The effects of extract andaliman fruit (Zanthoxylum acanthopodium Dc) to CAMP mRNA expression and bacterial load in mice balb-C after Gardnerella vaginal Infection

Sirait, Lenny Irmawaty; Massi, Maurizio; Hatta, Mochammad; Prihantono, Prihantono

doi:10.5958/0976-5506.2018.01525.5

Cited by 8 publications

(2 citation statements)

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“…Several herbal products can be used as therapy for infectious and non-infectious diseases, like Curcuma xanthorriza Sygium aromaticum 3 , Musa L.paradisiaca L (MPL) 4 , Red fruit (Pandanus conoideus) 5 , Curcuma longa 6 , Miana Leaves (Coleus scutellariodes (L) 7 , Andaliman (Zantoxylum acanthopodium DC) 8 , Curcumin 9 , Sapodilla fruit 10 , Ajwa dates 11 and Thallasia hemprichi grass 12 .…”

Section: Introductionmentioning

confidence: 99%

The Chemical Composition of Trigona Honey in Bone, South Sulawesi

2020

IJPHRD

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Introduction Trigona honey (Tetragonula biroi) is a type of honey produced by stingless bees that is one of the local products in South Sulawesi with the Tetragonula species widely known to the public. Objective This study was to determine the nutritional content of trigona honey and components of its secondary metabolite compounds as herbal therapy for the disease. Method This study aims to analyze the content of bioactive compounds of trigona honey is using phytochemical test and proximate test method. Result Phytochemical test show trigona honey had bioactive compounds flavonoid, alkaloid and triterpenoid. Proximate test using thin-layer chromatography (TLC) showed that methanol extract of honey trigona (tetragonula biroi) contains vitamin C 0.15%, flavonoids 159.62 ppm, polyphenols 133.52 ppm, and there are magnesium, calcium, zinc and beta carotene. Conclusion Trigona honey contains metabolite compounds such as polyphenols, flavonoids, alkaloids, and triterpenoids.

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Section: Introductionmentioning

confidence: 99%

The Chemical Composition of Trigona Honey in Bone, South Sulawesi

2020

IJPHRD

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“…Numerous studies have examined the use and effects of traditional medicines for various diseases [ [1] , [2] , [3] , [4] , [5] ], including the effects of herbal medicines on infectious diseases, such as candidiasis [ [6] , [7] , [8] ], typhoid fever [ [9] , [10] , [11] , [12] , [13] , [14] ], toxoplasmosis [ [15] , [16] , [17] ], gingivitis [ 18 , 19 ], vaginitis [ 20 ], and the human immunodeficiency virus (HIV) [ 21 , 22 ], and noninfectious diseases such as diabetes [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

In vivo and in vitro inhibition effect of propolis on Klebsiella pneumoniae : A review

Taufik¹,

Natzir²,

Patellongi³

et al. 2022

Annals of Medicine &Amp; Surgery

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Increasing Natural Resistance Associated Macrophage Protein 1 serum level after Miana treatment in BALB/c induced Klebsiella pneumoniae experimental research

Wahyuni

Hatta

Bukhari

et al. 2021

Annals of Medicine &Amp; Surgery

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Background Miana ( Coleus Scutellariodes [L] Benth) inhibits growth of bacterial pathogen inside macrophage. Objective The aim of this study is to determine the protein level of Natural Resistance Associated Macrophage Protein 1 (NRAMP1), after administration of Miana extracts in BALB/c mice induced Klebsiella pneumoniae . Methods This is an experimental study using animal model with post test-only controlled group design. Twenty healthy adult male BALB/c mice were randomly divided into four groups, negative control group (distilled water), Levofloxacin 100 mg/kg, injection intraperitoneal, first treatment group (Miana leaves extract/MLE 510 mg/kg) and second treatment group (Miana + levofloxacin). MLE were administered via gastric gavage for ten consecutive days. The blood was drawn from each mice on the first day, on the eight day of experiment (2 h after treatment), and at 10 days. The blood sample was examined by ELISA to determine the NRAMP1 protein level. Analysis of the number of lung tissue bacteria used Plate count agar to see the growth of Klebsiella pneumonia . Results NRAMP1 protein level in BALB/c mice after administration of Miana extract was increased significantly in after 10 days treatment (p < 0.0001). The highest increasing in protein levels was found in treatment group (Miana + levofloxacin) with an increase before treatment 3036,07 to 10010,30 pg/ml after treatment p < 0,0001. Conclusion NRAMP1 protein level in BALB/c mice were highest increasing in protein levels after administration of Miana extract and Levofloxacin compared Miana or Levofloxacin only and clinical impact proved a comparable effect on suppressing Klebsiella pneumoniae growth. The institutional protocol number of this study is 1010/UN4.6.4.5.31/PP36/2019.

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The effects of extract andaliman fruit (Zanthoxylum acanthopodium Dc) to CAMP mRNA expression and bacterial load in mice balb-C after Gardnerella vaginal Infection

Cited by 8 publications

References 0 publications

The Chemical Composition of Trigona Honey in Bone, South Sulawesi

The Chemical Composition of Trigona Honey in Bone, South Sulawesi

In vivo and in vitro inhibition effect of propolis on Klebsiella pneumoniae : A review

Increasing Natural Resistance Associated Macrophage Protein 1 serum level after Miana treatment in BALB/c induced Klebsiella pneumoniae experimental research

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