The Effects of Estrogen on Serum Level and Hepatocyte Expression of PCSK9

Guo, Wen; Fu, Jinxiang; Chen, Xiaoli; Gao, Beibei; Fu, Zhen-Yan; Fan, Haozhi; Cui, Qin; Zhu, Xiaohui; Zhao, Yang; Yang, Tao; Fan, Daping; Zhou, Hongwen

doi:10.1016/j.metabol.2015.01.009

Cited by 20 publications

(12 citation statements)

References 20 publications

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“…The mechanisms underlying the sex differences observed in PCSK9 levels remain unclear; however, most of the data to date suggest that estrogen suppresses PCSK9. Although estrogen replacement does not significantly alter plasma PCSK9 in postmenopausal females, high‐dose estradiol treatment suppresses hepatic PCSK9 expression in rats . Moreover, plasma PCSK9 is higher in postmenopausal compared with premenopausal women, and is inversely correlated with endogenous estrogen levels in healthy women .…”

Section: Discussionmentioning

confidence: 99%

Obesity and type 2 diabetes are associated with elevated PCSK9 levels in young women

et al. 2017

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Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of low-density lipoprotein (LDL) cholesterol and cardiovascular disease (CVD) risk, and is an emerging therapeutic target. Objective We compared serum PCSK9 levels in young adults, with and without type 2 diabetes. Subjects and Methods Cross-sectional analysis was conducted in a cohort, aged 15 to 26 years, in Cincinnati, OH, from 2005 to 2010. Serum PCSK9 levels were measured in 94 youth with type 2 diabetes, 93 obese control subjects, and 99 lean control subjects. Correlative analyses were conducted to determine significant covariates of PCSK9 by group and sex, and multivariate linear regression models were used to study the independent determinants of PCSK9. Results In females, PCSK9 levels were significantly increased in the obese and type 2 diabetes subjects relative to the lean controls (P < 0.01). Moreover, PCSK9 was positively correlated with multiple metabolic parameters in females: body mass index (BMI), systolic blood pressure (SBP), fasting glucose, fasting insulin, and C-reactive protein (CRP) levels (P≤0.02). In males, PCSK9 levels were decreased overall compared to females (P=0.03), and did not differ between the lean, obese, or type 2 diabetes groups. Conclusions Obesity and type 2 diabetes were associated with significantly higher levels of PCSK9 in young women, but not in young men. These data suggest that sex could modify the effects of obesity and diabetes on PCSK9 in young adults.

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Section: Discussionmentioning

confidence: 99%

Obesity and type 2 diabetes are associated with elevated PCSK9 levels in young women

et al. 2017

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“…Decline in estrogen concentrations was linked to dyslipidemia in peri- and post-menopausal women, including increased serum triglyceride (TG) levels [2, 3]. Guo et al [2] reported that TG levels of postmenopausal women were significant higher than that of pre-menopausal women (1.73 ± 0.98 vs 1.07 ± 0.63 mmol/L, P < 0.05). Whitcroft et al [4] reported that transdermal estradiol treatment for post-menopausal women could lower serum TG levels by about 16.4% ( P < 0.01).…”

Section: Introductionmentioning

confidence: 99%

Estrogen lowers triglyceride via regulating hepatic APOA5 expression

et al. 2017

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Estrogen had been found to be negatively associated with serum triglyceride (TG) levels. Apolipoprotein A5 (APOA5), a novel member of apolipoprotein family, was reported to have a strong ability to decrease serum concentrations of TG. Clinical data found concentrations of APOA5 were higher in woman than that in men, and the negative relationship between APOA5 and TG levels was more significant in woman. These suggests APOA5 may involve in estrogen actions. Therefore, we hypothesize estrogen up-regulates serum concentrations of APOA5 and subsequently decreases serum TG levels. We will design the following experiments to test this hypothesis. (1) We will treat wild and APOA5-defeted ovariectomized hamster with or without estrogen to examine if estrogen could up-regulate concentrations of APOA5 and decrease TG levels. (2) We will treat HepG2 cells with estrogen and investigate the possible mechanisms.

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“…Triglyceride concentration did not differ between pre-and postmenopausal women. Meanwhile, Guo et al [32] have reported significantly higher levels of triglyceride in postmenopausal women compared to premenopausal. It seems like the variation in the plasma triglyceride concentration cannot be linked directly to pre-or postmenopausal status.…”

Section: Discussionmentioning

confidence: 99%

Lipid Profile and Prevalence of Dyslipidemia in Pre- and Postmenopausal Women in Yaounde, Cameroon

Nkeunen

Judith

Simo

et al. 2019

IJBcRR

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Aims: Lipids serve several important physiologic functions like energy homeostasis or biosynthesis of hormone within the human body. The deterioration of lipid metabolism which is favoured by menopause is the source of cardiovascular diseases. This study aimed to determine the plasma lipid profile and dyslipidemia prevalence of some Cameroonian women. Methodology: To achieve this goal, two sets of 105 postmenopausal and 127 premenopausal Nkeunen et al.; IJBCRR, 25(4): 1-11, 2019; Article no.IJBCRR.48605 2 participants were enrolled in this study. 5ml of blood were collected on EDTA coated tubes from each participant. Enzymatic methods were used to evaluate total cholesterol, HDL cholesterol and triglyceride, while LDL cholesterol was determined using the Friedewald equation. These biological parameters were used to determine dyslipidemia. Thereafter, they were compared within age and year since menopause subgroups. Results: There was no significant difference in the mean values of total cholesterol, HDL-C, LDL-C as well as triglyceride between premenopausal and postmenopausal women. The mean HDL-C concentration was stable in the age subgroups while the mean total cholesterol and LDL-C were slightly increasing as postmenopausal participants got older. LDL-C level was significantly higher in women who had been in menopause for more than 15 years. The overall dyslipidemia prevalence was 53%. Dyslipidemia was significantly higher in the subgroup of women who had freshly entered menopause. Conclusion: Even though there was no change in the mean concentration of the plasma lipid parameters, of pre-and postmenopausal participants there was a general need to improve their lifestyle in order to reduce dyslipidemia prevalence. Original Research Article

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The Effects of Estrogen on Serum Level and Hepatocyte Expression of PCSK9

Cited by 20 publications

References 20 publications

Obesity and type 2 diabetes are associated with elevated PCSK9 levels in young women

Obesity and type 2 diabetes are associated with elevated PCSK9 levels in young women

Estrogen lowers triglyceride via regulating hepatic APOA5 expression

Lipid Profile and Prevalence of Dyslipidemia in Pre- and Postmenopausal Women in Yaounde, Cameroon

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