The Effects of distilled Wild Ginseng Herbal Acupuncture on the Heart Rate Variability(HRV)

Roh, Jeong Du; Kim, Lakhyung; Song, Beomyong; Yook, Tae-Han

doi:10.3831/kpi.2008.11.1.055

Cited by 10 publications

(3 citation statements)

References 16 publications

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“…However, immune protein, which acts against microbes and pathogenic organisms, vitamin D binding protein, which protects the lung at the time of inflammatory response, ras-related protein Ral-A, which controls phospholipid metabolism, cytoskeletal formation, and membrane traffic, and transferrin which balances the iron level in the body were reported to be increased significantly, after the administration of MGP, but antitrypsin, which is secreted with inflammatory responses in the lungs, were reduced [13, 14]. Also no effects on heart rate variability [15] and pulse-wave factors were revealed in middle-aged women [16]. …”

Section: Discussionmentioning

confidence: 99%

Intravenous Single-dose Toxicity of Mountain Ginseng Pharmacopuncture in Sprague-Dawley Rats

Lee¹,

Sun²,

Yu³

et al. 2014

Journal of Pharmacopuncture

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Objectives:Mountain ginseng pharmacopuncture (MGP) is an extract distilled from either mountain cultivated ginseng or mountain wild ginseng. This is the first intravenous injection of pharmacopuncture in Korea. The word intravenous does not discriminate between arteries, veins, and capillaries in Oriental Medicine, but only the vein is used for MGP. The aim of this study is to evaluate the intravenous injection toxicity of MGP through a single-dose test in Sprague-Dawley (SD) rats.Methods:Male and female 6-week-old SD rats were injected intravenously with MGP (high dosage of 20 mL/kg or low dosage of 10 mL/kg). Normal saline was injected into the rats in the control group by using the same method. After the rats has treated, we conducted clinical observations, body-weight measurements and histological observations.Results:In this study, no mortalities were observed in any of the experimental groups. Also, no significant changes by the intravenous injection of MGP were observed in the body weights, or the histological observations in any of the experimental groups compared to the control group. The lethal dose for intravenous injection of MGP was found to be over 20 mL/kg in SD rats.Conclusion:Considering that the dosage of MGP generally used each time in clinical practice is about 0.3 mL/kg, we concluded with confidence that MGP is safe pharmacopuncture.

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Section: Discussionmentioning

confidence: 99%

Intravenous Single-dose Toxicity of Mountain Ginseng Pharmacopuncture in Sprague-Dawley Rats

Lee¹,

Sun²,

Yu³

et al. 2014

Journal of Pharmacopuncture

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“…By contrast, randomized controlled trials (RCTs) showed that the sympathetic nervous system in healthy participants was activated significantly by wild ginseng pharmacopuncture injected at acupoints as compared with saline injection [22][23][24][25]. Intravenous wild ginseng pharmacopuncture decreased the mean heart rate variability (HRV) and pulse wave velocity (PWV) and increased the mean and standard deviation of normal R-R intervals and very low frequency oscillation power in patients with breast cancer [26], while it decreased the mean HRV and PWV and increased the mean normal R-R intervals in healthy volunteers [27].…”

Section: Physiological Response To Ginseng Pharmacopuncture In Human mentioning

confidence: 93%

Panax ginseng Pharmacopuncture: Current Status of the Research and Future Challenges

2019

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Despite the increasing use of ginseng pharmacopuncture in clinical practice, evidence of its physiological effects, safety, and clinical outcomes is insufficient. The purpose of this review is to summarize previous studies and suggest future challenges for the clinical use of ginseng pharmacopuncture. We systematically searched clinical and animal studies that applied ginseng pharmacopuncture and reviewed the manufacturing processes of ginseng pharmacopuncture solution, safety, physiological responses, and clinical effects. Intravenous or point injection of the ginseng pharmacopuncture solution made by distillation extraction has been commonly used in studies. Ginseng pharmacopuncture does not show any toxicity in animals and humans, while it influenced the heart rate variability, pulse wave velocity, and protein synthesis in human subjects. In 25 case reports, patients with cancer, amyotrophic lateral sclerosis, skin wrinkles, and allergic rhinitis showed significant improvement of clinical outcomes. We found that more evidence is necessary to conclude that ginseng pharmacopuncture is safe and effective. First, the pharmacopuncture manufacturing process should be standardized on the basis of the safety and efficacy tests. Moreover, studies on the quantitative quality of the components of the solution and on the clinical comparison of various injection methods are required to improve clinical outcomes in the future.

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“…지금까지 산양산삼을 이용한 연구는 주로 약침학 분야에서 이루어져 왔다. 산양산삼의 약침제제는 항독성 및 항암작용 [8][9][10][11] , 암세포의 apoptosis 유도 12) , 혈당강하 작용 13) , 지질강 하 및 항산화효과 [14][15][16] , 인체혈액내의 단백질변화 17) , 지방세포 분화 억제 18) , 자율신경계 조절 19) , 간기능 개선효과 20) , 근위축 성 측삭 경화증 개선 21) , 자가치료능 22 Table 4).…”

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Mountain cultivated ginseng water boiled extract decreases blood glucose level and improves lipid metabolism in male db/db mice

Kim¹,

Kim²,

Lee³

et al. 2012

The Korea Journal of Herbology

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Objectives：We investigated the effects of mountain cultivated ginseng water boiled extract(MCG) on blood glucose and insulin levels, and examined whether lipid metabolism are improved by it in male db/db mice(a murine model of type 2 diabetes mellitus). Methods：9 weeks old, male db/db mice were divided into 5 groups： C57BL/6J normal, control, MCG-250㎎/㎏ (MCG-1), MCG-500㎎/㎏(MCG-2) and MCG-1000㎎/㎏(MCG-3). After mice were treated with MCG for 8 weeks, we measured body weight, food intake, fat weight, visceral organ weight and blood glucose, insulin and lipid levels. Results：1. We found no difference in body weight, food intake, fat weight and visceral organ weight among the animal groups. 2. Compared with controls, MCG-treated mice had lower blood glucose level and higher blood insulin levels, the magnitude of which was prominent in MCG-2. 3. Compared with controls, MCG-treated mice had lower LDL-cholesterol and higher HDL-cholesterol levels. 4. Compared with controls, MCG-treated mice had blood triglyceride and free fatty acid levels, the magnitude of which was prominent in MCG-2. 5. Blood AST and ALT concentrations were not changed by MCG, indicating MCG do not show any toxic effects.Conclusions：These results demonstrate that MCG effectively increases blood insulin level and decreases blood glucose level, blood lipid levels, and prevents and improves diabetic dyslipidemia and cardiovascular disease.

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The Effects of distilled Wild Ginseng Herbal Acupuncture on the Heart Rate Variability(HRV)

Cited by 10 publications

References 16 publications

Intravenous Single-dose Toxicity of Mountain Ginseng Pharmacopuncture in Sprague-Dawley Rats

Intravenous Single-dose Toxicity of Mountain Ginseng Pharmacopuncture in Sprague-Dawley Rats

Panax ginseng Pharmacopuncture: Current Status of the Research and Future Challenges

Mountain cultivated ginseng water boiled extract decreases blood glucose level and improves lipid metabolism in male db/db mice

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