Commiphora africana Resin Phytochemical Analysis & Some Biological Aspects

Abstract

Medicinal plants are the richest bioresources of drugs. There is need to validate medicinal and aromatic plants researches results through an organized database. Objective: To identify the terpenoids in Commiphora africana resin and some biological activity specially antiviral activity. Materials and Methods: Two different methods were done to identify Terpenoids in this resin, dipping the resin in CH 2 Cl 2 and isolation using column chromatography [1], ethanol and water extract were extracted for phytochemical screening and the biological aspects. Results: Phytochemical screening identified that Flavonoids, Saponins, Alkaloids and Terpenes were the major constituents of C. africana resin ethanolic and water extracts. GC-MS analysis of CH 2 Cl 2 extract and the isolated samples by column chromatography revealed compounds which Original Research Articlecan play important role in therapy, so as Betulin C 30 H 50 O 2 . Urs-12-en-28-al, 3-(acetyloxy) C 32 H 50 O 3 . Cholest-22-ene-21-ol, 3-5-dehydro-6-methoxy-, pivalate C 33 H 54 O 3 and Phthalic acid, bis(2-pentyl) ester C 18 H 26 O 4 . LC50 values of water and ethanolic extracts were found to be 100 and 630.9 respectively. While the LC50 for the aqueous water solution of the crude resin was found to be 63.1. High and clear antiviral activity towards Newcastle virus was observed at 400 ug/ml C. africana water solution, 400 ug/ml C. africana water extract and 100, 200, 400, 500 ug/ml C. africana ethanol extract. The highest antimicrobial activity recorded was obtained for C. africana ethanol extract against Staphylococcus aureus, Klebsiella porwonia, Asperogillus niger and Candida Albicans. Conclusion: Antiviral activity shown by Commiphora africana resin extracts may be due to different compounds included.

Repellency and Toxicity of Selected Fractions, Identified Compounds and Blends of Commiphora africana Resin Against Bedbugs

“…The dichloromethane resin extract showed significantly ( P < .05) higher mean repellency than the hexane, ethyl acetate, methanol, and water crude extracts (Table 1). The hexane and dichloromethane resin extracts exhibited higher mean repellencies of 98.5% and 100.0%, respectively, at 12 h exposure against bedbugs than the ethyl acetate (82.5%), methanol (75.0%), and water (72.5%) resin extracts (Table 1) due to the presence of high levels of nonpolar and mid-polar compounds which possess potential and beneficial biological properties, such as insecticidal and fungicidal, as previously reported by Ahmed et al 9 At the 30-minute period of exposure of the bedbugs to the treatments, neocidol (positive control) demonstrated significantly ( P < .05) higher mean repellency as compared to the hexane, dichloromethane, ethyl acetate, methanol, and water resin crude extracts. However, after 1, 6, and 12 h exposure of the bedbugs to the treatments, the dichloromethane resin extract had a significantly ( P < .05) higher mean repellency than neocidol (Table 1).…”

Anti-proliferative activity of a novel tricyclic triterpenoid acid from Commiphora africana resin against four human cancer cell lines

“…The resin of C. africana contains betulin [7], which has been shown to have antitumor activity, especially in combination with cholesterol [8]. Betulinic acid derivatives can inhibit HIV-1 [9].…”

PLANT EXTRACTS AS CORROSION INHIBITORS FOR ALUMINUM ALLOY IN NaCL ENVIRONMENT - RECENT REVIEW

“…(2) dissolving of the solute in the solvent; (3) the solute diffuses out of the matrix; (4) the solute extracted is collected. Extraction is further facilitated by any of the factors enhancing diffusivity and solubility [29].…”