The effects of folate supplementation on inflammatory factors and biomarkers of oxidative stress in overweight and obese women with polycystic ovary syndrome: a randomized, double‐blind, placebo‐controlled clinical trial

Abstract

In conclusion, folate supplementation (5 mg/d) in women with PCOS had beneficial effects on inflammatory factors and biomarkers of oxidative stress.

The Effects of Folate Supplementation on Carotid Intima-Media Thickness and Metabolic Status in Patients with Metabolic Syndrome

“…In agreement with our findings, a significant reduction in CRP concentrations was seen following the administration of B-group vitamins (5 mg folic acid, 5 mg vitamin B2, 50 mg vitamin B6, and 0.4 mg vitamin B12) among patients with acute ischemic stroke for 14 days [38]. Our previous study among PCOS women reinforced that taking 5 mg/day folate supplements for 8 weeks resulted in a significant decrease in serum hs-CRP, MDA and a significant rise in plasma TAC and GSH, but did not affect plasma NO levels [12]. In addition, low-dose folic acid (400 µg/day) treatment among patients with CAD for 7 weeks, comparable to daily intake and dietary fortification, improved vascular function through effects on endothelial NO synthase and vascular oxidative stress [39].…”

“…A similar observation was made among studies with baseline levels of higher CIMT or a larger Hcy reduction. In addition, our previous study among patients with polycystic ovary syndrome (PCOS) demonstrated that folate supplementation (5 mg/day) for 8 weeks had beneficial effects on insulin resistance, inflammatory factors and biomarkers of oxidative stress [12]. Despite a considerable increase in folate concentrations by ≈570% and a reduction in Hcy concentrations by ≈25%, 3-year folic acid (800 μg/day) supplementation did not slow down atherosclerotic progression or arterial stiffening in older adults [13].…”

Potential benefits of adlay on hyperandrogenism in human chorionic gonadotropin-treated theca cells and a rodent model of polycystic ovary syndrome

“…Clinically, PCOS patients typically exhibit IR (Niu, Lin, Gu, Sun, & Feng, 2014), increased oxidative stress (Boutzios et al, 2013), and inflammatory responses (Bahmani, Karamali, Shakeri, & Asemi, 2014). Here, PCOS rats with DHEA-induced hyperandrogenemia exhibited significantly elevated blood sugar homeostasis parameters, ovarian oxidative stress indicators, and inflammatory response indicators relative to the vehicle group.…”

Effective treatment of skin and metabolic manifestations of hyperandrogenism: a comprehensive improvement of quality of life

“…Incidence of acne, hirsutism, seborrhea, androgenic alopecia and acanthosis nigricans in patients with PCOS [1] может быть независимым фактором риска возникновения акне. Эти результаты являются весомым аргументом в пользу применения для лечения акне комбинации 20 мкг ЭЭ/3 мг ДРСП с добавлением левомефолата кальция (Джес ® Плюс), поскольку доказано, что фолаты способствуют снижению уровня гомоцистеина [16]. Кроме того, было выявлено, что пациенты с акне имеют более высокие уровни инсулиноподобного фактора роста-I (ИПФР-I), способствующего прогрессированию акне вне зависимости от тяжести заболевания [17], а потребление фолатов в адекватных дозах статистически значимо снижает уровень ИПФР-I [18].…”