The Effects of GABA-Rich Adzuki Beans on Glycolipid Metabolism, as Well as Intestinal Flora, in Type 2 Diabetic Mice

Zhang, Aiwu; Jiang, Xiujie; Xu, Qingpeng; Li, Zhijiang; Tang, Huacheng; Cao, Dongmei; Dong-jie, Zhang

doi:10.3389/fnut.2022.849529

Cited by 12 publications

(17 citation statements)

References 28 publications

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“…Moreover, the decrease in the Firmicutes/Bacteroidetes ratio is correlated to weight loss, and the whole grain can improve this ratio (Martnez et al, 2013;Porras et al, 2017;Vacca et al, 2020). The Firmicutes/Bacteroidetes ratio decreased in mice fed a high-fat diet with sprouted adzuki beans, which was consistent with the results in this study (Figure 5E) (Zhang et al, 2022). At the microbiota family level, Lachnospiraceae is the core family of gut microbiota, whose metabolism has been demonstrated.…”

Section: Discussionsupporting

confidence: 89%

Comparative study of the effects of Tartary buckwheat seed and sprout consumption on the physiological indices and gut microbiota of C57BL/6J mice

Nan¹,

Zhao²,

Wu³

et al. 2024

Food Science and Human Wellness

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Tartary buckwheat (Fagopyrum Tataricum) is a well-known pseudocereal for its health and economic value. However, abundant antinutritional factors (ANFs) reduces its health benefits. As reported, germination can improve the nutritional profile of grains. In this study, we systematically evaluate the safety of Tartary buckwheat seeds (TB) and Tartary buckwheat sprouts (TBS) used as high active ingredients. After evaluating nutrition levels, bioactive compounds and ANFs in TBS during germinating, fifth-day TBS were selected as the raw material. C57BL/6J mice were gavaged daily with distilled water, TB, or TBS for 6 weeks. The physiological indices related to ANFs were determined. Results showed that the TB intake tends to generate negative effects on the gut microbiota, and organs. Additionally, upon TB intake, the Fe 3+ content in serum, trypsin activity in pancreas and jejunum decreased, while the cytokine, IgE, and histamine levels in serum, water content in faeces, cytokine levels in liver and jejunum increased. Conversely, TBS did not induce any obvious negative effects on the above relevant indices and showed better lipid-lowering effect. Altogether, TBS are safer and more effective as a raw material to produce the functional food for long-term consumption with the intention of preventing and treating hyperlipidaemia.

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Section: Discussionsupporting

confidence: 89%

Comparative study of the effects of Tartary buckwheat seed and sprout consumption on the physiological indices and gut microbiota of C57BL/6J mice

Nan¹,

Zhao²,

Wu³

et al. 2024

Food Science and Human Wellness

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show abstract

“…As described above, the gut microbiota is an important player in the physiology and pathology of DM. Therefore, many animal and clinical experiments are conducted to explore preventive and therapeutic strategies for DM that target the gut microbiota. − Meaningfully, some foods and herbal medicines have been shown to have beneficial uses for different types of DM. − They contain abundant natural products and exert antidiabetic effects by improving the intestinal microecological environment (Figure ).…”

Section: Natural Products Targeting the Gut Microbiota In Dmmentioning

confidence: 99%

Preclinical Studies of Natural Products Targeting the Gut Microbiota: Beneficial Effects on Diabetes

Jiang

Sun

Zhou

2022

J. Agric. Food Chem.

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Diabetes mellitus (DM) is a serious metabolic disease characterized by persistent hyperglycemia, with a continuously increasing morbidity and mortality. Although traditional treatments including insulin and oral hypoglycemic drugs maintain blood glucose levels within the normal range to a certain extent, there is an urgent need to develop new drugs that can effectively improve glucose metabolism and diabetes-related complications. Notably, accumulated evidence implicates that the gut microbiota is unbalanced in DM individuals and is involved in the physiological and pathological processes of this metabolic disease. In this review, we introduce the molecular mechanisms by which the gut microbiota contributes to the development of DM. Furthermore, we summarize the preclinical studies of bioactive natural products that exert antidiabetic effects by modulating the gut microbiota, aiming to expand the novel therapeutic strategies for DM prevention and management.

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“…In addition to anthocyanins, phenolic compounds and saponin components of adzuki beans collectively contribute to their health-promoting and disease deterrence properties and are receiving much attention in recent years [ 31 , 32 , 47 , 48 ]. In addition, the abundance of phenolic compounds could improve the quality and shelf life of other food products and hence, promote the use of adzuki bean seeds as natural antioxidants [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

Variability of Anthocyanin Concentrations, Total Metabolite Contents and Antioxidant Activities in Adzuki Bean Cultivars

et al. 2022

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In this study, adzuki bean cultivars including Arari, Chilbopat, Geomguseul, and Hongeon were recently cultivated, and the concentrations of seven individual anthocyanins were determined in their seed coats for the first time. Moreover, the variations of total saponin content (TSC), total phenolic content (TPC), 1,1-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, Trolox equivalent antioxidant capacity (TEAC), and ferric reducing antioxidant power (FRAP) between defatted and undefatted extracts of whole seeds, seed coats, and dehulled seeds of each were analyzed. The anthocyanins were detected only in the black seed-coated cultivars and delphinidin-3-O-glucoside was dominant in both Geomguseul (12.46 mg/g) and Chilbopat (10.88 mg/g) followed by delphinidin-3-O-galactoside. TSC and TPC were in the ranges of 16.20–944.78 mg DE/g and 0.80–57.35 mg GAE/g, respectively, and each decreased in the order of seed coats > whole seeds > dehulled seeds regardless of extract type. The antioxidant activities also showed similar patterns of variation. Geomguseul seed coats outweighed the remaining cultivars in terms of TPC and FRAP activity (p < 0.05). Generally, significant variations of metabolite contents and antioxidant activities were observed between cultivars and across their seed parts (p < 0.05). Thence, black seed-coated adzuki beans could be excellent sources of anthocyanins and antioxidants.

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The Effects of GABA-Rich Adzuki Beans on Glycolipid Metabolism, as Well as Intestinal Flora, in Type 2 Diabetic Mice

Cited by 12 publications

References 28 publications

Comparative study of the effects of Tartary buckwheat seed and sprout consumption on the physiological indices and gut microbiota of C57BL/6J mice

Comparative study of the effects of Tartary buckwheat seed and sprout consumption on the physiological indices and gut microbiota of C57BL/6J mice

Preclinical Studies of Natural Products Targeting the Gut Microbiota: Beneficial Effects on Diabetes

Variability of Anthocyanin Concentrations, Total Metabolite Contents and Antioxidant Activities in Adzuki Bean Cultivars

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