Administration of low doses of fish oil derived N-3 fatty acids to elderly subjects

Rodrı́guez-Palmero, Marı́a; López-Sabater, M. Carmen; Castellote-Bargallo, AI; Torre-Boronat, MC de la; Rivero-Urgell, M.

doi:10.1038/sj.ejcn.1600445

Cited by 18 publications

(5 citation statements)

References 25 publications

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“…our cohort) were among the lowest. A similar construct for serum or plasma total long chain n-3 PUFA is presented in Figure 2, where the spread is not nearly as great[11-13,26-28]. Here as well, hemodialysis patients had in general lower levels than non-dialysis patients, with U.S. patients having the lowest mean levels overall.…”

Section: Resultsmentioning

confidence: 75%

Low Blood Levels of Long-Chain n–3 Polyunsaturated Fatty Acids in US Hemodialysis Patients: Clinical Implications

Friedman

Yu²,

Tabbey

et al. 2012

Am J Nephrol

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Background: Cardioprotective and other clinical benefits of long-chain n–3 polyunsaturated fatty acids (PUFA) are inversely related to dietary intake and hence blood content. We therefore investigated, in the first study of its kind, the blood content and distribution of these fatty acids in a large representative population of US hemodialysis patients. Methods: Frozen sera were obtained from 400 individuals who were part of a large, contemporary, representative cohort of US incident hemodialysis patients. Long-chain n–3 PUFA were measured in total serum lipids and in the neutral and polar serum fractions using gas chromatography and solid phase extraction techniques. Mean long-chain n–3 PUFA levels were compared to levels in other dialysis and nondialysis populations from published reports. Results: The study population was qualitatively similar to the overall US hemodialysis population in terms of major clinical characteristics. Long-chain n–3 PUFA were present in the serum polar fraction, with essentially none being detected in the neutral fraction (p < 0.0001 for polar vs. neutral fractions for all three long-chain n–3 PUFA). Mean serum long-chain n–3 PUFA levels (weight percent (±SD): total 1.55 ± 0.95, polar 3.99 ± 1.45) were low compared to nondialysis and most other non-US hemodialysis cohorts. Conclusions: While US hemodialysis patients have a blood distribution of long-chain n–3 PUFA that is similar to that in the general population, blood content is among the lowest recorded in the medical literature. This has implications for renal dietary recommendations and makes US patients an ideal group for testing the clinical effects of long-chain n–3 PUFA supplementation.

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Section: Resultsmentioning

confidence: 75%

Low Blood Levels of Long-Chain n–3 Polyunsaturated Fatty Acids in US Hemodialysis Patients: Clinical Implications

Friedman

Yu²,

Tabbey

et al. 2012

Am J Nephrol

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“…Indeed, it is commonly said that the erythrocyte fatty acid composition is more representative than plasma for the long-term dietary intake in lipids [51], [65], [66], due to a life span of approximately 120 days [67]. Fatty acid composition of erythrocytes was used in a few number of human studies, particularly to assess the incorporation of dietary lipids into the blood compartment, and their bioavailability to peripheral tissues [4], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77]. Among them, a study of Makrides and collaborators has examined the fatty compositions of the brain, the retina, and the erythrocytes from post-mortem infants [4].…”

Section: Discussionmentioning

confidence: 99%

Lipid Composition of the Human Eye: Are Red Blood Cells a Good Mirror of Retinal and Optic Nerve Fatty Acids?

et al. 2012

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BackgroundThe assessment of blood lipids is very frequent in clinical research as it is assumed to reflect the lipid composition of peripheral tissues. Even well accepted such relationships have never been clearly established. This is particularly true in ophthalmology where the use of blood lipids has become very common following recent data linking lipid intake to ocular health and disease. In the present study, we wanted to determine in humans whether a lipidomic approach based on red blood cells could reveal associations between circulating and tissue lipid profiles. To check if the analytical sensitivity may be of importance in such analyses, we have used a double approach for lipidomics.Methodology and Principal FindingsRed blood cells, retinas and optic nerves were collected from 9 human donors. The lipidomic analyses on tissues consisted in gas chromatography and liquid chromatography coupled to an electrospray ionization source-mass spectrometer (LC-ESI-MS). Gas chromatography did not reveal any relevant association between circulating and ocular fatty acids except for arachidonic acid whose circulating amounts were positively associated with its levels in the retina and in the optic nerve. In contrast, several significant associations emerged from LC-ESI-MS analyses. Particularly, lipid entities in red blood cells were positively or negatively associated with representative pools of retinal docosahexaenoic acid (DHA), retinal very-long chain polyunsaturated fatty acids (VLC-PUFA) or optic nerve plasmalogens.Conclusions and SignificanceLC-ESI-MS is more appropriate than gas chromatography for lipidomics on red blood cells, and further extrapolation to ocular lipids. The several individual lipid species we have identified are good candidates to represent circulating biomarkers of ocular lipids. However, further investigation is needed before considering them as indexes of disease risk and before using them in clinical studies on optic nerve neuropathies or retinal diseases displaying photoreceptors degeneration.

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“…This increase in PUFA content is rather unusual when compared with data from other studies which report small increases in PUFA following DHA supplementation in the form of triacylglycerols. For example, Vidgren et al (1997) reported a 1 % increase after 14 weeks, and Rodriguez-Palmero et al (1997) reported a 2 % increase after 15 months. Small decreases, even, have been noted by Nelson et al (1997) (4 % after 90 d) and by Wensing et al (1999) (3 % after 6 weeks).…”

Section: Discussionmentioning

confidence: 99%

“…Docosahexaenoic acid (DHA) v. DHA:arachidonic acid (AA) ratio in erythrocyte membrane lipids. The various values represent the data of: the present study at 0 months and 9 months and that of a control group of young healthy individuals (C2); elderly and supplemented elderly subjects (Rodriguez-Palmero et al 1997); insulin-dependent diabetes mellitus (IDDM), insulin-dependent diabetes mellitus (NIDDM) and control subjects (C3) (Horrobin, 1997); depressive patients and control subjects (C4) (Peet et al 1998); schizophrenia patients and control subjects (C1) (Laugharne et al 1996).…”

Section: Discussionmentioning

confidence: 99%

Docosahexaenoic acid-enriched egg consumption induces accretion of arachidonic acid in erythrocytes of elderly patients

Payet

Esmail

Polichetti³

et al. 2004

Br J Nutr

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Many studies in humans volunteers have shown that dietary docosahexaenoic acid (DHA) supplied as triacylglycerol can increase DHA levels in blood lipids but often strongly decreases those of arachidonic acid (AA). The aim of the present study was to determine the effect of dietary supplementation with egg-yolk powder enriched in DHA, corresponding to the French recommended dietary allowance for DHA, on the blood lipid status of an elderly population. Institutionalised elderly individuals aged between 63 and 93 years consumed an egg product enriched in DHA (150 mg/d) once daily for 9 months. Plasma lipids and the fatty acid composition of erythrocyte membranes were determined every 3 months. The supplementation induced an increase in the PUFA content of plasma and erythrocyte membranes which was þ 14·5 and þ25·3 %, respectively, at 9 months. This effect was mainly due to the level of DHA and, unexpectedly, to that of AA which continuously increased. This increase in AA was the result of an increased dietary intake (þ50 mg/d) and very probably of an increased biosynthesis as demonstrated by the behaviour of di-homo-g-linolenic acid. The supplementation resulted in a blood PUFA status comparable with that of young healthy controls. The data are consistent with a strong regulatory action of the dietary treatment on the subjects' lipid metabolism.

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Administration of low doses of fish oil derived N-3 fatty acids to elderly subjects

Cited by 18 publications

References 25 publications

Low Blood Levels of Long-Chain n–3 Polyunsaturated Fatty Acids in US Hemodialysis Patients: Clinical Implications

Low Blood Levels of Long-Chain n–3 Polyunsaturated Fatty Acids in US Hemodialysis Patients: Clinical Implications

Lipid Composition of the Human Eye: Are Red Blood Cells a Good Mirror of Retinal and Optic Nerve Fatty Acids?

Docosahexaenoic acid-enriched egg consumption induces accretion of arachidonic acid in erythrocytes of elderly patients

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