The effects of continuous diazinon exposure on growth and reproduction in Japanese medaka using a modified Medaka Extended One Generation Reproduction Test (MEOGRT)

Flynn, Kevin; Lothenbach, Doug; Whiteman, Frank W.; Hammermeister, Dean E.; Swintek, Joe; Etterson, Matthew A.; Johnson, Rodney D.

doi:10.1016/j.ecoenv.2018.06.088

Cited by 11 publications

(9 citation statements)

References 28 publications

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“…The responses we observed in reaction to diazinon also confirm previous findings on zebrafish and medaka (Cao et al., 2018; Flynn et al., 2018). Diazinon is an organophosphate insecticide that inhibits acetylcholinesterase (Pope, 1999; PPDB, 2019) and is thus neurotoxic in target and many nontarget species (Pope, 1999).…”

Section: Discussionsupporting

confidence: 91%

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Testing for population differences in evolutionary responses to pesticide pollution in brown trout (Salmo trutta)

Nusbaumer

Cunha

Wedekind

2020

Evolutionary Applications

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Section: Discussionsupporting

confidence: 91%

“…Previous studies on S-metolachlor and diazinon (Cao et al, 2018;Flynn et al, 2018;Quintaneiro et al, 2017) were carried out at higher concentrations than we used here, and we even found significant toxicity at concentrations below the AA-EQS. This could be due to two reasons.…”

Section: Discussioncontrasting

confidence: 45%

Testing for population differences in evolutionary responses to pesticide pollution in brown trout (Salmo trutta)

Nusbaumer

Cunha

Wedekind

2020

Evolutionary Applications

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“…Diazinon solutions were prepared and monitored as previously described (Flynn et al, ). Premeasured diazinon stock solutions at a concentration of approximately 37 mg/L were diluted with LSW first to approximately 190 μg/L with a proportional dispensing pump (PDS100; Fluid Metering, Inc.).…”

Section: Methodsmentioning

confidence: 99%

“…Ten fish were randomly placed in replicate 1.8 L aquaria in one of the nine treatment groups in a combination of three diazinon concentrations (0, 10 and 20 μg/L) and three food rations (100%, 50% and 25%). Diazinon concentrations that would reduce growth but not cause mortality were chosen based upon previous long‐term exposures (Flynn et al, ). Ration choices were based upon our experience culturing Japanese medaka, but were largely arbitrary.…”

Section: Methodsmentioning

confidence: 99%

The effects of combinations of limited ration and diazinon exposure on acetylcholinesterase activity, growth and reproduction in Oryzias latipes, the Japanese medaka

Flynn

Johnson

Lothenbach

et al. 2020

J of Applied Toxicology

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Environmental contamination can negatively impact fish populations. In addition to acute toxicity leading to death, toxicants can reduce fish growth and lower reproduction. The potential for adverse population level effects of environmental contaminants are estimated to conduct risk assessments from laboratory toxicity tests that most often measure apical endpoints related to growth, survival and reproduction. The relationships between these effect endpoints are being evaluated to predict shifts in fish population demography better after exposure to environmental toxicants. Environmental contaminants can also affect fish populations indirectly by reducing prey biomass. However, estimating the magnitude of the combined effects of prey reduction and direct toxicity is difficult and rarely attempted. Here we describe a toxicity test designed to estimate the effect on Japanese medaka of both reduced food and chronic exposure to diazinon, an acetylcholinesterase inhibiting organophosphate pesticide. Fish were reared with limited food ration and/or diazinon exposure through a full life cycle to assess possible interactions between the two stressors in their effects on growth and reproduction. Diazinon exposure (10 or 20 μg/L), reduced ration (50% and 25% of ad libitum), or combinations of both lowered growth rates and reproductive output of Japanese medaka. In addition, growth and reproduction alone were modeled, and then various relationships between the two stressors (diazinon and ration) and how they relate to growth and reproduction were modeled.

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“…Characteristics shared by these species include reduced size, short life cycle and split spawning. In general, small-sized fish with short reproductive cycles, such as those most used in the studies described here, have been targeted in analyses and the development of specific protocols for toxicological tests that evaluate the potential of a chemical to negatively affect fish through endocrine dysregulation, mainly associated with reproduction but also secondarily by affecting growth, development, and survival (USEPA, 2009;Flynn et al, 2018). However, native species that are already being used in studies with biomarkers of aquatic contamination, such as tambaqui Colossoma macropomum (Cuvier, 1816) (Carvalho-Neta et al, 2015), do not appear in the studies analyzed here that focus on the effects of pesticide residues on reproductive processes.…”

Section: Histopathology (Gh) Gonadosomatic Index (Gsi) Sperm Quality and Embryonic Development (Ed)mentioning

confidence: 99%

Reproductive aspects of freshwater fishes exposed to pesticide-contamined environments: A systematic review

Santos¹,

Almeida²,

Costa³

et al. 2021

Rev. Bras. Gest. Amb. Sustent.

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Fish are the predominant group of vertebrates in aquatic environments, and they are directly affected by the presence of contaminants in water bodies, which undergo changes in the structure and function of communities and dynamics of the populations. The aim of the present study was to conduct a systematic review of studies that analyze the reproductive aspects of freshwater teleosts in environments contaminated by pesticides. A systematic search for scientific articles was carried out from 2000 to 2019 using the "Web of Science" database, using the descriptors "fish reproduction", "contamination", "toxicology", "ecotoxicity" and "biomonitoring", combined with the use of boolean operators "AND" and "OR". The content analysis was performed based on the titles and the summary, with a first screening. Then, 98 articles were read in full, with 40 being selected. 24 species of fish were recorded, with a predominance of Danio rerio (17.5%). Insecticides were present in 78% of the studies, mainly Endosulfan (35%) and Cypermethrin (13%). Reproductive endocrine disorders were the most reported pathways of action (57.5%). The effects of pesticides on the reproduction of freshwater teleosts are evident, requiring studies on structural changes in gonads and a decrease in the quality of gametes.

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The effects of continuous diazinon exposure on growth and reproduction in Japanese medaka using a modified Medaka Extended One Generation Reproduction Test (MEOGRT)

Cited by 11 publications

References 28 publications

Testing for population differences in evolutionary responses to pesticide pollution in brown trout (Salmo trutta)

Testing for population differences in evolutionary responses to pesticide pollution in brown trout (Salmo trutta)

The effects of combinations of limited ration and diazinon exposure on acetylcholinesterase activity, growth and reproduction in Oryzias latipes, the Japanese medaka

Reproductive aspects of freshwater fishes exposed to pesticide-contamined environments: A systematic review

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