The effects of dopaminergic drugs in the dorsal hippocampus of mice in the nicotine-induced anxiogenic-like response

Nasehi, Mohammad; Mafi, Fatemeh; Oryan, Shahrbanoo; Nasri, Sima; Zarrindast, Mohammad Reza

doi:10.1016/j.pbb.2011.02.011

Cited by 26 publications

(19 citation statements)

References 59 publications

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“…An increase in dopaminergic transmission has been demonstrated to aggravate anxiety [34], and the D 1 receptor antagonist SCH23390 exhibits clear anxiolytic-like effects [33, 35, 36]. However, D 2 receptor ligands can produce either anxiogenic [33, 37] or anxiolytic-like effects in animal models [28, 38, 39].…”

Section: Discussionmentioning

confidence: 99%

Levo-Tetrahydroberberrubine Produces Anxiolytic-Like Effects in Mice through the 5-HT1A Receptor

Mi¹,

Liu²,

Zhang

et al. 2017

PLoS ONE

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Tetrahydroprotoberberines (THPBs) are isoquinoline alkaloids isolated from the Chinese herb Corydalis yanhusuo. In the present study, we performed competitive binding assays to examine the binding of l-THBr to neurotransmitter receptors known to be involved in sedation, hypnosis and anxiety. Our results show that l-THBr does not interact with GABAergic receptors but has binding affinities for dopamine and serotonin receptors. In addition, cAMP and [35S]GTPγS assays were used to determine the agonist or antagonist properties of l-THBr at dopamine (D1, D2) or serotonin (5-HT) receptors. Our results show that l-THBr displays D1 and D2 antagonist and 5-HT1A agonist properties. Moreover, l-THBr-treated rodents exhibit anxiolytic-like effects in the light/dark box and elevated plus-maze tests, and the anxiolytic effect of l-THBr can be reduced by WAY-100635, a selective 5-HT1A receptor antagonist. Our results suggest that l-THBr may produce potent anxiolytic-like effects mainly through serotonin receptors.

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Section: Discussionmentioning

confidence: 99%

Levo-Tetrahydroberberrubine Produces Anxiolytic-Like Effects in Mice through the 5-HT1A Receptor

Mi¹,

Liu²,

Zhang

et al. 2017

PLoS ONE

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“…Between EPM sessions and after each rat the maze was cleaned with distilled water. The obtained data were used to calculate: a) % OAT (the ratio of time spent in open arms to the time spent in all arms ×100); b) % OAE (the ratio of entries into open arms to total entries ×100) [55,97,98], and c) the total closed and open arm entries were considered as a relatively pure index for the locomotor activity [93,95].…”

Section: Behavioural Testingmentioning

confidence: 99%

“…Dopamine exerts its effect via two different dopamine subtypes receptors, called the D 1 -and D 2 -like families [55]. These two dopamine family receptors have a high expression in both parts of NAc while at different distribution patterns.…”

Section: Introductionmentioning

confidence: 99%

Original article Involvement of D 2 /D 2 dopamine antagonists upon open-arms exploratory behaviours induced by intra-nucleus accumbens shell administration of N-methyl-D-aspartate

Razavi¹,

Haeri-Rohani²,

Eidi³

et al. 2014

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“…The percentage open arm entries as well as the open arm time percentage (as standard anxiety-like behavior indices) were calculated as follows: (a) % OAT (the ratio of time spent in open arms to total time spent in any arm×100); (b) %OAE (the ratio of entries into open arms to total entries×100) (Zarrindast, Torabi et al, 2006;Zarrindast, Valizadegan et al, 2008;Nasehi, Mafi et al, 2011). (c) Total closed and open arm entries were considered as a relatively pure index of locomotor activity (Zarrindast, Solati et al, 2008;.…”

Section: Behavioral Test (Elevated Plus-maze)mentioning

confidence: 99%

“…There are different investigations indicating neurobiology of anxiety and drugs that induced anxiety-like behaviors in different brain regions (Zarrindast, Nasehi et al, 2010;Nasehi, Mafi et al, 2011;. Although, traditionally, the NAc shell has been considered a region involved in defensive and anxiety-like behaviors (Martinez, Ropero et al, 2002;Avena, Rada et al, 2008); (Pliakas, Carlson et al, 2001); (Reynolds and Berridge 2003) (da Cunha, Lopes et al, 2008), locomotion (Gargiulo 1996) (Martinez, Ropero et al, 2002) and depression (Shirayama and Chaki 2006).…”

Section: Introductionmentioning

confidence: 99%

Interaction of GABA (A) system in the nucleus accumbens ahell with ACPA on anxiety-like behaviors in Wistar male rat

Zarrindast¹,

Ahmadi²,

Nasehi³

2013

J. Exper. Appl. Anim. Sci.

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It has been recently reported that cannabinoid and GABA systems in the nucleus accumbens (NAc) are involved in anxiety-related behaviors. Thus the purpose of the present study is to investigate the involvement of ACPA interaction with GABA-ergic of the NAc shell in anxiolytic-like behaviors in Wistar male rat. The elevated plus maze apparatus has been used to test parameters of anxiety-like behaviors. The data demonstrated that bilateral injection of GABA (A) receptor agonist (Muscimol 0.4 μg/μl) increased % OAT. Furthermore, injection of GABA (A) receptor antagonist (Bicuculline 0.9μg/μl) increased locomotor activity. The data indicated anxiolytic-like behaviors caused by the Muscimol injection into the NAc shell. Moreover, bilateral injection of ACPA (CB1 -selective agonists; 0.025μg/μl) into the NAc shell induced anxiogenic-like behaviors. The final results showed that intra-NAc shell injection of subthreshold dose of Muscimol (0.2 μg/μl) attenuated anxiogenic-like behaviors by higher dose (0.025 μg/μl) of ACPA in the NAc shell. In addition, intra-NAc shell injection of subthreshold dose of Bicuculline (0.6 μg/μl) did not alter anxiogenic response by ACPA administration in the NAc shell. The results suggested that the activation of the NAc shell GABA (A) receptor attenuated the activity of cannabinoid system in the NAc shell.

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The effects of dopaminergic drugs in the dorsal hippocampus of mice in the nicotine-induced anxiogenic-like response

Cited by 26 publications

References 59 publications

Levo-Tetrahydroberberrubine Produces Anxiolytic-Like Effects in Mice through the 5-HT1A Receptor

Levo-Tetrahydroberberrubine Produces Anxiolytic-Like Effects in Mice through the 5-HT1A Receptor

Original article Involvement of D 2 /D 2 dopamine antagonists upon open-arms exploratory behaviours induced by intra-nucleus accumbens shell administration of N-methyl-D-aspartate

Interaction of GABA (A) system in the nucleus accumbens ahell with ACPA on anxiety-like behaviors in Wistar male rat

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