The Effects of Gene Polymorphisms in Interleukin-4 and Interleukin-6 on the Susceptibility of Rheumatoid Arthritis in a Chinese Population

Li, Xiang; Chai, Wei; Ni, Ming; Xu, Meng; Lian, Zijian; Shi, Lewis L.; Bai, Yang; Wang, Yan

doi:10.1155/2014/265435

Cited by 20 publications

(28 citation statements)

References 38 publications

(49 reference statements)

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“…However, in Egyptian population, the C allele was associated with RA susceptibility . The same polymorphic variant was correlated with a significantly increased risk of RA in Chinese patients . Some potential associations were also suggested for Europeans …”

Section: Characteristics Of Ra Patientssupporting

confidence: 93%

Interleukin 6 gene polymorphism is associated with protein serum level and disease activity in Polish patients with rheumatoid arthritis

Wielińska

Dratwa

Świerkot

et al. 2018

HLA

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IL-6 is a pro-inflammatory cytokine involved in development of rheumatoid arthritis (RA). The present study aimed to determine the possible association of the IL6 (rs1800795, G>C) polymorphism with RA susceptibility, disease progression and protein serum levels. Distribution of IL6 alleles and genotypes was similar in RA patients and controls. As expected, patients before induction of anti-TNF agents had significantly higher IL-6 levels as compared to controls (p=0.002). The CC homozygous patients were characterized with the highest average concentrations of this pro-inflammatory cytokine before treatment (p=0.028) and they also more frequently presented with more active disease (p=0.048). These results imply that the IL6 rs1800795 CC homozygosity may play a rather unfavourable role in RA. This article is protected by copyright. All rights reserved.

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Section: Characteristics Of Ra Patientssupporting

confidence: 93%

Interleukin 6 gene polymorphism is associated with protein serum level and disease activity in Polish patients with rheumatoid arthritis

Wielińska

Dratwa

Świerkot

et al. 2018

HLA

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“…[ 19 , 35 , 39 – 41 ] The publication years ranged from 2000 to 2014, and the total sample size ranged from 32 [ 40 ] to 1550. [ 27 ]…”

Section: Resultsmentioning

confidence: 99%

Circulating interleukin-6 and rheumatoid arthritis

Xiao²,

Xing³

et al. 2016

Medicine

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Interleukin-6 (IL-6), as a pleiotropic cytokine, has been demonstrated to be closely associated with the pathogenisis of rheumatoid arthritis (RA). However, whether this association is causal or not remains unclear, because of the multifactorial role of IL-6 and related confounding factors. We aimed to evaluate the causal relevance between circulating IL-6 levels and the risk of RA through meta-analytical Mendelian randomization approach. IL-6 gene -174G/C variant was selected as an instrument in this Mendelian randomization meta-analysis. Article identification and data collection were conducted in duplicate and independently by 2 authors. The STATA software was used for data analysis. In total, 15 and 5 articles on the association of the -174G/C variant with RA risk and circulating IL-6 level, respectively, were included. The overall analysis showed that C allelic and GC+CC genotype were significantly with 1.59-fold (95% CI: 1.19–2.14) and 1.63-fold (95% CI: 1.17–2.26) increased risk of developing RA, respectively. Asian populations showed stronger association with 4.55-fold (95% CI: 1.62–12.75), 1.84-fold (95% CI: 1.13–2.99), and 4.69-fold (95% CI: 1.68–13.14) increased RA risk in carriers of -174C allelic, CC, and GC+CC genotype, respectively. Carriers of GC+CC genotype showed significant reduction in the circulating IL-6 level compared with GG carriers (WMD = −0.77; 95% CI: −1.16 to −0.38; P = 0.000) in overall populations. Mendelian randomization presented 6% and 22% increased risk of RA with 0.1 pg/mL reduction of circulating IL-6 level in overall and Asian populations, respectively. This Mendelian randomization meta-analysis demonstrated that the long-term genetically reduced circulating IL-6 level might be causally related to a higher risk of RA, especially in Asian populations.

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“…Their results also showed a significantly increased risk of RA for the CC genotype and the C allele of IL-6 −174G/C gene polymorphism in Chines population [16]. …”

Section: Discussionmentioning

confidence: 99%

Assessment of the âˆ’174G/C (rs1800795) and âˆ’572G/C (rs1800796) Interleukin 6 Gene Polymorphisms in Egyptian Patients with Rheumatoid Arthritis

Amr

El-Awady

Raslan

2016

Open Access Maced J Med Sci

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AIM:This study aimed to investigate genotype and allele frequencies of −174 (rs1800795) and −572 (rs1800796) IL-6 promoter gene polymorphisms in Egyptian patients with rheumatoid arthritis (RA) in comparison to control group.METHODS:The study was conducted on 198 Egyptian subjects (99 RA patients and 99 healthy control). The promoter region of the IL-6 gene was amplified by PCR using DNAs from patients and the controls, and their PCR products were digested by suitable enzymes.RESULTS:No statistical differences were found in −572G/C genotype (P = 0.177) or allele (P = 0.147) frequencies between RA patients and controls. Significant differences were observed in −174G/C genotype (P < 0.001) and allele (P < 0.001) frequencies between RA patients and controls.CONCLUSION:A significant association of IL-6 −174G/C gene polymorphism and RA in Egyptian population was found with significantly higher frequencies of GC and CC genotypes and C allele in RA patients compared to controls. No association was found between IL-6 −572G/C gene polymorphism and RA.

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The Effects of Gene Polymorphisms in Interleukin-4 and Interleukin-6 on the Susceptibility of Rheumatoid Arthritis in a Chinese Population

Cited by 20 publications

References 38 publications

Interleukin 6 gene polymorphism is associated with protein serum level and disease activity in Polish patients with rheumatoid arthritis

Interleukin 6 gene polymorphism is associated with protein serum level and disease activity in Polish patients with rheumatoid arthritis

Circulating interleukin-6 and rheumatoid arthritis

Assessment of the âˆ’174G/C (rs1800795) and âˆ’572G/C (rs1800796) Interleukin 6 Gene Polymorphisms in Egyptian Patients with Rheumatoid Arthritis

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