Positive Correlation of CRP and Fibrinogen Levels as Cardiovascular Risk Factors in Early Stage of Continuous Ambulatory Peritoneal Dialysis Patients

Abstract

We aimed to study the relationship between the C-reactive protein (CRP), albumin, and fibrinogen as cardiovascular risk factors in continuous ambulatory peritoneal dialysis (CAPD) patients, in the early stage of their therapy. The study included 21 CAPD patients as the study group (SG) and age-and sexmatched 21 healthy patients as the control group (CG). History and physical exam data were obtained for all cases, and demographic baseline characteristics were taken. Twelve-hour fasting serum levels of glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglyceride, total protein, albumin, hemoglobin, CRP, and fibrinogen were obtained.There was no statistically significant difference between the SG and CG in baseline characteristics, including age, sex, body mass index (BMI), smoking, and family history of cardiovascular disease. However, diabetes mellitus (DM) and hypertension (HTN) were significantly more common among the study group. The average total protein, albumin, and hemoglobin levels were significantly lower, and the CRP and fibrinogen levels were significantly higher (p < 0.001) in the SG. A positive correlation was seen (r = 0.443, p < 0.05) among CRP and fibrinogen levels in SG. There was no correlation among the other parameters in SG. For CG, there was no correlation seen for any studied parameters. When patients with and without cardiovascular disease (CVD) were compared, no correlation was seen between CRP and other parameters. A positive correlation of CRP and fibrinogen levels as cardiovascular risk factors was shown in early stage

Survival Advantage of Normal Weight in Peritoneal Dialysis Patients

“…An elevated level of CRP, which was a marker of inflammation, was a risk factor for morbidity and mortality in the general population 21 ; and in PD patients, CRP was strongly associated with cardiovascular disease. 22,23 Therefore, we confirm that high levels of CRP in overweight patients are associated with bad outcomes. Ohkuma et al further demonstrated that Lp(a) and CRP levels have an important role in carotid atherosclerosis in PD patients.…”

Cardiovascular disease markers in women with polycystic ovary syndrome with emphasis on asymmetric dimethylarginine and homocysteine

“…Elevated hsCRP was reported as a proinflammatory agent and a risk factor for the CV events 14. The present study demonstrated that circulating hsCRP levels were higher in women with PCOS compared with controls.…”

“…Similarly, raised fibrinogen concentration has been associated with an increased risk of ischemic heart disease and atherosclerosis. Fibrinogen may promote CVD by a variety of mechanisms, including increased blood viscosity, thrombus formation, or platelet aggregation 14. The aim of the present study was to investigate the plasma markers of CVD in Saudi women with PCOS.…”

“…Also, hsCRP has been shown to be a good predictor of vascular events 14. In addition to being a marker of inflammation, there is evidence that hsCRP may have a direct role in atherogenesis via adhesion molecule expression, complement activation, and mediation of LDL uptake by macrophages 15.…”

Evaluation of Ultrasensitive C-Reactive Protein as a Cardiovascular Risk Marker in Pediatric Patients with End-Stage Renal Disease on Peritoneal Dialysis

“…For adult patients with chronic kidney disease and on renal replacement therapy, the utility of USCRP as a prognostic tool for the evolution of the kidney disease, cardiovascular risk factors, and mortality has been well established [45,46]. The first studies established the utility of measuring baseline USCRP as a prognostic indicator, but current reports for adult populations indicate that the evolution of USCRP is a better indicator than an isolated measurement [28].…”