The effects of growing up on a farm on adult lung function and allergic phenotypes: an international population-based study

Campbell, Brittany; Rahérison, Chantal; Lodge, Caroline; Lowe, Adrian J.; Gíslason, Þórarinn; Heinrich, Joachim; Sunyer, Jordi; Real, Francisco Gómez; Norbäck, Dan; Matheson, Melanie C.; Wjst, Matthias; Dratva, Julia; Marco, Roberto de; Jarvis, Déborah; Schlünssen, Vivi; Janson, Christer; Leynaert, Bénédicte; Svanes, Cecilie; Dharmage, Shyamali C.

doi:10.1136/thoraxjnl-2015-208154

Cited by 45 publications

(39 citation statements)

References 40 publications

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“…These findings were supported by a large population-based study where subjects living on a farm with livestock exposure during the first 5 years of life had significantly reduced rates of allergic rhinitis and symptoms in adulthood compared to those who had a city-based childhood, independent of differences in farming structure [30]. In agreement with these studies, the European Community Respiratory Health Survey II also reported a lower prevalence of atopic sensitization, atopic asthma, and atopic rhinitis in adulthood for subjects with farm exposure before 5 years of age as compared to those with an urban childhood [31]. …”

Section: First-generation International Immigrantssupporting

confidence: 70%

Effects of Migration on Allergic Diseases

Tham

Zhu

2018

Int Arch Allergy Immunol

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Studies in migrant populations provide vital opportunities to investigate the role of environmental factors in the pathogenesis of allergic disorders. Differences in allergy prevalence have been observed between migrants and native-born subjects living in the same geographical location. Immigrants who migrate from less affluent countries with lower allergy prevalence tend to have a lower prevalence of allergic disorders compared to native-born residents of the more affluent host country. The patterns of allergic disease prevalence also differ between first- and second-generation migrants. The timing of migration in relation to birth, age at migration, and duration of residence in the host country also influence one’s atopic risk. A complex interplay of multiple environmental, socioeconomic, and cultural factors is likely responsible for these observed differences. Further research into the roles of various risk factors in modulating differences in allergic disease prevalence between migrant and native populations will enhance our understanding of the complex gene-environment interactions involved in the pathogenesis of allergic disorders.

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Section: First-generation International Immigrantssupporting

confidence: 70%

Effects of Migration on Allergic Diseases

Tham

Zhu

2018

Int Arch Allergy Immunol

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“…It is remarkable that early life exposure to farming environments has sustained effects on adult atopic sensitisation. However, added effects on asthma, BHR and nasal symptoms as suggested by previous studies in childhood6 and adulthood7 are not supported by the present study 1…”

contrasting

confidence: 99%

“…In Thorax , Campbell et al 1 report an association of growing up on a farm with better adult lung function. On closer investigation, this effect was confined to the FEV 1 in female participants in the study.…”

mentioning

confidence: 99%

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Do farm-grown lungs breathe better?

Genuneit

2016

Thorax

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“…A number of studies have demonstrated that growing up on a farm can be protective for childhood asthma and allergies (Naleway, 2004, Von Ehrenstein et al, 2000, Klintberg et al, 2001). There can also be a persistent protective effect of growing up on a farm (Campbell et al, 2015). In our study, we have no information on postnatal exposure to the farm environment, just information on the area of the current home, so we cannot specifically evaluate the effect of the farm environment.…”

Section: Or(95%ci) Or(95%ci) Or(95%ci) Or(95%ci) Or(95%ci) Or(95%cimentioning

confidence: 99%

Associations between parental health, early life factors and asthma, rhinitis and eczema among pre-school children in Chongqing, China

Wang

Li²,

Yu³

et al. 2016

GJHS

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Purpose: To study associations between parental factors and children's asthma, rhinitis and eczema. Methods:Parents of 3-6 years old children in Chongqing, China answered a questionnaire on parental history of asthma/allergies, parental symptoms and children's asthma, rhinitis and eczema. Associations were analyzed by multiple logistic regression. Results:Among 4250 children (response rate: 74.5%), 8.4% had doctor-diagnosed asthma (DD asthma); 6.2% doctor-diagnosed allergic rhinitis (DD rhinitis); 20.4% wheeze; 19.4% cough; 37.9% rhinitis and 13.6% eczema. Among reporting parents (females 70.4%, males 29.6%), 16.2% were smokers; 47.4% reported rhinitis; 54.2% cough; 47.8% skin symptoms; 70.5% fatigue and 48.7% headache.Parental asthma/allergy was associated with children's DD asthma (OR=3.64) and DD rhinitis (OR=4.23). The associations were stronger for paternal asthma/allergy. Rural children had less DD rhinitis and current rhinitis. Children of mothers who were salespersons during pregnancy had more rhinitis (OR=1.49), children of teachers had more DD rhinitis (OR=2.09) and cough (OR=1.66), children of office workers had more DD rhinitis (OR=2.04) and children of mothers working in hospitals had more DD asthma (OR=2.47). Parental current symptoms were associated with wheeze, cough, rhinitis and eczema among the children with ORs ranging from 1.37 to 2.28 (all p<0.001). Conclusions:Parental asthma/allergy can be a risk factor for asthma or allergy, especially paternal asthma/allergy. Growing up in rural areas can be beneficial for rhinitis. Mother's occupation during pregnancy may influence children's asthma and rhinitis. In questionnaires studies on children's asthma or allergies, the reporting parent's gender and current medical symptoms may influence the results.Keywords: Pre-school children, asthma, rhinitis, eczema, home environment, rural childhood, occupation, validation, fatigue, headache IntroductionChildren's asthma and allergies has increased globally (Chen, 2003;Asher et al., 2006). The international Study of Asthma and Allergies in Childhood (ISAAC) has compared asthma and allergy between different countries (The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee, 1998), and analyzed associations with the home environment (Brunekreef et al., 2012). A recent review suggested that the rise in the prevalence of allergic disorders globally is associated with the whole civilizational progress, which is a complex interplay between immune response, invading pathogens, diversity of environmental factors and genetic background (Rutkowski et al., 2014).Parental factors can influence the prevalence of asthma, rhinitis and eczema in their children in different ways.

show abstract

The effects of growing up on a farm on adult lung function and allergic phenotypes: an international population-based study

Cited by 45 publications

References 40 publications

Effects of Migration on Allergic Diseases

Effects of Migration on Allergic Diseases

Do farm-grown lungs breathe better?

Associations between parental health, early life factors and asthma, rhinitis and eczema among pre-school children in Chongqing, China

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