1946
DOI: 10.1002/ar.1090940307
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The effects of exercise on the knee‐joints of inbred mice

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Cited by 33 publications
(15 citation statements)
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“…1980] give rise to alterations of the articular cartilage. However, it is also evident that longterm training of experimental animals does not unavoidably lead to de generative changes of the articular cartilage [Lanier, 1946;Sciaf, 1950],…”
Section: Introductionmentioning
confidence: 99%
“…1980] give rise to alterations of the articular cartilage. However, it is also evident that longterm training of experimental animals does not unavoidably lead to de generative changes of the articular cartilage [Lanier, 1946;Sciaf, 1950],…”
Section: Introductionmentioning
confidence: 99%
“…It is possible that the differences in the incidence of osteoarthrosis in different strains of mice (58) might be attributable to the genetically deter mined rate of aging of the cartilage. In the mouse, at least, mechanical factors play a subordinate role in the pathogenesis of osteoarthrosis since in mice of strain D increased use of the knee joints had no effect on the frequency or severity of articular degeneration (24). Moreover, the different location of de generative changes within the knee joint in a number of murine strains could not be explained in terms of mechanical factors (57).…”
Section: Discussionmentioning
confidence: 99%
“…However, function preserves rather than injures cartilage and minimal trauma would hardly affect intact articulations: on the other hand, joint disease resulting from severe trauma would have to be classified as a type of secondary osteoarthrosis. In this connection it may he mentioned that exercising joints of aging mice failed to increase the incidence or severity of osteoarthrosis above that occurring spontaneously (8). The term "wear and tear" might be more meaningful if it was applied on the cellular level in order to indicate functional deterioration of chondrocytes and matrix with the passage of time.…”
Section: Smentioning
confidence: 99%