The effects of hemodialysis and peritoneal dialysis on serum homocysteine and C-reactive protein levels

Borazan, Ali; Aydemır, Selim; Sert, Mehmet; Yılmaz, Ahmet

doi:10.1080/09629350400008786

Cited by 22 publications

(17 citation statements)

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“…While our study was conducted at an early stage of the CAPD, Borazan et al's study showed that the average CAPD duration was 17.3 months. [34] In another study, Borazan et al [35] showed that CRP levels were elevated in the beginning and in the third months of the CAPD treatment when compared to control patients. They found no further increase after three months in CRP levels.…”

Section: Discussionmentioning

confidence: 99%

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Positive Correlation of CRP and Fibrinogen Levels as Cardiovascular Risk Factors in Early Stage of Continuous Ambulatory Peritoneal Dialysis Patients

et al. 2008

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We aimed to study the relationship between the C-reactive protein (CRP), albumin, and fibrinogen as cardiovascular risk factors in continuous ambulatory peritoneal dialysis (CAPD) patients, in the early stage of their therapy. The study included 21 CAPD patients as the study group (SG) and age-and sexmatched 21 healthy patients as the control group (CG). History and physical exam data were obtained for all cases, and demographic baseline characteristics were taken. Twelve-hour fasting serum levels of glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglyceride, total protein, albumin, hemoglobin, CRP, and fibrinogen were obtained.There was no statistically significant difference between the SG and CG in baseline characteristics, including age, sex, body mass index (BMI), smoking, and family history of cardiovascular disease. However, diabetes mellitus (DM) and hypertension (HTN) were significantly more common among the study group. The average total protein, albumin, and hemoglobin levels were significantly lower, and the CRP and fibrinogen levels were significantly higher (p < 0.001) in the SG. A positive correlation was seen (r = 0.443, p < 0.05) among CRP and fibrinogen levels in SG. There was no correlation among the other parameters in SG. For CG, there was no correlation seen for any studied parameters. When patients with and without cardiovascular disease (CVD) were compared, no correlation was seen between CRP and other parameters. A positive correlation of CRP and fibrinogen levels as cardiovascular risk factors was shown in early stage

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Section: Discussionmentioning

confidence: 99%

“…Albumin levels were low in 80.9% of CAPD patients. The Borazan et al study [34] included 16 CAPD and 52 hemodialysis patients. They showed that CRP is elevated in 77.7% of CAPD patients and 48.1% of hemodialysis patients.…”

Section: Discussionmentioning

confidence: 99%

Positive Correlation of CRP and Fibrinogen Levels as Cardiovascular Risk Factors in Early Stage of Continuous Ambulatory Peritoneal Dialysis Patients

et al. 2008

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“…The assumed SD for IL-6 for the power calculation was 2.6 pg/ml (21). The sample size calculation to detect a 25% relative difference in the serum IL-6 concentration at the end of the study between both groups for an ␣ value of 0.05 and a ␤ value of 0.90 showed a need for a minimum of 26 individuals in each group.…”

Section: Discussionmentioning

confidence: 99%

Effect of Phosphate Binders on Serum Inflammatory Profile, Soluble CD14, and Endotoxin Levels in Hemodialysis Patients

Navarro‐González¹,

Mora‐Fernández²,

Fuentes³

et al. 2011

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives Hyperphosphatemia and subclinical endotoxemia are important sources of inflammation in HD. Proinflammatory cytokines are strong correlates of soluble CD14 (sCD14) concentrations, an independent predictor of mortality in this population. We evaluated the effects of calcium acetate and sevelamer hydrochloride on serum inflammatory profile, endotoxin concentrations, and sCD14 levels in HD patients.Design, setting, participants, & measurements Prospective, randomized, open-label, parallel design trial. Fiftynine stable HD patients, 30 receiving sevelamer, and 29 receiving calcium acetate were evaluated. Serum levels of inflammatory parameters (high-sensitivity C-reactive protein [hs-CRP], TNF-␣, interleukin (IL)-1, -6, -10, and -18), as well as endotoxin and sCD14 concentrations, were measured at baseline and after 3 months of therapy.Results Serum IL-6 increased in patients receiving calcium acetate, whereas hs-CRP and IL-6 significantly decreased in subjects treated with sevelamer, with IL-10 experiencing a trend to increase (P ϭ 0.052). Serum endotoxin and sCD14 levels did not change after treatment with calcium acetate. However, these parameters decreased by 22.6% and 15.2%, respectively (P Ͻ 0.01), in patients receiving sevelamer. Multiple regression analysis showed that variation in serum endotoxin concentrations was the strongest factor associated with IL-6 change, whereas the only variables independently associated with changes in sCD14 levels were the variations in serum IL-6 and endotoxin concentrations.Conclusions Administration of the noncalcium phosphate binder sevelamer to maintenance HD patients is associated with a significant decrease in hs-CRP, IL-6, serum endotoxin levels and sCD14 concentrations.

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“…Experimental evidence indicates that serum CRP levels increased during PD (32)(33)(34). Glucose and glucose degradation products in the PD solutions can increase CRP levels of PD patients (35,36).…”

Section: Discussionmentioning

confidence: 99%

Relationship between CRP Polymorphism and Cardiovascular Events in Chinese Peritoneal Dialysis Patients

Poon

Szeto

Kwan

et al. 2012

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives The single-nucleotide polymorphism (SNP) -717A→G substitution, rs2794521, was found in the promoter of the C-reactive protein (CRP) gene. Functional studies showed that A allele promoter has higher transcriptional activity than the G allele. This study investigated the association between this SNP and the outcome of Chinese patients undergoing peritoneal dialysis (PD).Design, setting, participants, & measurements The study included 441 new PD patients (232 men; mean age 6 SD, 56.7613.5 years). CRP genotyping was determined; patients were followed for 41.3618.3 months for cardiovascular events.Results For the entire cohort, 5-year event-free survival rates did not differ between the AA and AG/GG groups (35.7% and 31.9%, respectively; P=0.64). However, there was significant interaction between plasma cholesterol levels and CRP genotype groups on event-free survival (P=0.04 for interaction). For patients with cholesterol levels of 200 mg/dl or greater, the 5-year event-free survival rate in the AG/GG group was significantly better than that in the AA group (54.7% versus 40.0%; P=0.04), whereas there was no difference in event-free survival between genotype groups for patients with cholesterol levels less than 200 mg/dl.Conclusions CRP gene -717AG or GG genotypes is associated with cardiovascular benefit to Chinese PD patients with cholesterol levels of 200 mg/dl or greater. These findings suggest a complex interaction among cholesterol, CRP, and cardiovascular disease in PD patients.

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The effects of hemodialysis and peritoneal dialysis on serum homocysteine and C-reactive protein levels

Cited by 22 publications

References 16 publications

Positive Correlation of CRP and Fibrinogen Levels as Cardiovascular Risk Factors in Early Stage of Continuous Ambulatory Peritoneal Dialysis Patients

Positive Correlation of CRP and Fibrinogen Levels as Cardiovascular Risk Factors in Early Stage of Continuous Ambulatory Peritoneal Dialysis Patients

Effect of Phosphate Binders on Serum Inflammatory Profile, Soluble CD14, and Endotoxin Levels in Hemodialysis Patients

Relationship between CRP Polymorphism and Cardiovascular Events in Chinese Peritoneal Dialysis Patients

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