The effects of cyclophosphamide alone and in combination with ascorbic acid against murine ascites Dalton′s lymphoma

Nicol, BM; Prasad, Srivatsa B.

doi:10.4103/0253-7613.27022

Cited by 14 publications

(2 citation statements)

References 22 publications

(23 reference statements)

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“…As a consequence, there is increasing desire for the development of bio-based products as alternatives. 9,10 A major benefit of utilizing bioproducts lies in their ecologically approachability and significantly reduced hazards to human consumption/ingestion in contrast to petroleum-based resources. For most lightweight, structural, and semi-structural applications, biofiber composites are mostly preferred over synthetic fiber composites owing to their highly advantageous nature.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and thermomechanical properties of bioplastics and biocomposites: a systematic review

et al. 2023

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Section: Introductionmentioning

confidence: 99%

Synthesis and thermomechanical properties of bioplastics and biocomposites: a systematic review

et al. 2023

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“…Plants maintain the health and vitality of individuals and also cure diseases, including cancer without causing toxicity. More than 50% of all modern drugs in clinical use are of natural products, many of which have the ability to control cancer cells [1]. Saraca Asoca (Roxb.…”

Section: Introductionmentioning

confidence: 99%

Anti-Cancer Effects of Saraca asoca Flower Extract on Prostate Cancer Cell Line

Choudhary

Elumalai

Subramanian

et al. 2021

JPRI

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Background: Prostate cancer is the second most common cause of cancer deaths for men. The role of plants in the prevention and treatment of disease has been known from the dawn of civilization. Plants maintain the health and vitality of individuals and also cure diseases, including cancer without causing toxicity. More than 50% of all modern drugs in clinical use are of natural products, many of which have the ability to control cancer cells. Saraca Asoca (Roxb.), De. Wild or Saraca indica is one of the most ancient trees of India Aim: Aim of this study is to investigate the anti-cancer effects of Saraca Asoca flower extract on prostate cancer cell line. Materials and Methods: The anti-cancer effects of Saraca Asoca extract on prostate cancer cell lines was assessed by cell viability assay, cell and nuclear morphological studies. The multiple concentration of Saraca Asoca extract (0, 20, 40, 60, 80, 100 and 120 µg/ml) was used and IC50 doses were calculated. Results: The MTT (3-[4,5-dimethylthiazol-2yl]-2,5-diphenyl-tetrazolium bromide) assay results showed the percentage of cell viability significantly decreased in treated cells compared to control groups without any treatment was represented as 100% and we observed inhibitory concentration was 60µg/ml. Morphologic changes observed showed cell shrinkage, and cytoplasmic membrane blebbing, were observed under phase-contrast microscope. The apoptotic nuclei (intensely stained, fragmented nuclei, and condensed chromatin) were viewed under a fluorescent microscope. Conclusion: Overall, the present study results demonstrated the cytotoxic and proapoptotic effects of Saraca Asoca flower extract on prostate cancer cell line. However, more research is needed to understand the active prinsciple compounds present in the extract and molecular mechanisms of its anti-cancer effects.

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Role of lncRNAs as prognostic markers of hepatic cancer and potential therapeutic targeting by S-adenosylmethionine via inhibiting PI3K/Akt signaling pathways

Sadek

Lebda

Nasr

et al. 2018

Environ Sci Pollut Res

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Hepatic cancer (HCC) is a well-identified dilemma throughout the world, and hence, the molecular mechanisms and strategy for preventive protection against this malignancy are critical. S-adenosylmethionine (SAM) is a unique methyl granter in vast reactions, including DNA methylation, and secures the genome against hypomethylation, which is a hallmark of tumors. Consequently, SAM may control the rate of gene expression. The objective of this investigation was to evaluate the expression of long noncoding RNAs (lncRNAs) transcript involved in hepatic tumorigenesis, including additional coding CEBPA (ecCEBPA) and urothelial carcinoma related 1 (UCA1), antioxidant enzymes transcripts, and relevant signaling pathway in diethylnitrosamine (DEN)-prompted HCC along with their conceivable targeting by SAM at different stages of HCC in rats. Our outcomes revealed that SAM particularly when given at the starting phase downregulates ecCEBPA and UCA1 gene transcripts and ameliorate histopathological alterations in DEN-initiated HCC. Interestingly, SAM attenuates DEN-induced upregulation of PI3K/Akt protein expression. However, SAM upregulates the antioxidant enzymes mRNA transcripts and effectively diminishing DNA oxidation. The results of a DNA fragmentation assay further support the capacity of SAM to ameliorate DEN-induced hepatic malignancy. These results revealed the role of ecCEBPA and UCA1 in HCC and suggest that these lncRNAs may be helpful as prognostic and analytical biomarkers of HCC. Curiously, SAM readily targets the studied genes via inhibiting PI3K/Akt signaling pathway, which should make SAM an appealing agent for both chemoprevention and treatment of HCC.

show abstract

The effects of cyclophosphamide alone and in combination with ascorbic acid against murine ascites Dalton′s lymphoma

Cited by 14 publications

References 22 publications

Synthesis and thermomechanical properties of bioplastics and biocomposites: a systematic review

Synthesis and thermomechanical properties of bioplastics and biocomposites: a systematic review

Anti-Cancer Effects of Saraca asoca Flower Extract on Prostate Cancer Cell Line

Role of lncRNAs as prognostic markers of hepatic cancer and potential therapeutic targeting by S-adenosylmethionine via inhibiting PI3K/Akt signaling pathways

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