Selenium nanoparticles have role in toxic waste removal and bioremediation. In a recent study, biosynthesis of many metal and metal oxide nanoparticles by different plant extracts was found to be stable even after wet heat sterilization process. In some studies, biosynthesis of silver, gold, and selenium nanoparticles using microorganisms and plant and parts. In this present study we have synthesized selenium nanoparticles using arrow root and analysed for its free radical scavenging activity. 20 mM of sodium selenite was prepared using 60 mL of distilled water and 40 mL of Arrowroot extract. It was kept in the shaker. Readings were taken for 3 days. Centrifugation was done at 8000 rpm. Pellet was collected and was used for antioxidants activity that is free radical scavenging activity. The antioxidant property of arrow root mediated selenium nanoparticles are comparatively higher than the standard antioxidant property. Calculations were done on the basis of reading that was obtained. This study proves that there is antioxidant activity that is free radical scavenging activity adopted by selenium nanoparticles extracted from arrow root.
Introduction: Chlorhexidine is considered to be gold standard drug in treating various oral infections. Metronidazole is effective for treating various anaerobic infections, including dental abscess and periodontal abscess. In current technical applications and material sciences, contact angle is a thermodynamic characteristic that describes the wettability of solid surfaces. The aim of this study is to compare the contact angle of chlorhexidine and metronidazole mouth gel. Materials and Methods: Total 10 samples of gel was used, involving 5 samples of 1% chlorhexidine gel and 5 samples of 2 % metronidazole gel. The contact angles were measured with the Ossila Goniometer after each sample was dispensed from a microsyringe on the facial surface of the microtomed tooth. The obtained values from the samples were determined, and the data was statistically analysed using SPSS software version 20.0. The paired t test was used to analyse the data. Results: From the data collected it was found that the average contact angle of the mouth gels that is chlorhexidine and metronidazole gel were 51.58 & 67.04 respectively. T test showed p value of 0.157, (p value < 0.05). Hence, it is statistically not significant. Chlorhexidine gel had a lower average mean of contact angle than metronidazole gel, which means chlorhexidine gel had got better wettability when compared to metronidazole gel. Conclusion: Thus, it can be concluded that chlorhexidine gel has a better tendency to wet the tooth or oral cavity surfaces when compared to metronidazole gel, thereby it can have better action in treating various oral conditions.
Peri-implant mucosistis is similar to gingivitis, the former affects the mucosa around implants without bone loss. The aim of this study was to determine the effectiveness of ozonated olive oil gel in the management of peri-implant mucositis. A randomized controlled clinical trial was conducted among 50 patients with peri-implant mucositis within the age group of 25-50 years. They were randomly divided into two groups with 25 participants in each group based on the intervention [Group A (Ozonated olive oil gel), Group B (Chlorhexidine gel)]. Silness and Loe plaque index (PI) and Loe and Silness gingival index (GI) were recorded at baseline and after 4 weeks. Paired <i>t</i>-test and independent <i>t</i>-test was used to test the significance. Within the groups, there was a statistically significant reduction in PI and GI from baseline (<i>P</i> < 0.05). However, the difference in PI and GI between both the groups was statistically insignificant (<i>P</i> > 0.05). Ozonated olive oil gel was equally effective to chlorhexidine gel in the management of peri-implant mucositis.
Background: Prostate cancer is the second most common cause of cancer deaths for men. The role of plants in the prevention and treatment of disease has been known from the dawn of civilization. Plants maintain the health and vitality of individuals and also cure diseases, including cancer without causing toxicity. More than 50% of all modern drugs in clinical use are of natural products, many of which have the ability to control cancer cells. Saraca Asoca (Roxb.), De. Wild or Saraca indica is one of the most ancient trees of India Aim: Aim of this study is to investigate the anti-cancer effects of Saraca Asoca flower extract on prostate cancer cell line. Materials and Methods: The anti-cancer effects of Saraca Asoca extract on prostate cancer cell lines was assessed by cell viability assay, cell and nuclear morphological studies. The multiple concentration of Saraca Asoca extract (0, 20, 40, 60, 80, 100 and 120 µg/ml) was used and IC50 doses were calculated. Results: The MTT (3-[4,5-dimethylthiazol-2yl]-2,5-diphenyl-tetrazolium bromide) assay results showed the percentage of cell viability significantly decreased in treated cells compared to control groups without any treatment was represented as 100% and we observed inhibitory concentration was 60µg/ml. Morphologic changes observed showed cell shrinkage, and cytoplasmic membrane blebbing, were observed under phase-contrast microscope. The apoptotic nuclei (intensely stained, fragmented nuclei, and condensed chromatin) were viewed under a fluorescent microscope. Conclusion: Overall, the present study results demonstrated the cytotoxic and proapoptotic effects of Saraca Asoca flower extract on prostate cancer cell line. However, more research is needed to understand the active prinsciple compounds present in the extract and molecular mechanisms of its anti-cancer effects.
The recent spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its association has gripped the entire community and has caused widespread public health concerns. There are various dental procedures that cause spread of the infection. There are risks due to lack of PPE, risks during dental procedure, risks involving handpiece, aerosols, droplets, during communication and contaminated surface. Minimum 30 articles were collected from Pubmed, Google Scholar. We acknowledge that due to lack of PPE, infection can spread more easily, oral surgery drills also cause aerosol and can be transmitted to the susceptible individuals. Communication between the patient and dentist has a high chance of infection transmission. Contamination from spatter and aerosol dissemination remains a significant hazard to dental personnel when high speed dental equipment is used. Dental practitioners have to be more careful while doing dental procedures as there is a high chance of risks for dentistry during covid-19 and proper guidelines should be there while doing dental procedures.
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