The Amino-Acid Content of the Blood in Health and in Disease

Schmidt, E. G.

doi:10.1001/archinte.1929.00140030050005

Cited by 19 publications

(4 citation statements)

References 20 publications

(1 reference statement)

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“…Mosenthal (191 8) treated three patients with a high protein diet, and in each instance there was an improvement of the blood picture and a rough relationship between the degree of and the amount of protein assimilated. In thirty-two cases examined by Gettler and Lindeman (1920) the amino-nitrogen concentration of the blood was reported as raised, but this observation was not subsequently confirmed (Schmidt, 1929). The findings of other workers during this period were contradictory; for instance, Gibson and Howard (1923) found no marked change in nitrogen metabolism.…”

Section: Nitrogcrz Excretionmentioning

confidence: 87%

Amino‐Acid and Protein Metabolism in Pernicious Anaemia

Neill¹,

Weaver²

1958

Br J Haematol

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Section: Nitrogcrz Excretionmentioning

confidence: 87%

Amino‐Acid and Protein Metabolism in Pernicious Anaemia

Neill¹,

Weaver²

1958

Br J Haematol

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“…Urinary excretion of amino acids after intravenous administration in four of the patients with "active cirrhosis" varied little from the levels obtained in eight control subjects. Earlier studies demonstrated normal urine values in chronic hepatitis, cirrhosis, infectious and toxic jaundice (18,19). In the advanced stages of acute yellow atrophy a rise in the blood amino acid level and urinary excretion rates has been reported (18)(19)(20)(21).…”

Section: Resultsmentioning

confidence: 94%

“…Earlier studies demonstrated normal urine values in chronic hepatitis, cirrhosis, infectious and toxic jaundice (18,19). In the advanced stages of acute yellow atrophy a rise in the blood amino acid level and urinary excretion rates has been reported (18)(19)(20)(21). It was suggested that this was presumably due to lack of deamination.…”

Section: Resultsmentioning

confidence: 94%

Urinary Excretion of Amino Acids in Liver Disease 1

Dunn¹,

Akawaie²,

Yeh³

et al. 1950

J. Clin. Invest.

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Previous studies from the authors' laboratories have established the range of values for the urinary excretion of 15 amino acids by normal males and females (1, 2). A preliminary survey of the urinary excretion of tryptophane, histidine, and cystine in a variety of disease states, including liver disease, showed that almost one-half of the values were either higher or lower than those observed in the control series (3). Because of the abnormalities encountered in this study, and the known relationship of the liver to amino acid metabolism (4-6), further investigation has been made into the urinary excretion of amino acids in liver disease. The present report is a study of the urinary excretion of amino acids by 25 patients, the majority of whom had subacute or chronic cirrhosis. METHODSThe previously described methods (1-3, 7, 8) were employed for the preparation of the urine samples and the determination of amino acids by microbiological assay. The probable accuracy of the amino acid data is indicated by average deviations from the mean which averaged 5 (3.7-6.7) per cent for the values at the different levels of the samples. The serum albumin and globulin fractions and total protein were performed by the methods of Kingsley (9); the blood non-protein-nitrogen by the method of Peters and Van Slyke (10); the carbon dioxide combining power by the method of Van Slyke, Stillman, and Cullen (11); the blood sugar by the method of Benedict (12), and the prothrombin time by the Quick method (13). RESULTS

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“…When this information became of importance in connection with studies involving the concentration of certain nitrogenous constituents in blood and urine, the present investigation was undertaken. Folin's amino acid procedure has enjoyed a wide usage in biochemical fields (1,8,12). Certain divergent findings (4,10,15), however, which Danielson (3) contends result from the limited range in true proportionality due to the presence of a strong residual blank, have been reported.…”

mentioning

confidence: 99%