The effects of ginsenoside Rg1 on chronic stress induced depression-like behaviors, BDNF expression and the phosphorylation of PKA and CREB in rats

Liu, Z.; Qi, Yanhua; Cheng, Zhiqiang; Zhu, Xiao Li; Fan, Chunhua; Yu, Shu

doi:10.1016/j.neuroscience.2016.02.050

Cited by 96 publications

(61 citation statements)

References 40 publications

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“…Our results showed that 5 weeks of CUMS exposure caused significant increases in immobility times in the forced swim test. Ginsenoside Rg1 pretreatment dramatically decreased immobility times while significantly increasing swimming times of CUMS-exposed rats, which were consistent with results from previous studies [44,45]. Similarly, in the open-field test, CUMS exposure significantly reduced the number of crossings and rearings, suggesting a loss of exploration and interest to a novel environment [46].…”

Section: Discussionsupporting

confidence: 90%

Ginsenoside Rg1 Prevents Chronic Stress-Induced Depression-Like Behaviors and Neuronal Structural Plasticity in Rats

Fan

Yang

et al. 2018

Cell Physiol Biochem

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Background/Aims: Ginsenoside Rg1 has been demonstrated to exhibit neuroprotective effects in various studies. This study aimed to investigate the neuronal mechanisms underlying the neuroprotective and antidepressant-like effects of ginsenoside Rg1 in a rat model of depression. Methods: Chronic unpredictable mild stress was used to induce depression-like behaviors in rats. Transmission electron microscopy was used to observe neuronal synapses within the basolateral amygdala (BLA). The expression of microRNA (miR)-134 in the BLA was verified by real-time quantitative PCR. Finally, the synaptic plasticity-associated proteins CAMP-response element binding protein (CREB) and brain-derived neurotrophic factor (BDNF) were detected by immunoblotting. Results: Results showed that chronic stress effectively induced depression-like behaviors in rats, which were associated with significant ultrastructural changes within BLA neurons. Moreover, chronic stress decreased the expression of miR-134 in the BLA, which was accompanied by decreased phosphorylation of CREB and decreased expression of BDNF. Remarkably, chronic administration of ginsenoside Rg1 (40 mg/kg, i.p., 5 weeks) significantly ameliorated the neuronal structural abnormalities and biochemical changes induced by chronic stress, as well as preventing depression-like behaviors in these rats. Conclusion: Results suggested that ginsenoside Rg1 may exhibit neuroprotection and antidepressant-like effects by activating the CREB-BDNF system within the BLA in this rat model of depression. Amelioration of depression-like behaviors by ginsenoside Rg1 appears to involve modulation of the synapse-associated factor miR-134 within the BLA. Therefore, these findings demonstrate some of the neuronal mechanisms associated with depression and the therapeutic potential of ginsenoside Rg1 for use in the treatment of depression in clinical trials.

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Section: Discussionsupporting

confidence: 90%

Ginsenoside Rg1 Prevents Chronic Stress-Induced Depression-Like Behaviors and Neuronal Structural Plasticity in Rats

Fan

Yang

et al. 2018

Cell Physiol Biochem

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“…Moreover, Rg1 was reported to ameliorate the behavioral abnormalities and modulates the hippocampal proteomics in triple transgenic female Alzheimer's mice (3xTg-AD) [38]. It is interesting to decipher the mechanistic avenue of how Rg1 to rescue the expression of FGF2 and BDNF in aging mice, especially in the hippocampus and prefrontal cortex, for chemokine or neurotrophins exerted extraordinary functions in the maintenance of neural activities [3]. One mechanism of action has been suggested for Rg1, which is based on its similarity to steroid hormones and can be agonist of its receptors [39,40].…”

Section: Discussionmentioning

confidence: 99%

“…Ginseng has been used as a food and ethnic medicine in China for centuries, for it is edible and easy to add to the diet such as stewed in water to make tea or added to recipes such as stir-fry and soup. Ginsenoside Rg1 is the most abundant ginsenoside identified in Panax ginseng and demonstrates the neuroprotective, antidepressant and antioxidant properties and estrogen-like activity in cell culture and animal models [1][2][3]. Rg1 have the capacity to regulate neurotransmitters, activate the learning and memory related signal pathways, and enhance synaptic plasticity and the long-term potentiation of postsynaptic potentials in the brain regions such as cortex and hippocampus [4,5].…”

Section: Introductionmentioning

confidence: 99%

Ginsenoside Rg1 ameliorates the cognitive deficits in D-galactose and AlCl₃-induced aging mice by restoring FGF2-Akt and BDNF-TrkB signaling axis to inhibit apoptosis

Zhong¹,

Wang²,

Gu³

et al. 2020

Int. J. Med. Sci.

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Ginsenoside Rg1 is the main active ingredient of Panax ginseng with the activity of neuroprotective, antioxidant and strengthening the immune system. Therefore, we hypothesized that Rg1 may afford anti-aging effects although the mechanism remains to be elucidated. In this study, chemically induced aging mice were established by consecutive administration of D-galactose and AlCl3. We found that Rg1 effectively ameliorates spatial learning and memory deficits in aging mice demonstrated by their improved performance in step down avoidance tests and Morris water maze experiments. Rg1 restored aging-induced decline of FGF2 and BDNF, reactivated TrkB/Akt signaling pathways in the hippocampus and prefrontal cortex to inhibit apoptosis, for the expression of anti-apoptotic protein Bcl-2 and apoptosis promoting enzyme cleaved-Caspase3 were antagonistically restored. Therefore, these results established the anti-aging effects of Rg1, and FGF2, BDNF and associated signaling pathways might be promising targets. Our data may provide a new avenue to the pharmacological research and diet therapeutic role of ethnic products such as Rg1 in anti-aging and aging associated diseases.

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“…Natural products possessing a high safety profile and tolerability may provide alternatives in the treatment of depression (Iovieno, Dalton, Fava, & Mischoulon, ; Liu et al, ; Sun et al, ). Ginseng is a traditional herbal product that has been used as an anticancer, antiaging, antifatigue, antioxidant, and neuroprotective agent since ancient times in many Asian and oriental countries.…”

Section: Introductionmentioning

confidence: 99%

Antidepressant effects of dammarane sapogenins in chronic unpredictable mild stress‐induced depressive mice

Jiang

Beiyue

Dong

et al. 2018

Phytotherapy Research

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Depression is a common, dysthymic, and psychiatric disorder, resulting in enormous social and economic burden. Dammarane sapogenins (DS), an active fraction from oriental ginseng, has shown antidepressant-like effects in chronic restraint rats and sleep interruption-induced mice, and the present study aimed to further confirm the antidepressant effects of DS in a model of chronic unpredictable mild stress (CUMS) and to explore the underlying mechanism. Oral administration of DS (20, 40, and 80 mg/kg) markedly improved depressant-like behaviors, increasing the sucrose intake in the sucrose preference test and reducing the latency in the novelty-suppressed feeding test, and decreasing the immobility time in both the tail suspension and forced swimming tests, compared with the CUMS mice. Biochemical analysis of brain tissue and serum showed that DS treatment restored the decreased hippocampal neurotransmitter concentrations of serotonin, dopamine, norepinephrine (noradrenaline), and gamma-aminobutyric acid, and decreased the elevated of serum hormone levels (corticotrophin releasing factor, adrenocorticotrophic hormone, and corticosterone) induced by CUMS. Our findings confirm that DS exerts an antidepressant-like effect in the CUMS model of depression in mice, and suggest it may be mediated by regulation of neurotransmitters and hypothalamic-pituitary-adrenal axis.

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The effects of ginsenoside Rg1 on chronic stress induced depression-like behaviors, BDNF expression and the phosphorylation of PKA and CREB in rats

Cited by 96 publications

References 40 publications

Ginsenoside Rg1 Prevents Chronic Stress-Induced Depression-Like Behaviors and Neuronal Structural Plasticity in Rats

Ginsenoside Rg1 Prevents Chronic Stress-Induced Depression-Like Behaviors and Neuronal Structural Plasticity in Rats

Ginsenoside Rg1 ameliorates the cognitive deficits in D-galactose and AlCl₃-induced aging mice by restoring FGF2-Akt and BDNF-TrkB signaling axis to inhibit apoptosis

Antidepressant effects of dammarane sapogenins in chronic unpredictable mild stress‐induced depressive mice

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The effects of ginsenoside Rg1 on chronic stress induced depression-like behaviors, BDNF expression and the phosphorylation of PKA and CREB in rats

Cited by 96 publications

References 40 publications

Ginsenoside Rg1 Prevents Chronic Stress-Induced Depression-Like Behaviors and Neuronal Structural Plasticity in Rats

Ginsenoside Rg1 Prevents Chronic Stress-Induced Depression-Like Behaviors and Neuronal Structural Plasticity in Rats

Ginsenoside Rg1 ameliorates the cognitive deficits in D-galactose and AlCl3-induced aging mice by restoring FGF2-Akt and BDNF-TrkB signaling axis to inhibit apoptosis

Antidepressant effects of dammarane sapogenins in chronic unpredictable mild stress‐induced depressive mice

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Product

Resources

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Ginsenoside Rg1 ameliorates the cognitive deficits in D-galactose and AlCl₃-induced aging mice by restoring FGF2-Akt and BDNF-TrkB signaling axis to inhibit apoptosis