The Effects of Curcumae Longae Radix, Curcuma phaeocaulis Radix and Their Processed Products on Epo/EpoR Pathway and CD62p

Chen, Zhimin; Li, Wenbing; Quan, Liang; Zhou, Haiting; Zhao, Yuqing; Zhang, Xi; Hu, Lin; Hu, C.

doi:10.3389/fphar.2018.00736

Cited by 17 publications

(14 citation statements)

References 13 publications

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“…54 As a herb used for blood circulation promotion in TCM, several studies have provided evidence that Curcumae Radix could improve the hemorheological state in animal models. 55,56 Intragastric administration of Curcuma longa root decoction (0.9 g•kg -1 , 2 weeks) was found to significantly reduce the serum levels of Epo, EpoR, and CD62p, thus reducing the formation of physiological thrombosis in experimental rats. 55 Moreover, Chen et al reported that the same extract of Curcumae Radix could significantly improve the abnormality of 5-HT in plasma, β-EP in brain, and inhibit the expression of c-fos, which led to an analgesic effect in rats.…”

Section: Antioxidant Activitiesmentioning

confidence: 97%

“…55,56 Intragastric administration of Curcuma longa root decoction (0.9 g•kg -1 , 2 weeks) was found to significantly reduce the serum levels of Epo, EpoR, and CD62p, thus reducing the formation of physiological thrombosis in experimental rats. 55 Moreover, Chen et al reported that the same extract of Curcumae Radix could significantly improve the abnormality of 5-HT in plasma, β-EP in brain, and inhibit the expression of c-fos, which led to an analgesic effect in rats. 57 Besides the anti-inflammation effect described above, curcumolide derived from Curcuma wenyujin was also reported to have an anti-angiogenic effect in HUVECs and in a murine oxygen induced retinopathy model of ischemia-induced retinal neovascularization.…”

Section: Antioxidant Activitiesmentioning

confidence: 97%

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A Comprehensive Mini-Review of Curcumae Radix: Ethnopharmacology, Phytochemistry, and Pharmacology

Gao

Yang

et al. 2021

Natural Product Communications

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Curcumae Radix is an efficacious ingredient with various medicinal properties empirically used in traditional Chinese medicine (TCM) formula for the treatment of cancer, depression, chest pain, dysmenorrhea, epilepsy, and jaundice. However, either phytochemical or pharmacological information of Curcumae Radix underlying its traditionally medicinal uses is rarely summarized and systematically analyzed. To provide evidence for clinical trials, a comprehensive literature review has been prepared of the phytochemicals, and ethnopharmacological and pharmacological mechanisms of this herb. The review approach consisted of searching several web-based scientific databases, including PubMed, Web of Science, and Elsevier. The keywords included “Curcumae Radix,” “ Curcuma wenyujin,” “ Curcuma longa,” “ Curcuma kwangsiensis,” and “ Curcuma phaeocaulis.” Based on the proposed criteria, 57 articles were evaluated in detail. The accumulated data indicate that Curcumae Radix contains a number of bioactive phytochemicals, mainly sesquiterpenes, diarylheptanoids, and diarylpentanoids, which account for a variety of medicinal values, such as anticancer, anti-inflammation, anti-hepatic fibrosis, and antioxidant. A wide range of apoptotic proteins, cell adhesion molecules, inflammatory cytokines, and enzymic and nonenzymic antioxidants could be modulated by either Curcumae Radix or its bioactive compounds, thus underpinning a fundamental understanding for the pharmacological effects of this herb. This review highlights the therapeutic potential of Curcumae Radix to progress the development of versatile adjuvants or therapeutic agents in the future.

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Section: Antioxidant Activitiesmentioning

confidence: 97%

Section: Antioxidant Activitiesmentioning

confidence: 97%

A Comprehensive Mini-Review of Curcumae Radix: Ethnopharmacology, Phytochemistry, and Pharmacology

Gao

Yang

et al. 2021

Natural Product Communications

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“…As recorded in Chinese Pharmacopoeia (2020 edition), the root tuber of Curcuma longa L. (RCL) can promote blood circulation and relieve pain, promote qi and relieve depression, clear heart and cool blood, and treat hepatitis with jaundice [ 3 ]. Modern pharmacological research has shown that it has a variety of biological activities including improving the blood stasis model [ 4 , 5 ], alleviating pain [ 6 ], anti-tumor activities [ 7 ], et al The rhizome of Curcuma longa L. (RHCL) is known as Jianghuang in Chinese. Its actions include promoting qi, breaking blood, unblocking the meridian, and relieving pain [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of Volatile Constituents in Root Tuber and Rhizome of Curcuma longa L. Using Fingerprints and Chemometrics Approaches on Gas Chromatography–Mass Spectrometry

et al. 2022

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The root tuber and rhizome of Curcuma longa L., abbreviated, respectively, as RCL and RHCL, are used as different medicines in China. In this work, volatile oils were extracted from RCL and RHCL. Then, gas chromatography–mass spectrometry (GC–MS) was used for RCL and RHCL volatile oils analysis, and 45 compounds were identified. The dominant constituents both in volatile oils of RCL and RHCL were turmerone, (−)-zingiberene, and β-turmerone, which covered more than 60% of the total area. The chromatographic fingerprint similarities between RCL and RHCL were not less than 0.943, indicating that their main chemical compositions were similar. However, there were also some compounds that were varied in RCL and RHCL. Based on the peak area ratio of 45 compounds, the RCL and RHCL samples were separated into principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA). Then, 20 compounds with a variable importance for the projection (VIP) value of more than 1 were the high potential contributors for RCL and RHCL differences. Furthermore, ferric ion-reducing antioxidant power (FRAP) assay results demonstrated that the volatile oils of RCL and RHCL had antioxidant activities. This study provided the material basis for the research of volatile components in RCL and RHCL and contributed to their further pharmacological research and quality control.

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“…Among the metal oxide NCs, Bi 2 O 3 with a high atomic number has been reported to have the stopping power for high energy photons by being applied to the conversion layer [ 23 , 24 ]. Commonly used NCs are composed of hazardous substances with environmental problems, such as cadmium (Cd) and lead (Pb) [ 25 , 26 ]. Therefore, research on Cd- and Pb-free NCs has become more important, and use of In-based NCs, such as copper indium sulfide (CuInS 2 ) [ 27 ], indium phosphide (InP) [ 28 ], and indium zinc phosphide (InZnP) [ 29 ] tends to increase in photodetector, because they are quite similar to the Cd-based NCs in terms of optical properties and colloidal stability [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

A Study on an Organic Semiconductor-Based Indirect X-ray Detector with Cd-Free QDs for Sensitivity Improvement

Lee

Liu

Kang

2020

Sensors

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In this paper, we studied the optimized conditions for adding inorganic quantum dots (QD) to the P3HT:PC70BM organic active layer to increase the sensitivity of the indirect X-ray detector. Commonly used QDs are composed of hazardous substances with environmental problems, so indium phosphide (InP) QDs were selected as the electron acceptor in this experiment. Among the three different sizes of InP QDs (4, 8, and 12 nm in diameter), the detector with 4 nm InP QDs showed the highest sensitivity, of 2.01 mA/Gy·cm2. To further improve the sensitivity, the QDs were fixed to 4 nm in diameter and then the amount of QDs added to the organic active layer was changed from 0 to 5 mg. The highest sensitivity, of 2.26 mA/Gy·cm2, was obtained from the detector with a P3HT:PC70BM:InP QDs (1 mg) active layer. In addition, the highest mobility, of 1.69 × 10−5 cm2/V·s, was obtained from the same detector. Compared to the detector with the pristine P3HT:PC70BM active layer, the detector with a P3HT:PC70BM:InP QDs (1 mg) active layer had sensitivity that was 61.87% higher. The cut-off frequency of the P3HT:PC70BM detector was 21.54 kHz, and that of the P3HT:PC70BM:InP QDs (1 mg) detector was 26.33 kHz, which was improved by 22.24%.

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The Effects of Curcumae Longae Radix, Curcuma phaeocaulis Radix and Their Processed Products on Epo/EpoR Pathway and CD62p

Cited by 17 publications

References 13 publications

A Comprehensive Mini-Review of Curcumae Radix: Ethnopharmacology, Phytochemistry, and Pharmacology

A Comprehensive Mini-Review of Curcumae Radix: Ethnopharmacology, Phytochemistry, and Pharmacology

Comparative Analysis of Volatile Constituents in Root Tuber and Rhizome of Curcuma longa L. Using Fingerprints and Chemometrics Approaches on Gas Chromatography–Mass Spectrometry

A Study on an Organic Semiconductor-Based Indirect X-ray Detector with Cd-Free QDs for Sensitivity Improvement

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