Lipid Profile and Prevalence of Dyslipidemia in Pre- and Postmenopausal Women in Yaounde, Cameroon

Abstract

Aims: Lipids serve several important physiologic functions like energy homeostasis or biosynthesis of hormone within the human body. The deterioration of lipid metabolism which is favoured by menopause is the source of cardiovascular diseases. This study aimed to determine the plasma lipid profile and dyslipidemia prevalence of some Cameroonian women. Methodology: To achieve this goal, two sets of 105 postmenopausal and 127 premenopausal Nkeunen et al.; IJBCRR, 25(4): 1-11, 2019; Article no.IJBCRR.48605 2 participants were enrolled in this study. 5ml of blood were collected on EDTA coated tubes from each participant. Enzymatic methods were used to evaluate total cholesterol, HDL cholesterol and triglyceride, while LDL cholesterol was determined using the Friedewald equation. These biological parameters were used to determine dyslipidemia. Thereafter, they were compared within age and year since menopause subgroups. Results: There was no significant difference in the mean values of total cholesterol, HDL-C, LDL-C as well as triglyceride between premenopausal and postmenopausal women. The mean HDL-C concentration was stable in the age subgroups while the mean total cholesterol and LDL-C were slightly increasing as postmenopausal participants got older. LDL-C level was significantly higher in women who had been in menopause for more than 15 years. The overall dyslipidemia prevalence was 53%. Dyslipidemia was significantly higher in the subgroup of women who had freshly entered menopause. Conclusion: Even though there was no change in the mean concentration of the plasma lipid parameters, of pre-and postmenopausal participants there was a general need to improve their lifestyle in order to reduce dyslipidemia prevalence. Original Research Article

Dyslipidemia in Post-menopausal Women of Western Nepal: A Community-Based Comparative Study

“…There have been limited studies from Nepal regarding the prevalence of dyslipidemia among post-menopausal women. A study from Cameroon showed a high prevalence of dyslipidemia at 61%, especially among females recently entering menopause [16]. Another study from Beijing also reported a high prevalence of dyslipidemia (69.7%) in postmenopausal women [17].…”