The Effects of Human Albumin, Normal Saline and Jambi’s Honey as Anti-Adhesive Agent in Laparotomized Rats

Abstract

Postoperative peritoneal adhesion formation after surgery is result of peritoneal surface trauma and tissue ischemia. antiadhesive agent is one of methods to reduce tissue adhesion. Honey has a long history medicine as anti-inflammatory, antibacterial and wound healing agent. Thirty-six healthy male wistar rats divide into six group. Control group as group A, normal saline as group B, minimal dose of honey as Group C, maximal dose of honey as group D, minimal dose of human albumin as group E and maximal dose of Human Albumin as Group F. the identification Adhesio in macroscopic based on PAI score. The microscopic based on inflammatory cell and, fibroblast cell was assessed after 10 days. the comparison in two group based on PAI was significant in group Avs C (p value: 0.02), A Vs D (p-value: .04), AVs E (p-value: .04) and AVs F (p-value: .04), but in all groups was not significant in microscopic appearance. Jambi's honey and Human Albumin has an anti-adhesive effect in clean wound without contaminated.