Pathogenesis of Osteoarthrosis

Silberberg, Ruth; Silberberg, Martin

doi:10.1159/000161494

Cited by 7 publications

(7 citation statements)

References 9 publications

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“…According to Silberberg and Silberberg. age might therefore either be the pacemaker of osteo arthrosis (42,53) or might render the articular cartilage vulnerable to other noxae (50). It is possible that the differences in the incidence of osteoarthrosis in different strains of mice (58) might be attributable to the genetically deter mined rate of aging of the cartilage.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to hereditary, metabolic, endocrine and mechanical influences, age changes are being considered as a possible pathogenetic factor though opinions differ as to their importance. According to Silberberg and Silberberg (42,50,53) aging of the articular cartilage plays a dominant role, but other authors, while recognizing the role of aging, stress the importance of other factors (9,11).…”

Section: Introductionmentioning

confidence: 99%

“…As the model for our in vestigation we chose spontaneous gonarthrosis in the mouse (41), since this condition appears to be comparable with human osteoarthrosis. The use of this model for our investigation is probably all the more justified, since it has been shown under various experimental conditions to be responsive to factors which are thought to be involved in human osteoarthrosis (53,61).…”

Section: Introductionmentioning

confidence: 99%

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Age-Related Histochemical and Histological Changes in the Knee-Joint Cartilage of C57B1 Mice and Their Significance for the Pathogenesis of Osteoarthrosis

Pataki¹,

Rüttner²,

Abt³

1980

Pathobiology

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For a better understanding of the part played by the aging of cartilage in the pathogenesis of osteoarthrosis, we attempted to detect functional age-related changes in the knee-joint cartilage of C57B1 mice using histochemical methods and to correlate these changes with the concomitant histological changes. A comparison of 57- and 97-week-old mice revealed a statistically significant age-related focal loss of activity for a number of oxidative enzymes of the chondrocytes. There was an associated significant increase in regressive changes of the chondrocytes. A relation probably exists between these two changes, inasmuch as the focal loss of enzyme activity precedes and possibly gives rise to the regressive changes. A comparison with the changes described in the articular cartilage of other species including man suggests that the phenomena observed are inherent age-related changes. The loss of activity of all the enzymes investigated indicates a far-reaching derangement of cellular metabolism, leading to impaired synthesis of proteoglycans. Since these compounds are major determinants of the physical properties of articular cartilage, the changes described might render the cartilage more vulnerable and might thus play a major part in the pathogenesis of osteoarthrosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Age-Related Histochemical and Histological Changes in the Knee-Joint Cartilage of C57B1 Mice and Their Significance for the Pathogenesis of Osteoarthrosis

Pataki¹,

Rüttner²,

Abt³

1980

Pathobiology

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“…Intensified joint motion and the resulting improved nutrition of the cartilage would create a favorable environment for chondrocytes; after a period of relatively high activity, however, they age and die more rapidly than those kept under nutritionally marginal conditions (Silberberg & Silberberg, 1964). The fact that some degradative enzymes were shown to be more active in the fixed socket than in the movable head of the humeral would be consistent with this suggestion and with increased activity of some lysosomal enzymes observed following prolonged compression of the articular cartilage (Thompson & Clerk, 1970).…”

Section: Discussionmentioning

confidence: 99%

Aging of the Shoulder Joint of Guinea Pigs. Electron Microscopic and Quantitative Histochemical Aspects

Silberberg¹,

Hasler²,

1973

Journal of Gerontology

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“…Spontaneous osteo-arthritis of the knee-joint in mice has been used as a model for studying the aetiopathogenesis of the human disease [1][2][3][4][5] and also for pharmacological investigations of potential arthrosis-suppressing or arthrosis-promoting drugs [6,7]. Since murine osteo-arthritis is mainly evaluated by histopathological examination, wider use of this model in pharmacological research is limited by the considerable amount of time and labour needed to demonstrate a pharmacological effect.…”

Section: Introductionmentioning

confidence: 99%

Quantitative radiographic diagnosis of osteo-arthritis of the knee-joint in the C57BL mouse

et al. 1990

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Comparative histopathological and radiographic investigations in the C57BL mouse model of spontaneous osteo-arthritis of the knee-joint indicate that there is a relation between quantitative radiographic diagnosis and semiquantitative histopathological diagnosis. Statistical analysis based on a set of quantitative radiographic parameters of the mouse knee-joint shows that the greater part of the radiographic information reflecting the histopathological degree of the osteo-arthritis is contained in the projection areas of the lateral and medial meniscus: progression of the osteo-arthritic process is accompanied with enlargement of the menisci. On the basis of these observations, a radiography score for the osteo-arthritis has been constructed, which consists of a weighted sum of the - suitably transformed - projection areas of the lateral and medial meniscus. In addition to the size of the menisci, the width of the joint space is also a useful quantitative parameter of osteo-arthritis of the mouse knee-joint.

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Pathogenesis of Osteoarthrosis

Cited by 7 publications

References 9 publications

Age-Related Histochemical and Histological Changes in the Knee-Joint Cartilage of C57B1 Mice and Their Significance for the Pathogenesis of Osteoarthrosis

Age-Related Histochemical and Histological Changes in the Knee-Joint Cartilage of C57B1 Mice and Their Significance for the Pathogenesis of Osteoarthrosis

Aging of the Shoulder Joint of Guinea Pigs. Electron Microscopic and Quantitative Histochemical Aspects

Quantitative radiographic diagnosis of osteo-arthritis of the knee-joint in the C57BL mouse

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