The effects of high dose of parathyroid hormone on fetal osteoclasts and their precursors in vivo: An ultrastructural‐cytochemical study

Abstract

Our results revealed the progression of maturation from young preosteoclasts to osteoclasts. An existence of a peculiar binucleated preosteoclasts suggested one of the processes for multinucleation of the osteoclast. Quite remarkable osteoclastic hyperactivities were obviously the effects of high dose PTH. Our results also indicated the endophagocytic ability of the osteoclast. How PTH affected the osteoclasts and their precursors in the diaphyseal bone marrow can be speculated.

Ultrastructural Cytochemical and Ultrastructural Morphological Differences Between Human Multinucleated Giant Cells Elicited by Wear Particles from Hip Prostheses and Artificial Ligaments at the Knee

“…Studying fetal limb buds after administration of high-dose parathyroid hormone, Isaki and Hanaoka [32] ultrastructurally demonstrated osteoclasts with cytoplasmic vacuoles that contained a fragment of calcified chondroid bar and portions We also noted ultrastructural cytochemical variation in reactive multinucleated giant cells that exist in different environments, such as those with and without osteolysis, and with exposure to different foreign materials. These ultrastructural differences between giant cells near active osteolysis and near failed L-K ligaments suggest that environments involving bone resorption, including wear particles, affect the ultrastructure of multinucleated giant cells.…”