The Effects of Hyperhomocysteinemia on the Microcirculation of Skin Flaps

Kamburoğlu, Haldun Onuralp; Uzun, Hakan; Bitik, Ozan; Ersoy, Umut S.; Öcal, Engin; Çalş, Mert; Sönmez, Erhan; Şafak, Tunç; Pnar, Asl; Atilla, Pergin

doi:10.1097/prs.0b013e318221db4d

Cited by 2 publications

(3 citation statements)

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“…In the present study, the plasma total homocysteine level was increased following ingestion of 1% methionine diet, which confirms previous data demonstrating that hyperhomocysteinemia could be induced by a high methionine diet [5, 6]. No difference seen in the mean total food intake in all groups suggests that the intake of methionine in all groups except in the control group was similar.…”

Section: Discussionsupporting

confidence: 91%

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Palm Tocotrienol-Rich Fraction Improves Vascular Proatherosclerotic Changes in Hyperhomocysteinemic Rats

Norsidah

Asmadi

Ayob³

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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This study investigated the effects of palm tocotrienol-rich fraction (TRF) on aortic proatherosclerotic changes in rats fed with a high methionine diet. Forty-two male Wistar rats were divided into six groups. The first group was the control (fed with a basal diet). Another five groups were fed with 1% methionine diet for 10 weeks. From week 6 onward, folate (8 mg/kg diet) or palm TRF (30, 60, and 150 mg/kg diets) was added into the diet of the last four rat groups, respectively. The high methionine diet raised the plasma total homocysteine and aortic lipid peroxidation, which were reduced by the palm TRF and folate supplementations. Plasma nitric oxide was reduced in the high methionine group compared to the control (3.72 ± 0.57 versus 6.65 ± 0.53 μmol/L, P < 0.05), which reduction was reversed by the palm TRF (60 and 150 mg/kg) and folate supplementations. The increased aortic vascular cell adhesion molecule-1 expression in the methionine group (2.58 ± 0.29) was significantly reduced by the folate (1.38 ± 0.18) and palm TRF at 150 mg/kg (1.19 ± 0.23). Palm TRF was comparable to folate in reducing high methionine diet-induced plasma hyperhomocysteinemia, aortic oxidative stress, and inflammatory changes in rats.

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Section: Discussionsupporting

confidence: 91%

“…Many studies have shown that hyperhomocysteinemia can be induced by feeding experimental animals with a high methionine diet [5, 6]. Hyperhomocysteinemia enhances production of a reactive oxygen species (ROS), leading to increased oxidative stress [7] which then reduces nitric oxide (NO) production [8].…”

Section: Introductionmentioning

confidence: 99%

Palm Tocotrienol-Rich Fraction Improves Vascular Proatherosclerotic Changes in Hyperhomocysteinemic Rats

Norsidah

Asmadi

Ayob³

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…It has been reported that hyperhomocysteinemia is associated with microvascular failure. ( 27 ) Hcy can be methylated to form methionine, catalyzed by the enzyme methionine synthase and folic acid and vitamin B 12 cofactors. ( 28 ) The conversion of Hcy to cystathionine is catalyzed by systathionine β-synthase in the liver.…”

Section: Discussionmentioning

confidence: 99%

The effect of B vitamin supplementation on wound healing in type 2 diabetic mice

Mochizuki

Takano

Sugano

et al. 2016

J. Clin. Biochem. Nutr.

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The aim of this study was to test the effects of B-group vitamin supplements on wound healing in diabetic mice. The mice in the experimental group were treated daily with 1 g/L B6, 1.25 mg/L B12, and 62.5 mg/L folic acid in their drinking water. Full-thickness excision wounds were created with 6-mm skin biopsy punches. Each wound closure was digitally photographed. Beginning on day 3 after wounding, the wound area in the diabetic mice was statistically larger than that of normal mice (p<0.05 vs diabetic mice). The diabetic mice treated with B vitamins displayed accelerated wound closure on day 3 (wound area 42.8 ± 11.3%, p<0.05). On day 9 after wounding, the wound area in the diabetic mice was also statistically larger than that of normal mice (p<0.05 vs diabetic mice). The diabetic mice treated with B vitamins displayed accelerated wound closure on day 3 (wound area 13.2 ± 16.8%, p<0.05). In addition, the high glucose level in the diabetic animals decreased significantly in response to B vitamin treatment. In conclusion, the results of this study indicate that B vitamin supplementation may improve wound healing in diabetic mice.

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The Effects of Hyperhomocysteinemia on the Microcirculation of Skin Flaps

Abstract: The authors demonstrated, for the first time, that hyperhomocysteinemia severely suppressed the microvasculature of skin flaps, as shown by increased flap necrosis and reduced microvessel calibration in the experimental group.

Cited by 2 publications

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Palm Tocotrienol-Rich Fraction Improves Vascular Proatherosclerotic Changes in Hyperhomocysteinemic Rats

Palm Tocotrienol-Rich Fraction Improves Vascular Proatherosclerotic Changes in Hyperhomocysteinemic Rats

The effect of B vitamin supplementation on wound healing in type 2 diabetic mice

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