Aging of the Shoulder Joint of Guinea Pigs. Electron Microscopic and Quantitative Histochemical Aspects

Silberberg, Ruth; Hasler, Mary; Pa, Lesker

doi:10.1093/geronj/28.1.18

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Changes In the Skeleton And Musculature With Age1

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1974

1983

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Cited by 6 publications

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“…In older animals, the level of cross-linking is increased, with the result that most of the polpeptides are linked within and between the molecules. Silberberg et al (19) examined the shoulder joint of guinea pigs (2 weeks to 5 years, nine months of age) with electron microscopy to determine the activity of nine glycolytic and four lysosomal enzymes. Findings were then compared with data previously obtained for joints of the lower extremity.…”

Section: Changes In the Skeleton And Musculature With Agementioning

confidence: 99%

Laboratory Rodents and Experimental Gerontology II¹

1983

Gerodontology

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Section: Changes In the Skeleton And Musculature With Agementioning

confidence: 99%

Laboratory Rodents and Experimental Gerontology II¹

1983

Gerodontology

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Periodic fibrillar material in intracellular vesicles and in electron‐dense bodies in chondrocytes of rat costal and tracheal cartilage at various ages

Dearden

1975

Am. J. Anat.

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The occurrence of intracellular fibrillar material (frequently banded) has been studied in normal costal and tracheal chondrocytes of rats at various ages ranging from 1 to 90 days. The study methods have included digestion with collagenase, electron histochemical techniques and routine electron microscopy. Banded fibrillar material has been observed intracellularly in vesicles or in electron-dense bodies in perichondrial and subperichondrial chondrocytes from rats of all ages. These fibrils and extracellular collagen fibrils are partially and equally degradable by collagenase, they are positive after staining with phosphotungstic acid or with silver nitrate methenamine, and their lucency corresponds with that of collagen when they are stained only with lead citrate. They have not been observed in intracellular clefts. They, therefore, seem to be formed intracellularly and to be exocytosed subsequently. Large vesicles and electron-dense bodies seem to be derived from Golgi saccules. A mechanism whereby banded intracellular fibrils could be formed from tropocollagen molecules is postulated. The frequency of occurrence and the diameter of intracellular fibrils seems to increase with increasing age.

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