The Effects of Exogenous Melatonin on Peripheral Nerve Regeneration and Collagen Formation in Rats

Atik, Bekir; Erkutlu, İbrahim; Tercan, Mustafa; Büyükhatipoğlu, Hakan; Bekerecioğlu, Mehmet; Pençe, Sadrettin

doi:10.1016/j.jss.2009.06.002

Cited by 48 publications

(50 citation statements)

References 22 publications

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“…15,27 Using an experimental PNI model, Atik et al suggested that the powerful antioxidant and cell-protective effects of MLT could result from mimicking calcium channel blockers. 28 It is therefore believed that boosting peripheral nerve repair with MLT could be a worthwhile option, in addition to other treatment modalities, in cases of MLT deficiency.…”

Section: Free Radical Scavenging Effects Of Melatonin In Peripheral Nmentioning

confidence: 99%

Untitled

2017

J Brachial Plex Peripher Nerve Inj

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Section: Free Radical Scavenging Effects Of Melatonin In Peripheral Nmentioning

confidence: 99%

Untitled

2017

J Brachial Plex Peripher Nerve Inj

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“…However, these antioxidant effects require concentrations of melatonin that are much higher than peak nighttime serum concentrations [5]. Damage of the peripheral nerve also causes the production of free oxygen radicals [2]. When damage occurs to a peripheral nerve, both ischaemic and inflammatory processes begin.…”

Section: Physiologic Effects Of Melatoninmentioning

confidence: 99%

“…When damage occurs to a peripheral nerve, both ischaemic and inflammatory processes begin. As a consequence of this process, free oxygen radicals and many toxic agents accumulate around the site of injury [2].…”

Section: Physiologic Effects Of Melatoninmentioning

confidence: 99%

“…Melatonin has many different roles in the human body, including its importance in circadian rhythms, sleep physiology, mental status, reproduction, tumour development, ageing, and many other physiologic processes [2]. Besides its well-known regulatory role on circadian rhythm, melatonin has other biological functions and a distinct metabolism in various cell types and peripheral tissues [28].…”

Section: Physiologic Effects Of Melatoninmentioning

confidence: 99%

“…In human studies, delivered doses of melatonin varied in a very large range, from 0.1 mg to 2000 mg [2]. After intravenous administration melatonin is rapidly distributed and eliminated [20], while bioavailability of orally administered melatonin varies widely [5].…”

Section: Therapeutic Dose Of Melatoninmentioning

confidence: 99%

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Melatonin and its therapeutic actions on peripheral nerve regeneration

Kandemir

Sarıkcıoğlu

2015

Folia Morphol

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The effect of melatonin and platelet gel on sciatic nerve repair: An electrophysiological and stereological study

et al. 2011

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Nerve regeneration after surgical reconstruction is far from optimal, and thus effective strategies for improving the outcome of nerve repair are being sought. In this experiment, we verified if postoperative intraperitoneal melatonin (MLT) administration after intraoperative platelet gel application improves peripheral nerve regeneration. In adult male rats, 1-cm long sciatic nerve defects were repaired using four different strategies: autologous nerve graft repair followed by MLT (NM, n = 5), collagen conduit repair followed by MLT (CM, n = 5), platelet gel-enriched collagen conduit repair followed by MLT (CGM, n = 6), and platelet gel-enriched collagen conduit (CG, n = 5) repair followed by no substance administration. Sham operated animals were used as controls (Cont, n = 5). Ninety days after surgery, the nerve regeneration outcome was comparatively assessed by means of electrophysiological and stereological analysis. Electrophysiology revealed no significant differences between the experimental and the sham control groups. Stereological analysis showed no significant differences among the experimental groups regarding axon size and myelin thickness, but the axon number was significantly lower in the CM compared to Cont and NM group. Moreover, there was no significant difference between number of axons in CG and Cont groups, between CGM and CM, and between CM and NM. Although it was observed that platelet gel have a positive effect on nerve regeneration, but a combination of local platelet gel with MLT does not have the same effect on nerve repair.

show abstract

The Effects of Exogenous Melatonin on Peripheral Nerve Regeneration and Collagen Formation in Rats

Cited by 48 publications

References 22 publications

Untitled

Untitled

Melatonin and its therapeutic actions on peripheral nerve regeneration

The effect of melatonin and platelet gel on sciatic nerve repair: An electrophysiological and stereological study

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