The Effects of Epidural Anaesthesia and Analgesia on Natural Killer Cell Cytotoxicity and Cytokine Response in Patients with Epithelial Ovarian Cancer Undergoing Radical Resection

Effect of anaesthetic technique on the natural killer cell anti-tumour activity of serum from women undergoing breast cancer surgery: a pilot study

“…38 A study of breast cancer patients' serum found reduced serum IL-1b after operation with PPA anaesthesia compared with GA. 33 Another clinical study of ovarian cancer showed attenuated increase in serum IL-1b with a regional anaesthetic technique. 34 However, sedation with propofolketamine did not modify plasma concentrations of IL-1b, IL-2, IL-6, IL-10, IL-8, IL-12p70, or IFN-g or the T helper cell 1/2 ratio in children with leukaemia undergoing bone marrow aspiration. 39 Isoflurane suppressed glial cell IL-1b up-regulation and plasma ACTH but not plasma IL-1b in intraperitoneal lipopolysaccharide inoculated mice.…”

Comparing the Effects of Combined General/Epidural Anaesthesia and General Anaesthesia on Serum Cytokine Levels in Radical Cystectomy

“…Çeşitli kanser türlerinde GA ve kombine GEA altında radikal rezeksiyon geçiren hastalarda IL-1β en çok araştırılan sitokinlerin başında gelmektedir. Over ve servikal tümör cerrahilerinde serum IL-1β kombine GEA uygulanan grupta postoperatif dönemde anlamlı düzey-de düşük bulunmuştur (18,19) Gastrik kanser cerrahisinde Kun ve ark. (9) epidural anestezinin postoperatif erken dö-nemde protümörojenik IL1-β ve IL-6 düzeylerini genel anesteziye göre anlamlı düzeyde azalttığını perioperatif immün fonksiyonların korunduğunu bildirmiştir.…”

Epigenetics in the perioperative period

“…Direct effects could include the interference of local anaesthetics with tumour-promoting pathways (Votta-Velis et al, 2013), direct toxic effects when used for local infiltration (Schlagenhauff et al, 2000) and changes in the epigenetic signature of tumour cells (Lirk et al, 2012). Indirect effects could result from reduction of the perioperative stress response and the preservation of the immune response (Dong et al, 2012). As many of these effects can be duplicated using i.v.…”