The effects of exercise on the knee‐joints of inbred mice

Lanier, Raymond R.

doi:10.1002/ar.1090940307

Cited by 33 publications

(15 citation statements)

References 7 publications

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“…1980] give rise to alterations of the articular cartilage. However, it is also evident that longterm training of experimental animals does not unavoidably lead to de generative changes of the articular cartilage [Lanier, 1946;Sciaf, 1950],…”

Section: Introductionmentioning

confidence: 99%

Influences of Joint Immobilization and Running Exercise on Articular Cartilage Surfaces of Young Rabbits

Jurvelin

Helminen

Lauritsalo

et al. 1985

Cells Tissues Organs

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The influences of joint immobilization and running exercise on the articular cartilage surfaces of the patella and lateral tibial condyle of young rabbits were investigated by the semiquantitative stereomicroscopic and scanning electron microscopic methods during a period of 8 weeks. The smoothness of the articular surfaces was disturbed already 1 week after the onset of immobilization. Leafy, slightly rough and rough surface qualities associated with superficial splits were observed. The changes were of the same nature after a longer period of immobilization. Running exercise on the treadmill (150–300 m twice a day, 12–24 min per turn, 5 times a week) led to an increase of the striated surface quality at 1 to-2-week intervals as compared with the controls. It was apparent that during immobilization remarkable changes of the articular cartilage took place within the first week, while running exercise up to 8 weeks elicited only transient or minor alterations of the articular surface.

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Section: Introductionmentioning

confidence: 99%

Influences of Joint Immobilization and Running Exercise on Articular Cartilage Surfaces of Young Rabbits

Jurvelin

Helminen

Lauritsalo

et al. 1985

Cells Tissues Organs

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“…It is possible that the differences in the incidence of osteoarthrosis in different strains of mice (58) might be attributable to the genetically deter mined rate of aging of the cartilage. In the mouse, at least, mechanical factors play a subordinate role in the pathogenesis of osteoarthrosis since in mice of strain D increased use of the knee joints had no effect on the frequency or severity of articular degeneration (24). Moreover, the different location of de generative changes within the knee joint in a number of murine strains could not be explained in terms of mechanical factors (57).…”

Section: Discussionmentioning

confidence: 99%

Age-Related Histochemical and Histological Changes in the Knee-Joint Cartilage of C57B1 Mice and Their Significance for the Pathogenesis of Osteoarthrosis

Pataki¹,

Rüttner²,

Abt³

1980

Pathobiology

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For a better understanding of the part played by the aging of cartilage in the pathogenesis of osteoarthrosis, we attempted to detect functional age-related changes in the knee-joint cartilage of C57B1 mice using histochemical methods and to correlate these changes with the concomitant histological changes. A comparison of 57- and 97-week-old mice revealed a statistically significant age-related focal loss of activity for a number of oxidative enzymes of the chondrocytes. There was an associated significant increase in regressive changes of the chondrocytes. A relation probably exists between these two changes, inasmuch as the focal loss of enzyme activity precedes and possibly gives rise to the regressive changes. A comparison with the changes described in the articular cartilage of other species including man suggests that the phenomena observed are inherent age-related changes. The loss of activity of all the enzymes investigated indicates a far-reaching derangement of cellular metabolism, leading to impaired synthesis of proteoglycans. Since these compounds are major determinants of the physical properties of articular cartilage, the changes described might render the cartilage more vulnerable and might thus play a major part in the pathogenesis of osteoarthrosis.

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“…However, function preserves rather than injures cartilage and minimal trauma would hardly affect intact articulations: on the other hand, joint disease resulting from severe trauma would have to be classified as a type of secondary osteoarthrosis. In this connection it may he mentioned that exercising joints of aging mice failed to increase the incidence or severity of osteoarthrosis above that occurring spontaneously (8). The term "wear and tear" might be more meaningful if it was applied on the cellular level in order to indicate functional deterioration of chondrocytes and matrix with the passage of time.…”

Section: Smentioning

confidence: 99%