Comparing the Effects of Combined General/Epidural Anaesthesia and General Anaesthesia on Serum Cytokine Levels in Radical Cystectomy

Karadeniz, Meltem Savran; Mammadov, Orkhan; Ciftci, Hayriye Senturk; Usta, Sebahat Akgul; Pembeci, Kamil

doi:10.5152/tjar.2017.13285

Cited by 5 publications

(2 citation statements)

References 23 publications

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“…In the present study, there was no significant correlation between gender and age with MCP-1 and CD16 immune markers, and these results are in agreement with Karadeniz et al and De Toda et al [22,25]. In the present study, there was no significant correlation between the duration of anesthesia and immune markers (MCP-1 and CD16), and these results are in agreement with Song et al [26].…”

Section: Discussionsupporting

confidence: 92%

Effects of Anesthesia on Innate Immune Components in Orthopedic Surgery

Aubaid

Yassen

2018

Asian J Pharm Clin Res

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Objectives: The present study was carried out to evaluate the possible role of anesthetics and surgery on innate by measuring the levels of tumor necrosis factor alpha (TNFα) and interferon gamma (IFNγ) by enzyme-linked immunosorbent assay (ELISA). Flow cytometry was used to determine MCP-I and CD16.Methods: Serum level of TNFα and IFNγ cytokines was measured using ELISA technique. Flow cytometry was used to determine MCP-I and CD16. White blood cell count and C-reactive protein (CRP) were determined.Results: There was a highly significant rise in CRP blood level postoperatively when compared with pre-operative blood level (p<0.001). In addition, the results revealed a significant rise in neutrophil count after operation in comparison with its baseline level before operation (p<0.001), while the level of lymphocytes showed significant decline following operation (p<0.001). The level of monocyte and eosinophil also got significantly reduced after operation (p<0.001), whereas the level of basophil showed no significant alteration after operation (p=0.687). CD16 NK cell count revealed a significant rise during the time of anesthesia. However, it showed a significant decrease postoperatively, but the reduction did not reach baseline count. It has been noticed also that the level of MCP-1 got raised significantly in association with anesthesia induction; however, it returned back to its baseline level following surgery.Conclusions: Analysis of data to correlate the innate immune components TNFα, IFNγ, MCP-I, and CD16 with types of anesthetic drugs (general, local, and regional anesthesia) showed no significant association between these components and type of anesthesia (p>0.05).

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Section: Discussionsupporting

confidence: 92%

Effects of Anesthesia on Innate Immune Components in Orthopedic Surgery

Aubaid

Yassen

2018

Asian J Pharm Clin Res

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“…These findings may not only question the benefit of RA but also alert to the potential harmful effects from using RA for bladder cancer surgery. Compared with patients undergoing TURBT who require minimal postoperative pain control with opioids, it is conceivable that the use of regional anesthesia or analgesia cannot completely obliterate the use of opioids because of the extent of surgery in those receiving radical cystectomy (47). Taking into account the finding of a dose-dependent opioid suppression of the human cellular immune system from a previous study (48), the use of opioids in patients undergoing radical cystectomy may partly explain the lack of significant beneficial impact of RA on their long-term prognosis.…”

Section: Discussionmentioning

confidence: 99%

Association of regional anesthesia with oncological outcomes in patients receiving surgery for bladder cancer: A meta-analysis of observational studies

Illias

Yu²,

Wu³

et al. 2023

Front. Oncol.

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BackgroundThis meta-analysis was conducted to compare cancer recurrence and survival rates in patients with bladder cancer receiving surgery under general anesthesia alone (i.e., GA group) or regional anesthesia (RA) with or without GA (i.e., RA ± GA group).MethodsLiterature search on Cochrane library, EMBASE, Google scholar, and Medline databases was performed to identify all relevant studies from inception to April 30, 2022. The primary outcome was cancer recurrence rate, while the secondary outcomes included overall survival rate and cancer-specific survival rate. Subgroup analyses were performed based on study design [(Propensity-score matching (PSM) vs. no-PSM)] and type of surgery [transurethral resection of bladder tumor (TURBT) vs. radical cystectomy].ResultsTen retrospective studies with a total of 13,218 patients (RA ± GA group n=4,884, GA group n=8,334) were included. There was no difference between RA ± GA group and GA group in age, the proportion of males, severe comorbidities, the proportion of patients receiving chemotherapy, and the pathological findings (all p >0.05). Patients in the RA ± GA group had significantly lower rate of bladder cancer recurrence [odds ratio (OR): 0.74, 95%CI: 0.61 to 0.9, p=0.003, I2 = 24%, six studies] compared to those in the GA group. Subgroup analyses based on study design revealed a consistent finding, while the beneficial effect of RA ± GA on reducing cancer recurrence was only significant in patients receiving TURBT (p=0.02), but not in those undergoing radical cystectomy (p=0.16). There were no significant differences in overall survival rate and cancer-specific survival rate between RA ± GA and GA groups.ConclusionsFor patients receiving surgery for bladder cancer, the application of regional anesthesia with or without general anesthesia is associated with significant decrease in cancer recurrence, especially in patients undergoing TURBT for non-muscle invasive bladder cancer. Because of the limited number of studies included and potential confounding factors, our results should be interpreted carefully.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42022328134.

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Pathophysiologie des Palliativpatienten

Hanekop

2019

Palliative Viszeralchirurgie

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Comparing the Effects of Combined General/Epidural Anaesthesia and General Anaesthesia on Serum Cytokine Levels in Radical Cystectomy

Cited by 5 publications

References 23 publications

Effects of Anesthesia on Innate Immune Components in Orthopedic Surgery

Effects of Anesthesia on Innate Immune Components in Orthopedic Surgery

Association of regional anesthesia with oncological outcomes in patients receiving surgery for bladder cancer: A meta-analysis of observational studies

Pathophysiologie des Palliativpatienten

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