The Effects of Common Over-the-Counter Moisturizers on Skin Barrier Function: A Randomized, Observer-Blind, Within-Patient, Controlled Study

Leshem, Yael Anne; Wong, A.; McClanahan, Danielle; Simpson, Eric L.

doi:10.1097/der.0000000000000623

Cited by 8 publications

(11 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…48 After 4 weeks, there was no significant difference between TEWL measurements in the forearm receiving treatment versus the control forearm. 48…”

Section: Skincare and Skin Interventionsmentioning

confidence: 80%

“…Results showed no significant difference in TEWL values in tattooed sites compared with control sites 47 . Leshem et al 48 recruited twenty patients with atopic dermatitis older than 12 years old and randomly assigned them to apply one of four moisturizers: Cetaphil Cream, Aveeno Eczema Therapy Moisturizing Cream, CeraVe Moisturizing cream and Vaseline. Subjects applied the moisturizer to one of their forearms daily for 4 weeks and did not apply anything to the opposite forearm.…”

Section: Resultsmentioning

confidence: 99%

“…47 Results showed no significant difference in TEWL values in tattooed sites compared with control sites. 47 Leshem et al 48 recruited twenty patients with atopic dermatitis older than 12 years old and randomly assigned them to apply one of four moisturizers: Cetaphil Cream, Aveeno Eczema Therapy Moisturizing Cream, CeraVe…”

Section: Skincare and Skin Interventionsmentioning

confidence: 99%

See 2 more Smart Citations

“Normal” TEWL‐how can it be defined? A systematic review

Green

Feschuk

Kashetsky

et al. 2022

Experimental Dermatology

View full text Add to dashboard Cite

An optimal amount of water, especially in the stratum corneum, is essential for maintaining normal functioning, healthy skin. 1 Therefore, the amount of water from the skin is carefully regulated, in part through trans-epidermal water loss. 1 Trans-epidermal water loss (TEWL) is an objective measurement of the amount of water passively evaporating from a designated area of stratum corneum in a fixed amount of time due to the water vapour pressure gradient on either side of the skin. It has historically been used as a measure of barrier water function and skin integrity in healthy individuals. 2 Advantages of using a non-invasive marker of skin integrity such as TEWL include a lack of skin barrier destruction, and the potential for early detection of subclinical effects. 3 Elevated TEWL values may reflect barrier dysfunction in diseases such as atopic dermatitis and psoriasis. 4,5 Oppositely, decreased TEWL values reflect an intact or recovered dermal barrier. 5 Thus, TEWL values are typically measured for in vitro permeation testing (IVPT) to reflect a healthy skin sample, and regulatory agencies such as the Food and Drug Administration (FDA) and European Group for Efficacy

show abstract

“…48 After 4 weeks, there was no significant difference between TEWL measurements in the forearm receiving treatment versus the control forearm. 48…”

Section: Skincare and Skin Interventionsmentioning

confidence: 80%

Section: Resultsmentioning

confidence: 99%

Section: Skincare and Skin Interventionsmentioning

confidence: 99%

See 1 more Smart Citation

“Normal” TEWL‐how can it be defined? A systematic review

Green

Feschuk

Kashetsky

et al. 2022

Experimental Dermatology

View full text Add to dashboard Cite

show abstract

“…As far as we know, there are no more studies regarding the impact of emollients on epidermal barrier function in psoriatic patients. In atopic dermatitis (AD), TEWL improved in 20 AD patients after 4 weeks of treatment with four different moisturizers [ 31 ]. Nevertheless, Mohammed et al found increased TEWL values after applying emollients for 28 days [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, Mohammed et al found increased TEWL values after applying emollients for 28 days [ 32 ]. This inconsistent data on the effect of moisturizers on TEWL is possibly explained by the different composition of the moisturizers used in each study [ 31 ]. In agreement with this data, we observed a decrease in TEWL values after Vaseline jelly application, which may be explained by its immediate barrier-repairing effect in delipidized stratum corneum [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Study of Skin Barrier Function in Psoriasis: The Impact of Emollients

Maroto-Morales

Montero‐Vílchez

Arias‐Santiago

2021

Life

View full text Add to dashboard Cite

Psoriasis is a chronic multi-systemic inflammatory disease that affects the epidermal barrier. Emollients can be used as a coadjutant therapy for psoriasis management, but little is known about how the epidermal barrier function in psoriatic patients is modified by moisturizers. The objective of this study is to evaluate the effect of Vaseline jelly and a water-based formula on epidermal barrier function in psoriatic patients. Thirty-one patients with plaque-type psoriasis and thirty-one gender and age-matched healthy controls were enrolled in the study. Temperature, transepidermal water loss (TEWL), stratum corneum hydration (SCH), pH, elasticity and the erythema index were measured using non-invasive tools before and after applying Vaseline jelly and a water-based formula. TEWL was higher in psoriatic plaques than uninvolved psoriatic skin (13.23 vs. 8.54 g·m−2·h−1; p < 0.001). SCH was lower in psoriatic plaques than uninvolved psoriatic skin and healthy skin (13.44 vs. 30.55 vs. 30.90 arbitrary units (AU), p < 0.001). In psoriatic plaques, TEWL decreased by 5.59 g·m−2·h−1 (p = 0.001) after applying Vaseline Jelly, while it increased by 3.60 g·m−2·h−1 (p = 0.006) after applying the water-based formula. SCH increased by 9.44 AU after applying the water-based formula (p = 0.003). The use of emollients may improve epidermal barrier function in psoriatic patients. TEWL is decreased by using Vaseline, and SCH is increased by using the water-based formula.

show abstract