The effects of cyclooxygenase inhibitors on tumor-induced anorexia in rats

McCarthy, R.; Daun, M.

doi:10.1002/1097-0142(19930115)71:2<486::aid-cncr2820710233>3.0.co;2-a

Cited by 27 publications

(14 citation statements)

References 27 publications

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“…Walker 256 tumour has been considered to be a very well established model for the study of cachexia since the 1980s (Guaitani et al 1982). It induces most of the symptoms related to human cachexia and anorexia (McCarthy and Daun 1992), including alterations in the plasma concentration of most anabolic hormones (Seelaender et al 1996a) and marked changes in intermediary metabolism (Argilés and López-Soriano 1991;Seelaender et al 1996Seelaender et al , 1998.…”

Section: Animalsmentioning

confidence: 99%

Adipose tissue in Walker 256 tumour-induced cachexia: possible association between decreased leptin concentration and mononuclear cell infiltration

2004

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The adipose tissue (AT) is severely affected by cachexia, a paraneoplastic syndrome, which increases the morbidity and mortality of cancer. There is, however, a heterogeneous response to the condition, according to the AT depot. As plasma leptin concentration has been often reported to vary in cachexia, we have measured (species specific radioimmunoassay) the local concentration of leptin in three AT depots: retroperitoneal (RPAT), epididymal (EAT) and mesenteric (MES) of Walker 256 tumour-bearing rats. A reduced concentration of leptin ( P<0.0001) was found in all the depots and in the plasma of the cachectic rats, compared with controls already from day 4 after tumour cell injection. The presence of a cell infiltrate was observed in all AT obtained from the tumour-bearing animals. Ultrastructural analysis, along with immunocytochemistry for RT1B (indicating the presence of MHCII) and using antibody against mononuclear phagocytes, showed the cells to be macrophages. The profile of TNFalpha and PGE2 secretion by the infiltrate was investigated (commercial kits). There was increased production of both factors by the cells of all AT ( P<0.05) compared with peritoneal macrophages obtained from the cachectic rats, while the cells isolated from MES showed the highest synthesis of TNFalpha. The results suggest a possible modulation of the chronic locally produced TNFalpha and PGE2 upon leptin synthesis by the AT of the cachectic rats.

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Section: Animalsmentioning

confidence: 99%

Adipose tissue in Walker 256 tumour-induced cachexia: possible association between decreased leptin concentration and mononuclear cell infiltration

2004

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“…The non-tumor control group received 1 ml of saline instead. Tumor weight in grams was estimated by an empirically-derived formula: length× width×1.33/100 (McCarthy and Daun, 1993). Tumor masses were excised at sacrifice, weighed and then processed for H/E staining to validate the tumor development in each animal (data not shown).…”

Section: Aterials and M Ethodsmentioning

confidence: 99%

Serotonin transporter mRNA expression in the dorsal raphe nucleus of a tumor bearing mouse

Jahng

Choi²,

Joo³

et al. 2005

Exp Mol Med

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“…The Morris 7777 hepatoma was obtained from American Type Culture Collection (Line McA-RH7777; Bethesda, MD). A 1-mm tumor fragment was implanted between the scapulae with a trocar needle, as previously described (Fridriksdottir & McCarthy;McCarthy & Daun, 1993). The area between the scapulae was palpated daily for growth of the implanted tumor fragment.…”

Section: Animal Model Of Tumor Growthmentioning

confidence: 99%

Inhibitors of prostaglandin synthesis do not improve food intake or body weight of tumor-bearing rats

McCarthy

1999

Res. Nurs. Health

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Interleukin-1 (IL-1) and tumor necrosis factor (TNF) are immunoregulatory cytokines that mediate many aspects of the acute phase response to infection and injury. It has been hypothesized that these cytokines mediate the onset of the cachexia-anorexia syndrome with tumor growth. The anorexigenic effects of IL-1 are mediated in part by prostaglandins (PG). Therefore, the purpose of the present study was to determine if administration of ibuprofen (ibu) or indomethacin (indo), which inhibit PG synthesis, would affect the food intake and body weight of tumor-bearing rats. Rats were implanted with the Morris 7777 hepatoma, a tumor known to induce anorexia and weight loss in rats, and weight loss and leukocyte synthesis of IL-1 and TNF in mice. Treatment with indo or ibu did not improve food intake or body weight in the tumor-bearing rats. However, administration of ibu coincident with tumor implantation did result in smaller tumor mass compared to placebo-treated controls. The results of the present study suggest that PG synthesis is not a major factor in the onset of anorexia in this animal model of tumor-induced anorexia. However, further studies of the effects of inhibitors of PG synthesis on the kinetics of tumor growth are clearly indicated.

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The effects of cyclooxygenase inhibitors on tumor-induced anorexia in rats

Cited by 27 publications

References 27 publications

Adipose tissue in Walker 256 tumour-induced cachexia: possible association between decreased leptin concentration and mononuclear cell infiltration

Adipose tissue in Walker 256 tumour-induced cachexia: possible association between decreased leptin concentration and mononuclear cell infiltration

Serotonin transporter mRNA expression in the dorsal raphe nucleus of a tumor bearing mouse

Inhibitors of prostaglandin synthesis do not improve food intake or body weight of tumor-bearing rats

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