The effects of fructose-1,6-diphosphate on haemodynamic parameters and survival in a rodent model of propranolol and verapamil poisoning

Kalam, Yasmean; Graudins, Andis

doi:10.3109/15563650.2012.705847

Cited by 7 publications

(5 citation statements)

References 23 publications

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“… 138–140 Animal studies showed conflicting results for the use of carnitine. 153–155 Finally, only animal studies were found for the following interventions: Bay K 8644 and CGP 28932, 100 , 101 , 103 digoxin, 141–143 cyclodextrin, 144 , 145 suggamadex, 146 liposomes, 147 , 148 bicarbonate, 149 fructose 1,6-diphosphate, 150 PK11195 151 and triiodothyronine. 152 …”

Section: Resultsmentioning

confidence: 99%

Treatment for calcium channel blocker poisoning: A systematic review

St‐Onge

Dubé

Gosselin

et al. 2014

Clinical Toxicology

155

135

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ContextCalcium channel blocker poisoning is a common and sometimes life-threatening ingestion.ObjectiveTo evaluate the reported effects of treatments for calcium channel blocker poisoning. The primary outcomes of interest were mortality and hemodynamic parameters. The secondary outcomes included length of stay in hospital, length of stay in intensive care unit, duration of vasopressor use, functional outcomes, and serum calcium channel blocker concentrations.MethodsMedline/Ovid, PubMed, EMBASE, Cochrane Library, TOXLINE, International pharmaceutical abstracts, Google Scholar, and the gray literature up to December 31, 2013 were searched without time restriction to identify all types of studies that examined effects of various treatments for calcium channel blocker poisoning for the outcomes of interest. The search strategy included the following Keywords: [calcium channel blockers OR calcium channel antagonist OR calcium channel blocking agent OR (amlodipine or bencyclane or bepridil or cinnarizine or felodipine or fendiline or flunarizine or gallopamil or isradipine or lidoflazine or mibefradil or nicardipine or nifedipine or nimodipine or nisoldipine or nitrendipine or prenylamine or verapamil or diltiazem)] AND [overdose OR medication errors OR poisoning OR intoxication OR toxicity OR adverse effect]. Two reviewers independently selected studies and a group of reviewers abstracted all relevant data using a pilot-tested form. A second group analyzed the risk of bias and overall quality using the STROBE (STrengthening the Reporting of OBservational studies in Epidemiology) checklist and the Thomas tool for observational studies, the Institute of Health Economics tool for Quality of Case Series, the ARRIVE (Animal Research: Reporting In Vivo Experiments) guidelines, and the modified NRCNA (National Research Council for the National Academies) list for animal studies. Qualitative synthesis was used to summarize the evidence. Of 15,577 citations identified in the initial search, 216 were selected for analysis, including 117 case reports. The kappa on the quality analysis tools was greater than 0.80 for all study types.ResultsThe only observational study in humans examined high-dose insulin and extracorporeal life support. The risk of bias across studies was high for all interventions and moderate to high for extracorporeal life support. High-dose insulin. High-dose insulin (bolus of 1 unit/kg followed by an infusion of 0.5–2.0 units/kg/h) was associated with improved hemodynamic parameters and lower mortality, at the risks of hypoglycemia and hypokalemia (low quality of evidence). Extracorporeal life support. Extracorporeal life support was associated with improved survival in patients with severe shock or cardiac arrest at the cost of limb ischemia, thrombosis, and bleeding (low quality of evidence). Calcium, dopamine, and norepinephrine. These agents improved hemodynamic parameters and survival without documented severe side effects (very low quality of evidence). 4-Aminopyridine. Use of 4-aminopyridine was assoc...

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Section: Resultsmentioning

confidence: 99%

Treatment for calcium channel blocker poisoning: A systematic review

St‐Onge

Dubé

Gosselin

et al. 2014

Clinical Toxicology

155

135

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“…F6P is an important phosphorylated carbohydrate involved in the non-oxidative pentose phosphate pathway and is of particular interest for the study of various metabolic diseases. F6P is also an important precursor for the production of d -fructose-1,6-diphosphate and various other phosphate sugars with important therapeutic values for the treatment of sickle cell anemia, congestive heart failure, myocardial infarction, and neurodegenerative disease [ 14 , 15 ]. To obtain F6P in a sufficiently large quantity, a less expensive high-yield production method must be developed.…”

Section: Resultsmentioning

confidence: 99%

“…F6P is also an important precursor for the production of d -fructose-1,6-diphosphate via phosphofructokinase 1 catalysis [ 13 ]. d -fructose-1,6-diphosphate has proven therapeutic potential; clinical data show that this carbohydrate may be useful in a variety of ischaemic conditions, reduction of ischaemic injury in sickle cell anemia, congestive heart failure, bypass surgery, myocardial infarction, and organ preservation for transplantation [ 14 , 15 ]. Other important molecules such as glyceraldehyde-3-phosphate and dihydroxyacetone phosphate have medicinal value (candidate drugs for the treatment of degenerative diseases) and can be obtained in a cascade reaction from fructose-1,6-diphosphate with the help of fructose 1,6-bisphosphate aldolase [ 12 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Characterization of a Mannose-6-Phosphate Isomerase from Bacillus amyloliquefaciens and Its Application in Fructose-6-Phosphate Production

Sigdel¹,

Singh²,

Kim³

et al. 2015

PLoS ONE

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The BaM6PI gene encoding a mannose-6-phosphate isomerase (M6PI, EC 5.3.1.8) was cloned from Bacillus amyloliquefaciens DSM7 and overexpressed in Escherichia coli. The enzyme activity of BaM6PI was optimal at pH and temperature of 7.5 and 70°C, respectively, with a kcat/Km of 13,900 s-1 mM-1 for mannose-6-phosphate (M6P). The purified BaM6PI demonstrated the highest catalytic efficiency of all characterized M6PIs. Although M6PIs have been characterized from several other sources, BaM6PI is distinguished from other M6PIs by its wide pH range and high catalytic efficiency for M6P. The binding orientation of the substrate M6P in the active site of BaM6PI shed light on the molecular basis of its unusually high activity. BaM6PI showed 97% substrate conversion from M6P to fructose-6-phosphate demonstrating the potential for using BaM6PI in industrial applications.

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“…It increases the production of ATP in conditions where phosphofructokinase is inhibited (e. g. by lactate) and preserves its own macroergic cell phosphates for pre-phosphorylation of hexoses. The relative ATP production by anaerobic glycolysis is greater for FDP than glucose [29,30].…”

Section: Discussionmentioning

confidence: 96%

“…Analyzing the clinical effects of FDP, several authors noted that it may restore inhibited glycolytic activity in the ischemic myocardium by regulating the effect on the glycolytic pathway, and also be a substrate for this pathway. Other researchers have shown that FDP reduces the area of tissue ischemia in experimental cerebral and myocardial infarction and improves hemodynamics after cardiac bypass [30]. Some data have demonstrated the absence of hypotensive effect of FDP that allows using it in patients with shock conditions and unstable hemodynamics [15].…”

Section: Discussionmentioning

confidence: 99%

Indicators of cellular metabolism alterationsin patients with traumatic disease due to hypoxia, depending on a management regimen of intensive care

Matvieienko

Belozorov

Shamoun

et al. 2021

ZMJ

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The aim of this study was to evaluate changes in the level of erythrocyte metabolism under conditions of hypoxia in patients with traumatic disease in polytrauma depending on the components of intensive care (IC). Materials and methods. A prospective study was carried out in 88 patients suffering from polytrauma in the period from 2015 to 2017. All the patients were divided into 2 groups, comparable by severity of trauma and condition. A special feature of the examined patients was the staged surgical correction in all cases according to the Damage Control concept. Patients from the Control group received an intensive care according to the standard local clinical protocol in polytrauma. Patients randomized to the FDP group were treated with infusion of D-fructose-1,6-diphosphate sodium hydrate in addition to the standard care. Hemodynamic parameters and cellular metabolism indicators were monitored: on admission to the operating room, after 24 hours, on day 3, 5 and 14. Results. The signs of hypovolemia were equally severe in both groups on admission to the operating room. The FDP group demonstrated more rapid stabilization of hemodynamics and improved myocardial contractility at the 3rd day of IC. The monitoring of acid-base balance and carbohydrate metabolism showed the presence of compensated metabolic acidosis and energy deficiency. High indexes of lactate/pyruvate indicated a sharp imbalance in the ratio of aerobic/anaerobic metabolic processes. The analysis of ATP dynamics displayed impaired mitochondrial ATP production and inhibition of the glycolytic pathway of energy release. Conclusions. Complementary systemic inflammatory response with the elevation of lactate level by the 5th day occurred in patients with traumatic disease who underwent staged surgical correction. Optimization of intensive care resulted in a faster restoration of the balance between aerobic and anaerobic metabolic processes, an increase in the level of ATP and the rate of 2,3-DPG production in erythrocytes contributing to adequate oxygen supply to the tissues, supporting cellular respiration and preventing the development of oxidative tissue damage, as well as helped to maintain compensatory mechanisms and reduce cellular hypoxia ensuring adequate metabolism of vital organs.

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The effects of fructose-1,6-diphosphate on haemodynamic parameters and survival in a rodent model of propranolol and verapamil poisoning

Cited by 7 publications

References 23 publications

Treatment for calcium channel blocker poisoning: A systematic review

Treatment for calcium channel blocker poisoning: A systematic review

Characterization of a Mannose-6-Phosphate Isomerase from Bacillus amyloliquefaciens and Its Application in Fructose-6-Phosphate Production

Indicators of cellular metabolism alterationsin patients with traumatic disease due to hypoxia, depending on a management regimen of intensive care

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