Docosahexaenoic acid-enriched egg consumption induces accretion of arachidonic acid in erythrocytes of elderly patients

Payet, M.; Esmail, Mohamed H.; Polichetti, Elisabeth; Brun, Gaël Le; Adjemout, Lounès; Donnarel, G; Portugal, Henri; Piéroni, G

doi:10.1079/bjn20041106

Cited by 23 publications

(11 citation statements)

References 34 publications

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“…Furthermore, a certain level of serum DHA is modifiable through the consumption of fish or dietary supplements in DHA. 46 Recently, red blood cell levels of DHA plus EPA were reported to be explained by DHA plus EPA intake (25%), heritability (24%) and fish oil supplementation (15%) in the Framingham Heart Study. 47 In our Japanese sample ( n =430), Pearson's correlation coefficient between serum DHA and DHA intake assessed by a 3-day dietary record was 0.18 ( P <0.01, data not shown).…”

Section: Discussionmentioning

confidence: 99%

Serum docosahexaenoic and eicosapentaenoic acid and risk of cognitive decline over 10 years among elderly Japanese

et al. 2014

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Background/Objectives:To clarify the association of serum docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) levels with cognitive decline over 10 years.Subjects/Methods:This study was part of the National Institute for Longevity Sciences - Longitudinal Study of Aging, and was conducted with 232 male and 198 female Japanese community-dwelling subjects aged 60–79 years in the second wave (2000–2002). Cognitive function was assessed with the Mini-Mental State Examination (MMSE) in both the second and seventh (2010–2012) waves. Fasting venous blood samples were collected in the morning, and serum DHA and EPA levels were measured. Multiple logistic regression analysis was performed among participants with an MMSE score ⩾24 in the second wave (n=430) to estimate the odds ratio (OR) and 95% confidence interval (CI) for MMSE score ⩽23 or MMSE score decline ⩾4 10 years later. These estimates were based on baseline tertiles of serum DHA or EPA levels, and controlled for age, sex, education, MMSE score at baseline, alcohol consumption, current smoking, body mass index and disease history.Results:Fifteen (3.5%) subjects whose MMSE score was ⩽23 and 36 (8.3%) subjects whose MMSE score declined to ⩾4 showed cognitive decline. Multivariate-adjusted OR (95% CI) for the lowest through highest tertiles of serum DHA to MMSE score ⩽23 or decline⩾4 were 1.00 (reference), 0.11 (0.02–0.58) and 0.17 (0.04–0.74), or 1.00 (reference), 0.22 (0.08–0.61) and 0.31 (0.12–0.75), respectively (P for trend=0.01 or 0.04). Serum EPA was not associated with cognitive decline.Conclusions:The study gives some indication that a moderately high level of serum DHA might prevent cognitive decline among community-dwelling elderly Japanese individuals.

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Section: Discussionmentioning

confidence: 99%

Serum docosahexaenoic and eicosapentaenoic acid and risk of cognitive decline over 10 years among elderly Japanese

et al. 2014

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“…Interestingly, following a 6 week low dose supplementation of glycerophospholipid-liposomes obtained from DHA enriched eggs (GPL-DHA), cystic fibrosis mice showed restored linoleic acid levels in intestines and lung, but not in pancreas and diminished arachidonic acid biosynthesis in all 3 organs [290]. Thus, GLP-DHA supplementation could potentially be promising for nutritherapy in cystic fibrosis patients similarly to GLP-DHA supplementation in elderly [291]. An additional study indicated improvement in lung function following 8 months of supplementation with both DHA and EPA [292].…”

Section: Abnormalities In Polyunsaturated Fatty Acid (Pufa) Turnover mentioning

confidence: 94%

Lipid Mediator Profiling in Pulmonary Disease

Lundström

Balgoma²,

Wheelock³

et al. 2011

CPB

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Oxylipins (e.g. eicosanoids) are endogenous signaling molecules that are formed from fatty acids by mono- or dioxygenase-catalyzed oxygenation and have been shown to play an important role in pathophysiological processes in the lung. These lipid mediators have been extensively studied for their role in inflammation in a broad swathe of respiratory diseases including asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis and extrinsic allergic alveolitis. Traditional efforts have employed analytical methods (e.g. radio- and enzyme-immunoassay techniques) capable of measuring a limited number of compounds simultaneously. The advent of the omics technologies is changing this approach and methods are being developed for the quantification of small molecules (i.e. metabolomics) as well as lipid-focused efforts (i.e. lipidomics). This review examines in detail the breadth of oxylipins and their biological activity in the respiratory system. In addition, the state-of-the-art methodology in profiling of oxylipins via mass spectrometry is summarized including sample work-up and data processing. These methods will greatly increase our ability to probe oxylipin biology and examine for cross-talk between biological pathways as well as specific compartments in the body. These new data will increase our insight into disease processes and have great potential to identify new biomarkers for disease diagnosis as well as novel therapeutic targets.

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“…In the present trial, the eggs, particularly Italian breed eggs, had a higher DHA content than conventional eggs (Payet et al, 2004), and therefore they seem to be an interesting vehicle to supply DHA in the form of phospholipids compared with triacylglycerols (Payet et al, 2004).…”

Section: Fatty Acid Composition Of Breast and Thigh Meat And Egg Yolkmentioning

confidence: 97%

Chemical composition of meat and egg yolk of hybrid and Italian breed hens reared using an organic production system

Rizzi

Chiericato

2010

Poultry Science

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A trial was done to study the chemical composition of meat and egg yolk of laying hens belonging to different genotypes reared using an organic production system. Two commercial hybrid hens (Hy-Line Brown and Hy-Line White 36) and 2 Italian dual-purpose breed hens (Ermellinata di Rovigo and Robusta Maculata) were reared from 25 to 44 wk of age. During the experimental period (July to December), the environmental temperature decreased from about 25 to 13 degrees C and the RH increased from 62 to 73%. The photoperiod was 16L:8D. Meat and egg yolks of 44-wk-old hens were analyzed. The Italian breeds showed higher meat production and lower egg production when compared with the hybrids. Genotype affected protein, lipid, and ash content of breast and thigh meat. Hy-Line White and Ermellinata di Rovigo showed the lowest (P<0.01) breast lipid and Hy-Line White had the lowest (P<0.01) thigh lipid. Hy-Line White showed higher (P<0.05) breast and thigh cholesterol. Genotype affected egg yolk cholesterol, which was higher (P<0.01) in Italian breeds than in hybrids. The fatty acid profiles of meat and yolk were significantly affected by genotype. The hybrid and Robusta Maculata meat and egg fatty acid composition may be considered to be more favorable to human health. The results indicate that the ability of laying hens to incorporate fatty acids is genetically dependent and a possible interaction between strain and environmental conditions may exist for the absorption and utilization of dietary components.

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Docosahexaenoic acid-enriched egg consumption induces accretion of arachidonic acid in erythrocytes of elderly patients

Cited by 23 publications

References 34 publications

Serum docosahexaenoic and eicosapentaenoic acid and risk of cognitive decline over 10 years among elderly Japanese

Serum docosahexaenoic and eicosapentaenoic acid and risk of cognitive decline over 10 years among elderly Japanese

Lipid Mediator Profiling in Pulmonary Disease

Chemical composition of meat and egg yolk of hybrid and Italian breed hens reared using an organic production system

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