The effects of endocrine disrupting chemicals on the ovary

Borgeest, Christina; Greenfeld, Chuck; Tomic, Dragana; Flaws, Jodi A.

doi:10.2741/borgees

Cited by 39 publications

(18 citation statements)

References 36 publications

(62 reference statements)

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“…Although limited information is available on the effects of pesticides on the human ovary (Figure 1), animal studies have indicated that organochlorine pesticides adversely affect the ovary by reducing ovarian weight, follicle growth, and oocyte viability and/or or increasing atresia (Figure 2) (Borgeest et al 2002; Tiemann 2008). For example, methoxychlor (32 – 200 mg/kg/day) decreased ovarian weight, increased the incidence of cystic ovaries, inhibited follicle growth, and induced atresia in rodents (Aoyama and Chapin 2014; Aoyama et al 2012; Basavarajappa et al 2012; Borgeest et al 2004; Gupta et al 2007; Gupta et al 2009; Miller et al 2005; Paulose et al 2011; Paulose et al 2012).…”

Section: Pesticidesmentioning

confidence: 99%

Exposure to endocrine disruptors during adulthood: consequences for female fertility

Rattan

Zhou

Chiang

et al. 2017

Journal of Endocrinology

259

150

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Endocrine disrupting chemicals are ubiquitous chemicals that exhibit endocrine disrupting properties in both humans and animals. Female reproduction is an important process, which is regulated by hormones and is susceptible to the effects of exposure to endocrine disrupting chemicals. Disruptions in female reproductive functions by endocrine disrupting chemicals may result in subfertility, infertility, improper hormone production, estrous and menstrual cycle abnormalities, anovulation, and early reproductive senescence. This review summarizes the effects of a variety of synthetic endocrine disrupting chemicals during adult life. The chemicals covered in this review are pesticides (organochlorines, organophosphates, carbamates, pyrethroids, and triazines), heavy metals (arsenic, lead, and mercury), diethylstilbesterol, plasticizer alternatives (di-(2-ethylhexyl) phthalate and bisphenol A alternatives), 2,3,7,8-tetrachlorodibenzo-p-dioxin, nonylphenol, polychlorinated biphenyls, triclosan, and parabens. This review focuses on the hypothalamus, pituitary, ovary, and uterus because together they regulate normal female fertility and the onset of reproductive senescence. The literature shows that several endocrine disrupting chemicals have endocrine disrupting abilities in females during adult life, causing fertility abnormalities in both humans and animals.

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Section: Pesticidesmentioning

confidence: 99%

Exposure to endocrine disruptors during adulthood: consequences for female fertility

Rattan

Zhou

Chiang

et al. 2017

Journal of Endocrinology

259

150

View full text Add to dashboard Cite

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“…Darüber hinaus gibt es Chemikalien, die das endokrine System beeinflussen. Sie imitieren, verstärken oder verringern die Wirkung von endogenen Hormonen und können so zur Apoptoseinduktion im Ovar führen [7]. So konnte z.…”

Section: Umwelteinflüsseunclassified

Ovarielle Reserve und Fertilitätserhalt

Maltaris

Αγοραστός

Beckmann

et al. 2010

Gynäkologische Endokrinologie

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Section: Umwelteinflüsseunclassified

Gonadentoxizität

et al. 2008

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LeitthemaDie grundlegende reproduktive Einheit besteht bei jeder Art aus der Mutter, dem Vater und dem Kind. Der Fortbestand einer Art ist nur gewähr-leistet, wenn dabei die Möglichkeiten der Reproduktion vollständig ausgenützt werden können. Auch das persönliche Schicksal für jedes Individuum ungewollt kinderlos zu bleiben, sollte hierbei nicht außer Acht gelassen werden. Ein vorzeitiger Verlust der Keimzellen führt zurzeit zu einer endgültigen Sterilität. In diesem Übersichtsartikel werden die Gründe für einen vorzeitigen Verlust der Keimzellen bei Frauen und Män-nern aufgezeigt sowie Möglichkeiten des Fertilitätserhaltes vor dem endgültigen Verlust der Keimzellen beschrieben.

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The effects of endocrine disrupting chemicals on the ovary

Cited by 39 publications

References 36 publications

Exposure to endocrine disruptors during adulthood: consequences for female fertility

Exposure to endocrine disruptors during adulthood: consequences for female fertility

Ovarielle Reserve und Fertilitätserhalt

Gonadentoxizität

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