The effects of elevating γ-amino butyrate content in the substantia nigra on the behaviour of rats

Hypolocomotion in rats with chronic liver failure is due to increased glutamate and activation of metabotropic glutamate receptors in substantia nigra

“…Activating glutamate receptors or blocking GABA receptors induces hypolocomotion in normal rats [18][19][20]. Glutamate receptor antagonists or GABA receptor agonists administered in SNr induce hyperlocomotion [20][21][22][23]. Alterations in glutamatergic and/or GABAergic neurotransmission in SNr may therefore contribute to the psychomotor slowing and hypokinesia in HE.…”

Effects of intracerebral injection with muscimol on locomotor activity and catalepsy in rats

“…Recently, studies have been published concerning the relationship between brain GABA function and behaviour, for example, GABA elevation in nigra induced hyperactivity (1), and pallidal GABA elevation induced akinesia (2). In addition to these two areas, the nucleus accumbens (AC), caudate nucleus (CD), and amygdaloid nucleus (AM) also contain a high concentration of GABA and/or glutamate decarboxylase (3)(4)(5).…”