Potential benefits of adlay on hyperandrogenism in human chorionic gonadotropin-treated theca cells and a rodent model of polycystic ovary syndrome

Wu, Chi Hao; Chen, Mei-Jou; Shieh, Tzong‐Ming; Wang, Kai-Lee; Wu, Ya; Hsia, Shih Min; Chiang, Wenchang

doi:10.1016/j.jff.2014.10.003

Cited by 7 publications

(4 citation statements)

References 48 publications

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“…Traditionally, Coix lacryma-jobi seeds have been utilized as herbal medicine for the treatment of diabetes, asthma, inflammation, cough, diarrhea (Choi et al, 2015), pulmonary edema, wet pleurisy, chronic ulcer, dysuria (Feng et al, 2020), rheumatism, osteoporosis, ) chronic gastrointestinal disease (Choi et al, 2015;Feng et al, 2020), and as a diuretic , Zhu, 2017Wu et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Hence, it paved way for the occurrence of integration of traditional and modern medicine (Kuo, 2012) which was also evident from the different bioinformatics tools. Traditionally , Coix lacryma-jobi seeds have been utilized as herbal medicine for the treatment of diabetes, asthma, inflammation, cough, diarrhea (Choi et al, 2015), pulmonary edema, wet pleurisy, chronic ulcer, dysuria (Feng et al, 2020), rheumatism, osteoporosis, (Zhang et al, 2019) chronic gastrointestinal disease (Choi et al, 2015; Feng et al, 2020), and as a diuretic (Zhang et al, 2019, Zhu, 2017; Wu et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

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Pharmacological mechanisms on the anti-breast cancer property of Coix lacryma-jobi: A network-based analysis

Ferrer

David

Taquiqui

et al. 2021

Preprint

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Breast cancer is considered as one of the three most common cancers around the world and the second leading cause of cancer deaths among women. Coix lachrymal jobi, commonly known as Jobs tears or adlay has been reported to possess anti-cancer properties. Despite evidences provided by clinical data, the usage of Coix lacryma-jobi in treating cancer, particularly breast cancer, has been scarce. Thus, this study was conducted to determine the pharmacological mechanisms underlying its anti-breast cancer property using various network pathway analyses. Bioactive compounds from Coix lacryma-jobi and its potential target genes were obtained from SymMap. Breast cancer-related target genes were collected from CTD. Protein-protein interaction network was analyzed using the STRING database. GO and KEGG pathway enrichment analyses were performed using DAVID to further explore the mechanisms of Coix lacryma-jobi in treating breast cancer. PPI and compound-target-pathway were visualized using Cytoscape. A total of 26 bioactive compounds, 201 corresponding targets, 36625 breast cancer-associated targets were obtained, and 200 common targets were considered potential therapeutic targets. The 9 bioactive compounds identified were berberine, oleic acid, beta-sitosterol, sitosterol, linoleic acid, berberrubine, jatrorrhizine, thalifendine, and stigmasterol. The identified 5 core targets were ESR1, JUN, MAPK14, and RXRA. Coix lacryma-jobi targets enriched in GO terms were mostly involved in regulation of transcription from RNA polymerase II promoter, drug response, steroid hormone receptor activity, and protein binding. This study elucidates on the pharmacological underpinnings on the potency of adlay against breast cancer. Its subsequent drug development will be worth a step forward for a breast cancer-free society.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pharmacological mechanisms on the anti-breast cancer property of Coix lacryma-jobi: A network-based analysis

Ferrer

David

Taquiqui

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Hence, it paved way for the occurrence of integration of traditional and modern medicine (Kuo, 2012) which was also evident from the different bioinformatics tools. Traditionally, adlay seed has been utilized as herbal medicine for the treatment of diabetes, asthma, inflammation, cough, diarrhea (Choi et al, 2015), pulmonary edema, wet pleurisy, chronic ulcer, dysuria (Feng et al, 2020), rheumatism, osteoporosis, ) chronic gastrointestinal disease (Choi et al, 2015;Feng et al, 2020), and as a diuretic , Zhu, 2017Wu et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Network-based analysis on pharmacological mechanisms underlying the anti-diabetic property of Coix lacryma-jobi

Tanquiqui

Ferrer

David

et al. 2021

Preprint

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Diabetes mellitus (DM) is the most common endocrine disorder and among the top 10 leading diseases causing death worldwide. Coicis semen [CS] (Coix lachryma-jobi L.), also known as adlay have been reported to display anti-diabetic properties. Unfortunately, studies on the pharmacological mechanisms involving adlay for the treatment of diabetes are nil. Thus, this study was conducted to evaluate the interactions and mechanisms of the bioactive compound targets of adlay in the treatment of diabetes using network analysis. Adlay bioactive compounds and potential target genes were obtained from SymMap. Diabetes related target genes were collected from CTD. Protein-Protein Interaction Network was analyzed using the STRING database. GO and KEGG pathway enrichment analyses were performed using DAVID to further explore the mechanisms of adlay in treating diabetes. PPI and compound-target-pathway were visualized using Cytoscape. A total of 25 bioactive compounds, 201 corresponding targets, and 35839 diabetes mellitus associated targets were obtained while 200 were considered potential therapeutic targets. The 9 bioactive compounds studied were berberine, oleic acid, beta-sitosterol, sitosterol, linoleic acid, berberrubine, jatrorrhizine, thalifendine, and stigmasterol. The identified 5 core targets were ESR1, JUN, MAPK14, and RXRA. Adlai targets enriched in GO terms were mostly involved with positive regulation of transcription, response to drugs, and negative regulation of apoptosis. This study provides novel research insights into the clinical properties of adlay in diabetes melitus treatment.

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“…In women’s health, two phytosterols, stigmasterol and β-sitosterol, from the ethyl acetate fraction of adlay hull reduced uterine myometrial hyperplasia induced in a mouse model [ 18 ]. Additionally, four major flavonoids constituents from adlay hull ethanolic extract exhibited inhibition on polycystic ovary syndrome (PCOS) [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Adlay Testa (Coix lachryma-jobi L. var. Ma-yuen Stapf.) Ethanolic Extract and Its Active Components Exert Anti-Proliferative Effects on Endometrial Cancer Cells via Cell Cycle Arrest

et al. 2021

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Endometrial cancer is the most common malignant tumors of gynecologic neoplasms in Western society. In recent years, the incidence of endometrial cancer has increased, and it has become the third most common female gynecological cancer (after ovarian and cervical cancer) in Taiwan. Adlay (Coix lachryma-jobi L. var. Ma-yuen Stapf.) has been demonstrated to have bioactive polyphenols, flavonoids, phytosterols, and essential nutrients for health benefits, including anticancer effects in humans. However, little is known about the effect of adlay seeds on endometrial cancer. Our study aimed to investigate the potential growth inhibitory effects of several adlay seed fractions, including ethyl acetate (ATE-EA) and its bioactive constituents, separately on endometrial cancer cells—HEC-1A (phosphatase and tensin homolog-positive) and RL95-2 (phosphatase and tensin homolog-negative)—and identify related active ingredients. In addition, the potential active fractions and the phytochemical compounds were elucidated. The results demonstrate superior activity of ATE-EA with significant in vitro cell proliferation inhibitory capacity, particularly its C.D.E.F-subfraction. Moreover, HPLC- and GC/FID-based quantification of ATE-EA subfractions showed that phenolic compounds (caffeic acid, protocatechuic acid, and p-hydroxybenzaldehyde), flavonoids, steroids, and fatty acid compounds exert anti-proliferative effects in the cell model. Finally, it was shown that cell growth and cell cycle arrest most significantly occurred in the in G1 or G2/M phase under ATE-EA treatment. Collectively, our results demonstrate an antiproliferative effect of ATE-EA on endometrial cancer cells that suggest a positive health outcome for women from consumption of these compounds.

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Potential benefits of adlay on hyperandrogenism in human chorionic gonadotropin-treated theca cells and a rodent model of polycystic ovary syndrome

Cited by 7 publications

References 48 publications

Pharmacological mechanisms on the anti-breast cancer property of Coix lacryma-jobi: A network-based analysis

Pharmacological mechanisms on the anti-breast cancer property of Coix lacryma-jobi: A network-based analysis

Network-based analysis on pharmacological mechanisms underlying the anti-diabetic property of Coix lacryma-jobi

Adlay Testa (Coix lachryma-jobi L. var. Ma-yuen Stapf.) Ethanolic Extract and Its Active Components Exert Anti-Proliferative Effects on Endometrial Cancer Cells via Cell Cycle Arrest

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