The effects of dietary ω-3 polyunsaturated fatty acids on erythrocyte membrane phospholipids, erythrocyte deformability and blood viscosity in healthy volunteers

Cartwright, Ian J.; Pockley, A. Graham; Galloway, J. H.; Greaves, M.; Preston, F. E.

doi:10.1016/0021-9150(85)90106-6

Cited by 218 publications

(84 citation statements)

References 31 publications

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“…Fatty acid compositions in phospholipids of the RBC were noticeably reflected in dietary fatty acid. It has been reported that daily supplement of ethylester of EPA (8) and fish oil concentrate (9) increased n-3 PUFA in the RBC and led to an increase in RBC deformability (8,9), but in our study, the RBC deformability assessed by the passing time through microchannels was not significantly different in the two groups.…”

Section: Discussioncontrasting

confidence: 87%

“…It seems that the RBC deformability is apt to be varied by the fatty acid composition of the RBC membrane. RBC deformability was improved by the intake of n-3 PUFAs, such as EPA or DHA (8)(9)(10)(11)(12). On the other hand, it has also been reported that the intake of PUFA did not change the deformability (13)(14)(15)(16).…”

Section: Ma and Myocardial Infarction (4-7)mentioning

confidence: 99%

“…These contradictory results were caused not only by differences in the intake level of n-3 PUFAs but also by differences in the assessment of RBC deformability. Conventionally, the nickel mesh filtration method (8)(9)(10)(11)(12)(13) and the rheoscope method (14) have been used, but they did not have the same accurate interstice gages. To solve the problem, a Micro Channel Array Flow Analyzer (MC-FAN) equipped with a siliconized microchannel array as a capillary vessel model has been developed by Kikuchi et al (17,18).…”

Section: Ma and Myocardial Infarction (4-7)mentioning

confidence: 99%

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Effect of Dietary Supplementation of n-3 Polyunsaturated Fatty Acids (PUFA) on Red Blood Cell Deformability and Blood Viscosity in Rats

et al. 2003

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Section: Discussioncontrasting

confidence: 87%

Section: Ma and Myocardial Infarction (4-7)mentioning

confidence: 99%

Section: Ma and Myocardial Infarction (4-7)mentioning

confidence: 99%

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Effect of Dietary Supplementation of n-3 Polyunsaturated Fatty Acids (PUFA) on Red Blood Cell Deformability and Blood Viscosity in Rats

et al. 2003

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“…In addition, the results showing the modi®cation in the fatty acid composition of erythrocyte membranes are a better marker of n-3 PUFA incorporation in the tissues than changes in the composition of plasma. In erythrocytes, these modi®cations can induce changes in eicosanoid formation as well as enhanced deformability and reduced blood viscosity (Cartwright et al, 1985), which are bene®cial effects in cardiovascular diseases. In the present study, concentrations of DHA were not so greatly affected by ®sh oil ingestion as were those of EPA, in both plasma and erythrocytes.…”

Section: Discussionmentioning

confidence: 99%

Administration of low doses of fish oil derived N-3 fatty acids to elderly subjects

et al. 1997

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Objectives: To assess the incorporation of n-3 polyunsaturated fatty acids (PUFA) in plasma and erythrocyte lipids of elderly subjects after ingestion of very low doses of ®sh oil. The effects on a-tocopherol and retinol concentrations were also studied. Setting: Municipal nursing home in Barcelona, Spain. Subjects: Forty-®ve elderly subjects aged 60±92 y. Design and intervention: Subjects received a non-commercialized milk formula containing 1% ®sh oil for 15 months, which provided 0.40 g/d of n-3 PUFA. Fatty acid pro®les and antioxidant concentrations were measured before and after the intervention period. Results: Fish oil ingestion was associated with signi®cant increases in total n-3 PUFA in plasma and erythrocytes by 32% and 18%, respectively. Eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid concentrations were higher after the ingestion period both in plasma and erythrocytes (P`0.05), whereas linoleic and arachidonic acids remained unchanged. The n-6/n-3 ratio decreased by 21% in plasma and by 16% in erythrocytes (P`0.05). Moreover, younger subjects showed a greater incorporation of EPA and DHA than older subjects. Plasma a-tocopherol and retinol concentrations did not vary signi®cantly, whereas erythrocyte atocopherol was signi®cantly higher after the intervention period. Conclusion: This study shows that low doses of n-3 PUFA supplemented with adequate amounts of a-tocopherol can be incorporated into blood lipids in elderly subjects without lowering their antioxidant concentrations. Sponsorship: This study was supported by a research grant from the Spanish CDTI.

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“…These reductions in RBC deformability have been attributed to an increased peroxidation of lipid membranes resulting from exercise-induced free radical production [74]. A number of studies suggest that n-3 derivatives help to increase the deformability of RBCs [11,76] which would theoretically heighten oxygen and nutrient delivery to exercising muscles and thereby enhance performance. …”

Section: Theoretical Basis For N-3 Supplementation In Combination Witmentioning

confidence: 99%

Omega-3 fatty acids and exercise: a review of their combined effects on body composition and physical performance

Tiryaki-Sönmez

Schöenfeld

Vatansever-Ozen

2011

Biomedical Human Kinetics

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SummaryOmega-3 (n-3) fatty acids, and the long-chain n-3 derivatives eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in particular, have been extensively researched for their nutritive effects. Among their many purported benefits, n-3 acids have been implicated as positive mediators of cardiovascular health and body composition. It has therefore been speculated that supplementation may enhance the beneficial effects of physical activity, potentiating greater reductions in body fat and improvements in exercise performance. This paper has three objectives: first, to assess the theoretical basis for a synergistic ef-fect when n-3 supplementation is combined with exercise; second, to review the literature as to specific findings on the subject and third, to make relevant conclusions and recommendations for future research.

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The effects of dietary ω-3 polyunsaturated fatty acids on erythrocyte membrane phospholipids, erythrocyte deformability and blood viscosity in healthy volunteers

Cited by 218 publications

References 31 publications

Effect of Dietary Supplementation of n-3 Polyunsaturated Fatty Acids (PUFA) on Red Blood Cell Deformability and Blood Viscosity in Rats

Effect of Dietary Supplementation of n-3 Polyunsaturated Fatty Acids (PUFA) on Red Blood Cell Deformability and Blood Viscosity in Rats

Administration of low doses of fish oil derived N-3 fatty acids to elderly subjects

Omega-3 fatty acids and exercise: a review of their combined effects on body composition and physical performance

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