The effects of co-administration of probiotics and prebiotics on chronic inflammation, and depression symptoms in patients with coronary artery diseases: a randomized clinical trial

Moludi, Jalal; Khedmatgozar, Hamed; Nachvak, Seyed Mostafa; Abdollahzad, Hadi; Moradinazar, Mehdi; Tabaei, Ali Sadeghpour

doi:10.1080/1028415x.2021.1889451

Cited by 52 publications

(48 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The intake of Lactobacillus rhamnosus GG (LGG) also exhibited beneficial effects in reducing metabolic endotoxemia and mega inflammation in participants with CAD [ 73 ]. Another study conducted by the same group found that co-supplementation of probiotics and inulin in CAD subjects for eight weeks had beneficial effects on depression, anxiety, and inflammatory biomarkers [ 74 ]. On the other hand, the beneficial roles of probiotics on stroke have been researched, and four articles were found ( Table 1 ).…”

Section: Probiotics and Their Potential Role In Cvdmentioning

confidence: 99%

Potential Benefits of Probiotics and Prebiotics for Coronary Heart Disease and Stroke

Chiou

2021

Nutrients

View full text Add to dashboard Cite

Among cardiovascular diseases (CVDs), a major cause of morbidity and mortality worldwide, coronary heart disease and stroke are the most well-known and extensively studied. The onset and progression of CVD is associated with multiple risk factors, among which, gut microbiota has received much attention in the past two decades. Gut microbiota, the microbial community colonizing in the gut, plays a prominent role in human health. In particular, gut dysbiosis is directly related to many acute or chronic dysfunctions of the cardiovascular system (CVS) in the host. Earlier studies have demonstrated that the pathogenesis of CVD is strongly linked to intestinal microbiota imbalance and inflammatory responses. Probiotics and prebiotics conferring various health benefits on the host are emerging as promising therapeutic interventions for many diseases. These two types of food supplements have the potential to alleviate the risks of CVD through improving the levels of several cardiovascular markers, such as total and low-density lipoprotein (LDL) cholesterol, high sensitivity C-reactive protein (hs-CRP), and certain cytokines involved in the inflammatory response. In this review, we focus mainly on the preventive effects of probiotics and prebiotics on CVD via rebalancing the structural and functional changes in gut microbiota and maintaining immune homeostasis.

show abstract

Section: Probiotics and Their Potential Role In Cvdmentioning

confidence: 99%

Potential Benefits of Probiotics and Prebiotics for Coronary Heart Disease and Stroke

Chiou

2021

Nutrients

View full text Add to dashboard Cite

show abstract

“…A clinical study also proved the effectiveness and safety of Lactobacillus supplementation in preventing cardiac remodeling after MI ( 42 ). Supplementation of L. rhamnosus in patients with coronary artery disease had beneficial effects on depression, anxiety, and inflammatory biomarkers ( 44 , 45 ). In addition to the bacteria itself, the p75 protein isolated from L. rhamnosus GG ( 187 ) considerably reduced infarcts in rat cardiac tissues in a dose-dependent manner ( 188 ).…”

Section: Lactobacillus Strains Worthy Of Attention and Their Therapeutic Usementioning

confidence: 99%

Therapeutic and Improving Function of Lactobacilli in the Prevention and Treatment of Cardiovascular-Related Diseases: A Novel Perspective From Gut Microbiota

et al. 2021

View full text Add to dashboard Cite

The occurrence and development of cardiovascular-related diseases are associated with structural and functional changes in gut microbiota (GM). The accumulation of beneficial gut commensals contributes to the improvement of cardiovascular-related diseases. The cardiovascular-related diseases that can be relieved by Lactobacillus supplementation, including hypercholesterolemia, atherosclerosis, myocardial infarction, heart failure, type 2 diabetes mellitus, and obesity, have expanded. As probiotics, lactobacilli occupy a substantial part of the GM and play important functional roles through various GM-derived metabolites. Lactobacilli ultimately have a beneficial impact on lipid metabolism, inflammatory factors, and oxidative stress to relieve the symptoms of cardiovascular-related diseases. However, the axis and cellular process of gut commensal Lactobacillus in improving cardiovascular-related diseases have not been fully elucidated. Additionally, Lactobacillus strains produce diverse antimicrobial peptides, which help maintain intestinal homeostasis and ameliorate cardiovascular-related diseases. These strains are a field that needs to be further investigated immediately. Thus, this review demonstrated the mechanisms and summarized the evidence of the benefit of Lactobacillus strain supplementation from animal studies and human clinical trials. We also highlighted a broad range of lactobacilli candidates with therapeutic capability by mining their metabolites. Our study provides instruction in the development of lactobacilli as a functional food to improve cardiovascular-related diseases.

show abstract

“…Moreover, the effects of probiotics have yet to be tested in a clinical sample of treatment-naïve depressed patients. Additionally, some of the studies used a prebiotic concurrently with probiotics (symbiotic formulation); recently, it has been shown that adding inulin (a prebiotic) to probiotics improved psychological and inflammatory outcomes more effectively than two supplements separately [139]. Finally, the findings have indicated that probiotic supplementation is safe and well-tolerated.…”

Section: Key Features Of Rcts With Probioticsmentioning

confidence: 99%

Probiotics as a Treatment for “Metabolic Depression”? A Rationale for Future Studies

Gawlik-Kotelnicka

Strzelecki

2021

Pharmaceuticals

View full text Add to dashboard Cite

Depression and metabolic diseases often coexist, having several features in common, e.g., chronic low-grade inflammation and intestinal dysbiosis. Different microbiota interventions have been proposed to be used as a treatment for these disorders. In the paper, we review the efficacy of probiotics in depressive disorders, obesity, metabolic syndrome and its liver equivalent based on the published experimental studies, clinical trials and meta-analyses. Probiotics seem to be effective in reducing depressive symptoms when administered in addition to antidepressants. Additionally, probiotics intake may ameliorate some of the clinical components of metabolic diseases. However, standardized methodology regarding probiotics use in clinical trials has not been established yet. In this narrative review, we discuss current knowledge on the recently used methodology with its strengths and limitations and propose criteria that may be implemented to create a new study of the effectiveness of probiotics in depressive disorders comorbid with metabolic abnormalities. We put across our choice on type of study population, probiotics genus, strains, dosages and formulations, intervention period, as well as primary and secondary outcome measures.

show abstract

The effects of co-administration of probiotics and prebiotics on chronic inflammation, and depression symptoms in patients with coronary artery diseases: a randomized clinical trial

Cited by 52 publications

References 37 publications

Potential Benefits of Probiotics and Prebiotics for Coronary Heart Disease and Stroke

Potential Benefits of Probiotics and Prebiotics for Coronary Heart Disease and Stroke

Therapeutic and Improving Function of Lactobacilli in the Prevention and Treatment of Cardiovascular-Related Diseases: A Novel Perspective From Gut Microbiota

Probiotics as a Treatment for “Metabolic Depression”? A Rationale for Future Studies

Contact Info

Product

Resources

About