2015
DOI: 10.1016/j.clinph.2014.09.013
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Abnormal gating of axonal slow potassium current in cramp-fasciculation syndrome

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Cited by 12 publications
(8 citation statements)
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“…A previous study by Kiernan and Bostock [34] did not detect these alterations, probably because they did not use the extended stimulation protocol with prolonged and stronger hyperpolarizing conditioning pulses used by Czesnik and coworkers [35]. Shimatani et al [37] reported a change in slow potassium channel activity in four patients with frequent cramps, but since motor unit multiplets were illustrated in their electromyography (EMG) recordings it is suggested that their patients had neuromyotonia, an autoimmune disorder, rather than ICFS.…”
Section: Idiopathic Cramp-fasciculation Syndromementioning
confidence: 97%
See 1 more Smart Citation
“…A previous study by Kiernan and Bostock [34] did not detect these alterations, probably because they did not use the extended stimulation protocol with prolonged and stronger hyperpolarizing conditioning pulses used by Czesnik and coworkers [35]. Shimatani et al [37] reported a change in slow potassium channel activity in four patients with frequent cramps, but since motor unit multiplets were illustrated in their electromyography (EMG) recordings it is suggested that their patients had neuromyotonia, an autoimmune disorder, rather than ICFS.…”
Section: Idiopathic Cramp-fasciculation Syndromementioning
confidence: 97%
“…Shimatani et al . reported a change in slow potassium channel activity in four patients with frequent cramps, but since motor unit multiplets were illustrated in their electromyography (EMG) recordings it is suggested that their patients had neuromyotonia, an autoimmune disorder, rather than ICFS.…”
Section: Idiopathic Cramp‐fasciculation Syndromementioning
confidence: 99%
“…Cramps may also develop during high-rate repetitive nerve stimulation 66. Benign fasciculations and cramp-fasciculation syndrome can be regarded as part of a larger spectrum of disease that also incorporates acquired auto-immune neuromyotonia 67. Indeed, antibodies to the voltage-gated potassium channel complex have been identified in 32% of patients with cramp-fasciculation syndrome,68 including leucine-rich glioma-inactivated-1 antibodies in a small, tested subset of patients.…”
Section: Benign Fasciculation and Cramp Fasciculation Syndromesmentioning
confidence: 99%
“…The threshold is related to membrane potential, as membrane hyperpolarization increases and depolarization decreases the threshold. Additional factors such as nerve ischemia may also impact on threshold, and, consequently, assessment of axonal [136,137] I/V = current threshold relationship; TEh = threshold electrotonus (hyperpolarizing direction); TEd = threshold electrotonus (depolarizing direction); RRP = relative refractory period excitability parameters (discussed later) is required to provide a clear depiction of membrane excitability [21][22][23][24][25].…”
Section: The Clinical Assessment Of Axonal Excitabilitymentioning
confidence: 99%