The effects of high-frequency inflation and high-frequency deflation on respiration in rabbits

Homma, Ikuo; Onimaru, Hiroshi; Oouchi, Michiko; Ichikawa, Santa

doi:10.1016/0304-3940(85)90595-6

Cited by 8 publications

(5 citation statements)

References 20 publications

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“…It can be summarized that the prolongation of this period within the E2 stage was respon sible for the TE prolongation previously reported (Homma et al 1985).…”

Section: Figuresupporting

confidence: 61%

“…The neuromuscular activities were amplified (AB-621G, Nihon Kohden, Tokyo) and recorded on a tape recorder (R-71, TEAC, Tokyo). HFI stimulation was generated as previously reported (Homma et al 1985). In brief, a moving coil in a sealed box was driven by triangular-shaped electrical pulses.…”

Section: Methodsmentioning

confidence: 99%

“…A mode was seen in the cross-correlogram between positive pressure pulses, designated high-frequency inflation (HFI), and vagal afferent impulses from PSR. It was also reported that HFI decreased respiratory fre quency by prolongation of the expiratory duration (Homma et al 1985). However, the effect of HFI on expiratory activity has not been reported.…”

mentioning

confidence: 96%

“…Irritant receptor afferents are also known to induce augmented breaths (Glogowska et al 1972). There are several reports indicating that PSR and irritant afferents influence the onset of inspiratory activity and thus have a significant effect on expiratory duration (Stark and Frantz 1979 ; Rao et al 1981 ;Homma et al 1985;Trippenbach et al 1985). On the other hand, less attention has directed toward the effect of vagal afferents on expiratory activity (Bishop 1963: Farber 1982.…”

mentioning

confidence: 99%

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Effects of high-frequency inflation (HFI) on expiratory activity.

Sibuya

Kanamaru

Isobe

et al. 1988

Tohoku J. Exp. Med.

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It has been reported that triangular-shaped positive pressure pulses applied to the airway (high-frequency inflation, HFI) stimulates pulmonary stretch receptors and prolongs expiratory duration. In the present experiment, changes in the integrated curve of expiratory activity induced by HFI were investigated. Duration until the onset of the expiratory activity (El stage) was unchanged. In the E2 stage, the initial ascending slope became steeper and higher peaks were reached during HFI stimulation. The period from the onset of the slope to the peak, previously designated the stage of active expiration (Ea stage), showed no consistent change in duration and remained unchanged on average. The period after the peak until the onset of the following inspiratory activity was consistently prolonged. This period was designated the declining stage of expiration (Ed stage). expiratory activity ; high-frequency inflation ; pulmonary stretch receptors ; vagal afferents ; expiratory duration 65

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“…It can be summarized that the prolongation of this period within the E2 stage was respon sible for the TE prolongation previously reported (Homma et al 1985).…”

Section: Figuresupporting

confidence: 61%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 96%

mentioning

confidence: 99%

See 2 more Smart Citations

Effects of high-frequency inflation (HFI) on expiratory activity.

Sibuya

Kanamaru

Isobe

et al. 1988

Tohoku J. Exp. Med.

Self Cite

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“…Other workers (e.g. Homma, Onimaru, Oouchi & Ichikawa, 1985) have used rapidly repeated ramps of inflation or deflation. This form of HFV may be considered as a high-frequency series ofpulses of inflation or deflation; and their results are entirely in agreement, both in terms of reflexes (Homma, Isobe, Onimaru & Oouchi, 1986) and receptor activity (Homma, Isobe, Iwase, Onimaru & Sibuya, 1987) with those we obtained with single pulses in previous experiments (Davies & Roumy, 1982).…”

Section: Discussionmentioning

confidence: 99%

The Effect of High‐frequency Ventilation on Pattern of Breathing of Anaesthetized Rabbits

1988

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SUMMARYThe lungs of anaesthetized rabbits were ventilated with a frequency of 30 Hz and a displacement of 5 ml. High-frequency ventilation (HFV) was superimposed on static inflation or deflation pressures of 2 5 and 5 cmH20 and was maintained for 10 s. Changes in pattern of breathing in response to this procedure were recorded before and during block of pulmonary stretch receptors by SO2. With lung stretch receptors intact apnoea or extended duration of expiration demonstrated the predominant role of pulmonary stretch receptors in the response to HFV. Block of stretch receptors exposed effects of other pulmonary afferents, presumably rapidly adapting receptors, during HFV, and demonstrated the influence of their sustained stimulation on pattern of breathing as augmented breaths and the reduction of duration of expiration. High-frequency ventilation may represent a useful experimental method of stimulating rapidly adapting receptors.

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Blockade of pulmonary stretch receptors reinforces diaphragmatic activity during high-frequency oscillatory ventilation

Kohl

Koller

1988

Pflugers Arch.

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During apneic periods elicited by high-frequency oscillatory ventilation (HFOV) a tonic diaphragmatic activity was observed, contrasting with the absence of diaphragmatic activity during apnea induced by lung inflation. To clarify the mechanism underlying the persistence of the diaphragmatic activity during HFOV-induced arrest of breathing the reflex responses to short periods of HFOV, and to periods of lung inflation with airway pressure (Paw) equal to the mean Paw and/or to maximal Paw during HFOV were examined both before and after the blockade of slowly adapting stretch receptors (SR) by inhalation of sulphur dioxide (SO2) in anaesthetized rabbits. In animals with intact SR, the HFOV-induced reflex apnea lasted longer than that induced by lung inflation, the associated diaphragmatic activity being in the most cases higher than the diaphragmatic activity during quiet expiration; inflation, however, completely inhibited diaphragmatic activity. After blockade of SR, spontaneous breathing continued during periods of lung inflation, i.e., the Hering-Breuer inflation reflex was abolished, whereas HFOV still led to a cessation of spontaneous breathing, the associated diaphragmatic activity even exceeding the level observed during quiet inspiration. From these results we conclude that only one part of the reflex response to HFOV is due to SR-stimulation and that in addition other vagal pulmonary receptors (irritant- and/or C-fibre-receptors) are involved. The stimulation of the latter counterbalances the concomitant stimulation of SR, giving rise to the tonic activity of the diaphragm.

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The effects of high-frequency inflation and high-frequency deflation on respiration in rabbits

Cited by 8 publications

References 20 publications

Effects of high-frequency inflation (HFI) on expiratory activity.

Effects of high-frequency inflation (HFI) on expiratory activity.

The Effect of High‐frequency Ventilation on Pattern of Breathing of Anaesthetized Rabbits

Blockade of pulmonary stretch receptors reinforces diaphragmatic activity during high-frequency oscillatory ventilation

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