. 21 A number of studies reported that hypothyroidism is associated with an increased risk of peripheral neuropathy 22 . CTS is the most common neuropathy associated with hypothyroidism.…”

Section: Discussionmentioning

confidence: 99%

“…CTS is the most common neuropathy associated with hypothyroidism. 22,23 Hypothyroidism may cause to development of CTS leading alterations of fluid balance and peripheral tissue edema 11 . We did not find a trial evaluating serum T3, T4 and TSH values in male patients with CTS in literature.…”

Section: Discussionmentioning

confidence: 99%

•Levels of endocrine hormones and lipids in male patients with carpal tunnel syndrome

Uzkeser¹

2011

Dicle Med J

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ÖZETAmaç: Bu çalışma karpal tünel sendromlu (KTS) erkek hastalarda endokrin hormon ve lipid düzeyleriyle klinik özellikler arasındaki ilişkiyi belirlemek amacıyla düzen-lendi. Gereç ve yöntem:Çalışmaya 15 erkek KTS hastası ve 16 sağlıklı kontrol dahil edildi. Serum serbest T3, serbest T4, tiroid stimüle edici hormon (TSH), serbest testosteron, dehidroepiandrosteron sülfat, trigliserid ve total kolesterol düzeyleri analiz edildi. Klinik değerlendirmede semptom şiddeti ve el fonksiyonları Boston Karpal Tünel Anketi ile belirlendi. Bulgular:Karpal tünel sendromu hastalarında serum serbest T3, serbest T4, TSH, serbest testosteron, dehidroepiandrosteron sülfat, trigliserid ve total kolesterol değerleri kontrollerle benzer düzeylerdeydi (p> 0.05). KTS hastalarında klinik özellikler ile laboratuar parametreleri arasında da istatistiksel olarak anlamlı bir korelasyon yoktu (p> 0.05).Sonuç: Karpal tünel sendromu olan erkek hastalarda serum serbest T3, serbest T4, TSH, serbest testosteron, dehidroepiandrosteron sülfat, trigliserid ve total kolesterol düzeyleri normal aralıkta görülmektedir. Kadın ve erkek hastalarda total kolesterol ve trigliserid gibi lipid düzeyleri ve endokrin faktörler ile KTS arasındaki ilişkiyi araştıracak yeni çalışmaların yapılması gerekmektedir.Anahtar kelimeler: Karpal tünel sendromu, tiroid hormonu, testosteron, lipid düzeyleri ABSTRACT Objectives: This study was performed to evaluate the relationship between endocrine hormones, lipid levels and clinical parameters in male patients with carpal tunnel syndrome (CTS). Materials and methods:Fifteen male patients with CTS and 16 healthy controls were included in the study. Serum free T3, free T4, thyroid-stimulating hormone (TSH), free testosterone, dehydroepiandrosterone sulfate, triglyceride and total cholesterol levels were analyzed. Symptom severity and hand function were assessed using the Boston Carpal Tunnel Questionnaire in clinical examination.Results: Serum free T3, free T4, TSH, free testosterone, dehydroepiandrosterone sulfate, triglyceride and total cholesterol levels were similar between CTS patients and controls (p> 0.05). Also, there was no statistically significant correlation between laboratory parameters and clinical characteristics in patients with CTS (p> 0.05). Conclusion:The serum free T3, free T4, TSH, free testosterone, dehydroepiandrosterone sulfate, triglyceride and total cholesterol levels seem within normal range in male CTS patients. Further studies are needed to investigate association endocrine factors, lipid levels such as triglyceride and total cholesterol with CTS in male and female patients.

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“…The down regulation of INa p and Ih are likely compensatory, serving to maintain axonal excitability. Another possibility is that carbamazepine that was used in the patient 1 might have suppressed transient and persistent Na + currents (Kuwabara et al, 2005;Park et al, 2014;Yerdelen and Koc, 2014). Still, given the consistently reduced SDTC and refractoriness in our patients who did not receive a Na + channel blocker, the pharmacological effect on excitability measures is likely to be minimal.…”

Section: Involvement Of Cable Properties and Channels Not Considered mentioning

confidence: 92%

Abnormal gating of axonal slow potassium current in cramp-fasciculation syndrome

Shimatani¹,

Nodera²,

Shibuta³

et al. 2015

Clinical Neurophysiology

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The effects of hypothyroidism on strength–duration properties of peripheral nerve

Cited by 17 publications

References 15 publications

The Association Between the Levels of Thyroid Hormones and Peripheral Nerve Conduction in Patients with Type 2 Diabetes Mellitus

The Association Between the Levels of Thyroid Hormones and Peripheral Nerve Conduction in Patients with Type 2 Diabetes Mellitus

•Levels of endocrine hormones and lipids in male patients with carpal tunnel syndrome

Abnormal gating of axonal slow potassium current in cramp-fasciculation syndrome

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