The Effects of Ethanolic Leaf Extract of Commiphora africana (Buseraceae) on Lipid Profile in Rats

Medicinal plants are the richest bioresources of drugs. There is need to validate medicinal and aromatic plants researches results through an organized database. Objective: To identify the terpenoids in Commiphora africana resin and some biological activity specially antiviral activity. Materials and Methods: Two different methods were done to identify Terpenoids in this resin, dipping the resin in CH 2 Cl 2 and isolation using column chromatography [1], ethanol and water extract were extracted for phytochemical screening and the biological aspects. Results: Phytochemical screening identified that Flavonoids, Saponins, Alkaloids and Terpenes were the major constituents of C. africana resin ethanolic and water extracts. GC-MS analysis of CH 2 Cl 2 extract and the isolated samples by column chromatography revealed compounds which Original Research Articlecan play important role in therapy, so as Betulin C 30 H 50 O 2 . Urs-12-en-28-al, 3-(acetyloxy) C 32 H 50 O 3 . Cholest-22-ene-21-ol, 3-5-dehydro-6-methoxy-, pivalate C 33 H 54 O 3 and Phthalic acid, bis(2-pentyl) ester C 18 H 26 O 4 . LC50 values of water and ethanolic extracts were found to be 100 and 630.9 respectively. While the LC50 for the aqueous water solution of the crude resin was found to be 63.1. High and clear antiviral activity towards Newcastle virus was observed at 400 ug/ml C. africana water solution, 400 ug/ml C. africana water extract and 100, 200, 400, 500 ug/ml C. africana ethanol extract. The highest antimicrobial activity recorded was obtained for C. africana ethanol extract against Staphylococcus aureus, Klebsiella porwonia, Asperogillus niger and Candida Albicans. Conclusion: Antiviral activity shown by Commiphora africana resin extracts may be due to different compounds included.

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“…It is used traditionally for many purposes, treat measles, insecticides, antilipidaemic and management of cardiovascular disorders [4].…”

Section: Photo 1 C Africana Resin Photo 2 C Africana Treementioning

confidence: 99%

Commiphora africana Resin Phytochemical Analysis & Some Biological Aspects

Ahmed

Gadir

Elgilany³

et al. 2016

EJMP

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“…The toxicological implications of varying doses of medicinal supplements have been reported to range from severe dyslipidemia to hypolipidemia (Perez et al, 1999;Adebayo et al, 2006;Ogbonnia et al, 2010;Patrick-Iwuanyanwu et al, 2012;Haza et al, 2016;).…”

Section: Introductionmentioning

confidence: 99%

Methanol leaf extract of Simarouba glauca induced dyslipidemia-linked cardiovascular disease indicators and its effect on antioxidant proteins

Osagie-Eweka¹,

Orhue²,

Omogbai³

et al. 2022

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The study focused on the effect of methanol leaf extract of Simarouba glauca (MESG) on lipoproteins cholesterols and oxidative stress biomarkers in male Wistar rat. Toxicological inquest of MESG was evaluated as prescribed in the guidelines of organization for economic co-operation and development (OECD), No. 425. A total of twenty-four male Wistar rats were used; divided into four groups of six rats each, including the control. Test rats were given MESG 500, 1000 and 2000 mg/kg body weight respectively, daily for thirty (30) days. At the end of the study, the rats were fasted overnight and sacrificed and biochemical indicators were evaluated. Results showed marked increase (p ˂ 0.05) in Total Cholesterol at MESG 2000 mg/kg; a reduction and increase (p ˂ 0.05) in High-Density Lipoprotein Cholesterol and Triglycerides respectively, at all doses; an increase (p ˂ 0.05) in Low- Density Lipoprotein Cholesterol at MESG 2000 mg/kg. Additional data indicated no changes (p ˃ 0.05) in Malondialdehyde levels; liver Catalase was significantly (p ˂ 0.05) expressed at MESG 500 and 2000 mg/kg, kidney CAT was significantly (P ˂ 0.05) expressed at all doses. The liver Superoxide Dismutase (SOD) was significantly (p ˂ 0.05) expressed at MESG 1000 and 2000 mg/kg; the kidney and heart SOD were also significantly (P ˂ 0.05) expressed at MESG 500 and 2000 mg/kg respectively. The plasma GSH-PX was significantly (P ˂ 0.05) expressed at MESG 1000 mg/kg; while the liver and heart GSH-PX were significantly (P ˂ 0.05) expressed and repressed at 500 mg/kg respectively. Conclusively, MESG elicited obvious dyslipidemia; accompanied by marked alterations in selected endogenous oxidative stress biomarkers.

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Resveratrol derivatives from Commiphora africana (A. Rich.) Endl. display cytotoxicity and selectivity against several human cancer cell lines

Segun

Ogbole

Ismail

et al. 2018

Phytotherapy Research

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Commiphora africana (A. Rich.) Endl. (Burseraceae) is a medicinal plant widely used in Nigerian ethnomedicine. The in vitro cytotoxicity of the stem bark extract of C. africana and isolated cytotoxic compounds was investigated. Three resveratrol derivatives: (E)-resveratrol 3-O-rutinoside (1), 5-methoxy-(E)-resveratrol 3-O-rutinoside (2), and pinostilbene (3), together with 3-hydroxy-5-methoxybenzoic acid (4) were isolated from the methanol fraction of C. africana. Their structures were determined by extensive analysis of their HREIMS and NMR spectra. The cytotoxicity of the isolated compounds against four human carcinoma cells was determined using the MTT assay. Compound 1 displayed the highest antiproliferative effect on the cell lines, with IC 50 values of 16.80, 21.74, 17.89, and 17.44 μM, against MCF7, A549, PC3, and HepG2 human cancer cell lines, respectively. In addition, compounds 1-3 showed low toxicity against normal human prostate cell line, with selectivity indices greater than five across the carcinoma cells, indicating that the compounds possess potential in the development of low-toxicity chemotherapeutic agents. These results support the traditional use of this plant in the treatment of cancer.

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The Effects of Ethanolic Leaf Extract of Commiphora africana (Buseraceae) on Lipid Profile in Rats

Cited by 25 publications

References 9 publications

Commiphora africana Resin Phytochemical Analysis & Some Biological Aspects

Commiphora africana Resin Phytochemical Analysis & Some Biological Aspects

Methanol leaf extract of Simarouba glauca induced dyslipidemia-linked cardiovascular disease indicators and its effect on antioxidant proteins

Resveratrol derivatives from Commiphora africana (A. Rich.) Endl. display cytotoxicity and selectivity against several human cancer cell lines

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