The effects of escitalopram on working memory and brain activity in healthy adults during performance of the n-back task

Rose, Emma Jane; Simonotto, Enrico; Spencer, Edgar P.; Ebmeier, Klaus P.

doi:10.1007/s00213-006-0334-2

Cited by 47 publications

(47 citation statements)

References 45 publications

(51 reference statements)

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“…Thalamocortical coupling is altered in depression and antidepressant therapy targets this connection [26][27][28]. HC healthy control subjects, rMD remitted depressed subjects, aMD acute depressed patients fMRI-1 functional magnetic resonance imaging session one, HAM-D 24 Hamilton Depression Rrating Scale (24 item version), HAM-A Hamilton Anxiety Rating Scale, BDI Beck Depression Index, CGI Clinical Global Impression scale, f female, m male, y years, m months, r right, l left a p-value chi-square test b p-value analysis of variance c p-value t-test d for detiailed medication see supplementary Table S5 e only one patient Antidepressant effects on the pulvinar and the thalamus are substantiated in other fMRI tasks [29][30][31]. Moreover, thalamocortical connectivity was altered upon ketamine administration [32] and transracial magnetic stimulation to the dorsolateral prefrontal cortex elevated activity in the pulvinar nuclei [33].…”

Section: Discussionmentioning

confidence: 99%

The pulvinar nucleus and antidepressant treatment: dynamic modeling of antidepressant response and remission with ultra-high field functional MRI

et al. 2018

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Functional magnetic resonance imaging (fMRI) successfully disentangled neuronal pathophysiology of major depression (MD), but only a few fMRI studies have investigated correlates and predictors of remission. Moreover, most studies have used clinical outcome parameters from two time points, which do not optimally depict differential response times. Therefore, we aimed to detect neuronal correlates of response and remission in an antidepressant treatment study with 7 T fMRI, potentially harnessing advances in detection power and spatial specificity. Moreover, we modeled outcome parameters from multiple study visits during a 12-week antidepressant fMRI study in 26 acute (aMD) patients compared to 36 stable remitted (rMD) patients and 33 healthy control subjects (HC). During an electrical painful stimulation task, significantly higher baseline activity in aMD compared to HC and rMD in the medial thalamic nuclei of the pulvinar was detected (p = 0.004, FWE-corrected), which was reduced by treatment. Moreover, clinical response followed a sigmoid function with a plateau phase in the beginning, a rapid decline and a further plateau at treatment end. By modeling the dynamic speed of response with fMRI-data, perigenual anterior cingulate activity after treatment was significantly associated with antidepressant response (p < 0.001, FWE-corrected). Temporoparietal junction (TPJ) baseline activity significantly predicted non-remission after 2 antidepressant trials (p = 0.005, FWE-corrected). The results underline the importance of the medial thalamus, attention networks in MD and antidepressant treatment. Moreover, by using a sigmoid model, this study provides a novel method to analyze the dynamic nature of response and remission for future trials.

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Section: Discussionmentioning

confidence: 99%

The pulvinar nucleus and antidepressant treatment: dynamic modeling of antidepressant response and remission with ultra-high field functional MRI

et al. 2018

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“…It is alleged, but yet unsubstantiated, that psychotropic agents reduce the BOLD signal (Goldman et al, 1996;Rose et al, 2006). It is unlikely that the present results are fully explained by medication effects given that highly symptomatic participants had greater activity for one condition and simultaneously lower activity for another condition and vice-versa, depending on the brain region.…”

Section: Strengths and Limitationsmentioning

confidence: 72%

Neural systems for executive and emotional processing are modulated by symptoms of posttraumatic stress disorder in Iraq War veterans

Morey

Petty

Cooper

et al. 2008

Psychiatry Research: Neuroimaging

112

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The symptom provocation paradigms generally used in neuroimaging studies of posttraumatic stress disorder (PTSD) have placed high demands on emotion processing but lacked cognitive processing, thereby limiting the ability to assess alterations in neural systems that subserve executive functions and their interactions with emotion processing. Thirty-nine veterans from Iraq and Afghanistan underwent functional MR imaging while exposed to emotional combat-related and neutral civilian scenes interleaved with an executive processing task. Contrast activation maps were regressed against PTSD symptoms as measured by the Davidson Trauma Scale. Activation for emotional compared to neutral stimuli was highly positively correlated with level of PTSD symptoms in ventral frontolimbic regions, notably the ventromedial prefrontal cortex, inferior frontal gyrus, and ventral anterior cingulate gyrus. Conversely, activation for the executive task was negatively correlated with PTSD symptoms in the dorsal executive network, notably the middle frontal gyrus, dorsal anterior cingulate gyrus, and inferior parietal lobule. Thus, there is a strong link between the subjectivelyassessed behavioral phenomenology of PTSD and objective neurobiological markers. These findings extend the largely symptom provocation-based functional neuroanatomy to provide evidence that interrelated executive and emotional processing systems of the brain are differentially affected by PTSD symptomatology in recently deployed war veterans.

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“…An alteration in blood flow in the regions of thalamus, hypothalamus, and cingulate cortex (Geday et al 2005) and their resultant changes in brain activity have been reported following administration of SSRIs; intravenous administration of citalopram resulted in a time-dependent activation in the thalamus, amygdala, hippocampus, caudate, and striatum (McKie et al 2005). A chronic course of escitalopram treatment for a period of 7 days produced regionally specific activation in the thalamus and anterior cingulate and a decreased activation in inferior frontal gyrus, highlighting the regions susceptible to antidepressant exposure (Rose et al 2006). Similar results have also been reported following fluoxetine or paroxetine administration in healthy subjects (Loubinoux et al 2002).…”

Section: Discussionmentioning

confidence: 95%

Neuroadaptive responses to citalopram in rats using pharmacological magnetic resonance imaging

et al. 2010

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The effects of escitalopram on working memory and brain activity in healthy adults during performance of the n-back task

Cited by 47 publications

References 45 publications

The pulvinar nucleus and antidepressant treatment: dynamic modeling of antidepressant response and remission with ultra-high field functional MRI

The pulvinar nucleus and antidepressant treatment: dynamic modeling of antidepressant response and remission with ultra-high field functional MRI

Neural systems for executive and emotional processing are modulated by symptoms of posttraumatic stress disorder in Iraq War veterans

Neuroadaptive responses to citalopram in rats using pharmacological magnetic resonance imaging

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