The Effects of Complete and of Partial Removal of the Liver

Mann, Frank C.

doi:10.1097/00005792-192712000-00001

Cited by 91 publications

(29 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This phenomenon is accompanied by an accumulation of uric acid in the blood, with a consequent increased excretion of the substance if kidney function is maintained. The change from a normal urea metabolism does not appear in dogs deprived of as much as 70 per cent of the liver after an Eck fistula operation (9,21), although uric acid destruction may possibly fail to occur. Indications of a lack of urea formation or of cessation of uric acid destruction in dogs may be taken as definite evidence of liver insufficiency (9).…”

Section: The Insu~ciency In Rabbits Given Glucose After Ablation Of 9mentioning

confidence: 98%

“…The effect of glucose, especially by intravenous injection, in rabbits deprived of 90 per cent of the liver is as startling as in completely hepatectomized dogs (3,9). Prostrated, moribund animals will be found sitting up or moving about freely a few minutes after a single injection of 10 to 20 cc.…”

Section: The Insu~ciency In Rabbits Given Glucose After Ablation Of 9mentioning

confidence: 99%

“…Investigators are agreed (9,11,12) that the liver possesses a "factor of safety" so great that it is well-nigh impossible to remove enough parenchyma to produce insufficiency without fatally obstructing the portal flow. Workers partially ablating the liver in dogs and rats 745 on…”

mentioning

confidence: 99%

“…PARTIAL LIVER INSUFFICIENCY Ii~ RABBITS have found this difficulty insurmountable (9,11,13). In the rabbit our efforts have led to success.…”

mentioning

confidence: 99%

“…The animals unless treated succumb in 12 to 18 hours, with convulsions and low blood sugar. If given glucose they live for varying periods up to 3 days, eventually dying with symptoms like those exhibited by dogs deprived of the entire liver (2,9). For a study of the problems of liver insufficiency the method presents many advantages.…”

mentioning

confidence: 99%

See 4 more Smart Citations

The Production of Partial Liver Insufficiency in Rabbits

McMaster

Drury

1929

Journal of Experimental Medicine

View full text Add to dashboard Cite

Reasons enough for the existence of the liver are known. A host of functions have been ascribed to the organ already. Nevertheless the clinical condition of liver insufficiency is still a riddle. For the better understanding of it one must distinguish between functions which are essentially hepatic and those which can be carried out somewhere else in the body when the liver fails.The recent work on dogs by Mann (1-9) and his colleagues has greatly increased our knowledge of liver functions. But much remains to be learned, and the method of these authors is laborious. For this reason we venture to submit a simple procedure for inducing extreme liver insufficiency in rabbits.To approach the problem of liver insufficiency in animals three general types of procedure or their combination are available; total extirpation, partial ablation, and derangement of the organ by tying the bile duct or by chemical injury. The method of total extirpation, though it has serve~d most excellently (1-9), still leaves much to be desired. Death follows the operation so rapidly that scant time remains for study of its onset. The use of drugs to bring about liver derangement is questionable for one must assume that the substance employed acts only on the liver parenchyma and not elsewhere as well. The evidence for and against these methods has been reviewed by Marshall and Rowntree (10) and by Mann (9).The employment of partial ablation has also been open to objection. Investigators are agreed (9,11,12) that the liver possesses a "factor of safety" so great that it is well-nigh impossible to remove enough parenchyma to produce insufficiency without fatally obstructing the portal flow. Workers partially ablating the liver in dogs and rats 745 on

show abstract

Section: The Insu~ciency In Rabbits Given Glucose After Ablation Of 9mentioning

confidence: 98%

Section: The Insu~ciency In Rabbits Given Glucose After Ablation Of 9mentioning

confidence: 99%

mentioning

confidence: 99%

“…PARTIAL LIVER INSUFFICIENCY Ii~ RABBITS have found this difficulty insurmountable (9,11,13). In the rabbit our efforts have led to success.…”

mentioning

confidence: 99%

mentioning

confidence: 99%